Microcapsule preparation rich in astaxanthin as well as preparation method and application of microcapsule preparation

An astaxanthin and microcapsule technology, applied in microcapsules, skin care preparations, medical preparations containing active ingredients, etc., can solve the problems of astaxanthin deterioration, low astaxanthin content, etc. The effect of increasing the content, increasing the content and high stability

Active Publication Date: 2021-10-22
HUAZHONG AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Aiming at the defects of the prior art, the present invention provides a microcapsule preparation rich in astaxanthin, its preparation method and application, which combines the molecular characteristics of astaxanthin and constructs a series of deep eutectic solvent systems for the The astaxanthin-rich microcapsule preparation prepared by emulsifying the astaxanthin-rich microcapsule preparation with the water phase containing a particle stabilizer under the action of an external force after being dissolved at the molecular level aims to solve the problem of astaxanthin microcapsule plasmids in the prior art. Technical problems such as low astaxanthin content, the need to use volatile toxic solvents in the preparation process, or the processing temperature being too high will cause astaxanthin to deteriorate.

Method used

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  • Microcapsule preparation rich in astaxanthin as well as preparation method and application of microcapsule preparation
  • Microcapsule preparation rich in astaxanthin as well as preparation method and application of microcapsule preparation
  • Microcapsule preparation rich in astaxanthin as well as preparation method and application of microcapsule preparation

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preparation example Construction

[0050] At present, the preparation of most deep eutectic solvents adopts the heating preparation method. The heating preparation method refers to mixing hydrogen bond acceptors and hydrogen bond donors in a specific molar ratio at room temperature or at a certain high temperature (50-100 ° C) until A homogeneous clear liquid was formed. Astaxanthin, as a fat-soluble functional component, has low solubility in commonly used organic solvents, but experiments have found that it has higher solubility in the deep eutectic solvent constructed by the present invention.

[0051] A kind of astaxanthin-rich microcapsule preparation proposed by the present invention comprises a wall material and a core material, wherein: the core material comprises astaxanthin and a deep eutectic solvent; and the astaxanthin is molecularly dissolved in In the deep eutectic solvent system; the wall material contains one or more of polysaccharide and protein. Wherein, the mass percent content of the astax...

Embodiment 1

[0092] At 80°C, mix thymol and lauric acid at a molar mass ratio of 2:1 and heat until clear and transparent, then cool and stand at room temperature to prepare a deep eutectic solvent.

[0093] Take 90 g of the above-mentioned deep eutectic solvent system, and heat and dissolve 10 g of astaxanthin in the deep eutectic solvent system at 90° C.

[0094] Take 30 g of the above-mentioned astaxanthin solution and disperse it in 70 g of water phase, wherein the components of the water phase are made of the following raw materials in parts by weight: 4 parts of soybean protein isolate, 2 parts of vitamin C, 1 part of ascorbic acid, and 1 part of gum arabic , 92 parts of deionized water. Blend the two phases of oil and water, and shear and disperse for 4 minutes at a shear speed of 16000 rpm in a high-speed shearing machine to prepare an oil-in-water Pickering emulsion.

[0095] The prepared emulsion is spray-dried to obtain astaxanthin microcapsule powder. The spray-drying conditi...

Embodiment 2

[0098] At 80°C, mix thymol and lauric acid at a molar mass ratio of 3:1 and heat until clear and transparent, then cool and stand at room temperature to prepare a deep eutectic solvent.

[0099] 93.8 g of the above-mentioned deep eutectic solvent system was taken, and 6.2 g of astaxanthin was heated and dissolved in the deep eutectic solvent system at 80° C.

[0100] Take 10 g of the above-mentioned astaxanthin solution and disperse it in 90 g of water phase, wherein the components of the water phase are made of the following raw materials in parts by mass: 1.5 parts of whey protein isolate, 0.75 parts of cellulose polysaccharide, and 0.75 parts of microcrystalline starch , 0.8 parts of ascorbic acid, 2 parts of carrageenan, and 94.2 parts of deionized water. Blend the two phases of oil and water, and shear and disperse for 4 minutes at a shear speed of 16000 rpm in a high-speed shearing machine to prepare an oil-in-water Pickering emulsion.

[0101] The prepared emulsion is ...

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Abstract

The invention belongs to the field of preparation of microcapsule preparations, and particularly relates to a microcapsule preparation rich in astaxanthin as well as a preparation method and application of the microcapsule preparation. The microcapsule comprises a capsule wall material and a core material which is wrapped by the capsule wall material and contains astaxanthin. The microcapsule preparation rich in astaxanthin is prepared by combining molecular characteristics of astaxanthin, constructing a series of deep eutectic solvent systems, dissolving astaxanthin at a molecular level to serve as an oil phase, and emulsifying the oil phase and a water phase containing a particle stabilizer under the action of external force. The astaxanthin exists in the microcapsule in a molecular state dissolving form, the embedding rate is high, the storage stability of the natural astaxanthin can be remarkably improved, the fluidity is good, and the in-vivo absorption rate of the natural astaxanthin can be remarkably improved. The microcapsule disclosed by the invention can be applied to products such as foods, beverages, cosmetics, skin care products, medicines and the like.

Description

technical field [0001] The invention belongs to the field of preparation of microcapsule preparations, and more specifically relates to a microcapsule preparation rich in astaxanthin, its preparation method and application. Background technique [0002] Astaxanthin is the strongest antioxidant currently known, and it can be used as a new type of active factor in food, beverages, cosmetics, skin care products, and medicines, and has huge market potential. Astaxanthin widely exists in animals and plants, but the untreated natural astaxanthin mainly exists in the form of oil-soluble astaxanthin, which has very poor water solubility, and acts as a strong antioxidant. It is easily oxidatively degraded and loses its activity when stored under normal conditions. The microcapsules can wrap the active substance in a protective layer formed by the wall material, which isolates the active substance from contact with the external environment and protects the wrapped active substance. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50
CPCA61K9/5052A61K9/5036A61K47/12A61K47/10A61K31/122A61P39/06A61K8/35A61K8/11A61K8/062A61K8/65A61K8/64A61K8/645A61K8/731A61K8/732A61K8/736A61K8/733A61K8/73A61K8/361A61K8/34A61K8/365A61K8/36A61Q19/00A61Q19/08A23L33/00A23L29/035A23L29/04A23L29/10A23L2/52A23P10/30A61K2800/52A23V2002/00A23V2200/30A23V2250/20A23V2250/1878A23V2250/5488A23V2250/708A23V2250/5028A23V2300/10A23V2200/222A23V2250/54252A23V2250/5108A23V2250/5118A23V2250/5036A23V2250/5432A23V2250/2132A23V2250/5026A23V2250/511A23V2250/5114A23V2250/042A23V2250/54246A23V2250/5422
Inventor 刘石林方溶熙李斌李艳李晶梁宏闪
Owner HUAZHONG AGRI UNIV
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