Preparation method of calcium glycinate complex

Abstract

The invention discloses a preparation method of a glycine calcium complex. The preparation method comprises the following steps: step S100, adding glycine and anhydrous calcium chloride into a solvent, stirring and mixing, heating to 60-100 DEG C, and carrying out complexation reaction to obtain a reaction solution, wherein the solvent is water or mother liquor, and the molar ratio of glycine to anhydrous calcium chloride being 2: (0.8-1.5); step S200, cooling and standing the reaction solution, adding the prepared calcium glycinate complex as a seed crystal, and carrying out a crystallization process to obtain a crystal mixed solution; step S300, performing centrifugal separation on the crystal mixed solution to obtain a crystal substance and liquid, wherein the crystal substance is a calcium glycinate tetrahydrate complex; and step S400, carrying out a drying process on the calcium glycinate complex tetrahydrate to obtain the calcium glycinate complex, wherein the drying process is divided into three sections and is carried out in a negative pressure environment or a vacuum environment. According to the invention, glycine and anhydrous calcium chloride are used as raw materials, and the process flow is improved and optimized, so that the product purity and yield can be improved, the production efficiency can be improved, and the resource and energy consumption can be reduced.

Description

Technical field [0001] The present invention relates to calcium supplement preparations, and in particular to a preparation method of calcium glycinate complex. Background technique [0002] The development of calcium supplement preparations has gone through three generations: inorganic salt calcium, traditional organic salt calcium and soluble organic calcium. The most commonly used first-generation inorganic calcium salt is solid calcium carbonate, which has high requirements on the quality and quantity of gastric acid secretion, and is more likely to cause stones in the body and gastrointestinal irritation symptoms. The second generation of traditional organic salt calcium, such as calcium lactate, calcium gluconate, calcium citrate, etc., has better solubility and less irritation to the gastrointestinal tract than inorganic calcium salts. The disadvantage is that the calcium content is relatively low. There are also certain side effects. The third generation of soluble...

AI Technical Summary

Problems solved by technology

The second generation of traditional organic salt calcium, such as calcium lactate, calcium gluconate, calcium citrate, etc., compared with inorganic calcium salt, has better solubility and less irritation to the gastrointestinal tract. The disadvantage is that the calcium content is relatively low. There are also certain side effects

This method has the following disadvantages: on the one hand, glycine first reacts with solid alkali in the first step, and then reacts in the second step with calcium chloride solution. Generally, 1 molar mass of glycine requires at least 1 molar mass of solid alkali to Complete the first step reaction, namely be equivalent to 100kg glycine need 53kg solid alkali consumption at least, thus it can be seen that the preparation method process step is comparatively complicated, and raw material cost is also higher; On the other hand, the sodium ion in the solid alkali is in the first In the first step reaction, it is combined with glycine to be glycine sodium salt. If the amount of solid base is high, in the second step reaction, glycine sodium salt and calcium chloride solution are mixed to generate glycine calcium complex. In the reaction solution, there will still be Part of the free-moving sodium ions and hydroxide ions usually use hydrochloric acid (HCl) for subsequent pH adjustments, which will cause sodium ions to react with chloride ions in hydrochloric acid to form sodium chloride, which will be cooled and crystallized later. The formation of sodium chloride crystals mixed in the calcium glycinate complex crystals, thus affecting the final product purity of calcium glycinate complex

But this method needs to obtain reaction product by ultrasonic radiation under organic solvent-absolute ethanol condition, and reaction product also needs through organic solvent (preferably absolute ethanol) repeatedly washing and then just can obtain calcium glycinate by centrifugation and vacuum drying process, Therefore, this method needs to use a large amount of ethanol, and there are also problems such as the recycling and utilization of ethanol and the hidden dangers it brings to the production process. Only the medium in the cleaning tank can be transferred to the reactants, the energy loss is large, and it is affected by various factors such as the amount of water in the cleaning tank, the position of the reaction bottle in the tank, etc., and the repeatability is poor

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