A kind of spraying dry powder gel dressing and preparation method thereof

A gel, dry powder technology, applied in bandages, surgery, surgical adhesives, etc., can solve the problems of low biosafety, poor transportability, difficult application, etc., to achieve high biocompatibility, easy storage, adhesion high intensity effect

Active Publication Date: 2022-06-03
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] This application provides a method for preparing a gel dressing by spraying dry powder, aiming at the difficult application problems of existing hydrogel dressings such as poor transportability and low biological safety

Method used

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  • A kind of spraying dry powder gel dressing and preparation method thereof
  • A kind of spraying dry powder gel dressing and preparation method thereof
  • A kind of spraying dry powder gel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method based on ion complex spraying dry powder gel dressing, the used preparation raw material is polyacrylic acid (PAA), and the concrete steps include:

[0032] 1) Preparation of PAA hydrogel: 2 g of acrylic acid, 0.5 mol% FeCl 3 , 2mg APS was dissolved in 8g deionized water, stirred evenly, the solution was degassed, transferred to a sealed glass bottle, placed in an oven at 20-40 °C, and after 24 hours, PAA hydrogel was obtained;

[0033] Follow the steps above to adjust FeCl 3 content, multiple PAA hydrogels were prepared: PAA 0.1 , PAA 0.25 , PAA 0.75 and PAA 1 .

[0034]2) Preparation of PAA dry powder: The PAA hydrogel was removed by dialysis to remove monomers and equilibrated to pH 5. Specifically, the gel was placed in a 3500 dialysis bag, and then dialyzed in a large amount of deionized water and PBS buffer. , until the pH is 5, the treated hydrogel block is broken into gel powder, transferred to a freeze dryer, and the dry gel powder is...

Embodiment 2

[0036] A hydrogen bond-based spraying dry powder gel dressing is based on a hydrogen bond preparation method, and the preparation raw materials are polyvinyl alcohol (PVA) and tannic acid (TA), and the specific steps include:

[0037] 1) Preparation of PVA-TA hydrogel: 20g of PVA was added to 80g of deionized water, heated and stirred at 90°C for 4 hours to prepare a 20wt% PVA aqueous solution, 20g of TA was added to 80g of deionized water, and fully dissolved to obtain 20wt% PVA solution. % TA aqueous solution, mix PVA solution and TA solution 1:1, stir manually for 3-5min, ionize the mixed solution at 3000r / min for 30min, collect the precipitate as PVA10-TA10 hydrogel;

[0038] According to the above steps, change the ratio, the other three PVA 20 -TA 20 , PVA 20 -TA 10 , PVA 10 -TA 5 Hydrogels are available;

[0039] 2) Preparation of PVA-TA dry powder: the PVA-TA hydrogel obtained in step 1) is frozen and ground into a hydrogel powder, and the PVA-TA dry powder is ob...

Embodiment 3

[0041] A preparation method for spraying dry powder gel dressing based on electrostatic interaction, the preparation raw material is poly-N,N,N-trimethyl-3-(2-methacrylamido)-1-propylammonium chloride (PMPTC ), sodium poly-p-styrene sulfonate (PNaSS), the concrete steps include:

[0042] 1) Preparation of polyelectrolyte double network hydrogel: Weigh 4 g of poly-N,N,N-trimethyl-3-(2-methacrylamido)-1-propylammonium chloride (MPTC) 50w% mono Body aqueous solution, 2g sodium p-styrene sulfonate (NaSS) were dissolved in 6g deionized water, 0.5mol% APS was introduced, after it was fully dissolved, degassed, placed in an oven at 60°C for 8h, the obtained PMPTC solution was dried and powdered , obtain PMPTC powder; Weigh 4g MPTC 50w% monomer aqueous solution, 2g NaSS dissolve in 6g deionized water, add 1mol% MBAA and 1g PMPTC, NaSS powder, after fully dissolved, introduce 0.5mol% APS, degas, put at 60 ℃ Oven for 8h to obtain PMPTC, NaSS double network gel;

[0043] 2) Preparation...

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Abstract

The invention discloses a gel dressing prepared by spraying dry powder, which is prepared from a hydrophilic polymer into a gel, which is lyophilized, pulverized, and dried into a powder, which reaches the surface of the tissue by spraying, and absorbs water through ion complexation, hydrogen bonding or electrostatic force In-situ powder-to-powder cross-linking and tissue bonding are achieved. The dressing of the present invention is a dry powder before application, which is easy to store, does not contain initiators and monomers, and has high biocompatibility. The dry powder can absorb moisture on the surface of wet tissues, eliminate the adhesion barrier, and achieve rapid wet tissue adhesion. The adhesive strength of the tissue is high, which can reach 10-50kpa; the essence of the dry powder is modular, and functional materials can be added according to the needs, and the dry powder can be applied to the wound surface by using a spraying device; the hydrogel dressing is activated by water to form a dense water The gel layer can achieve strong tissue adhesion. Under the trigger of water, the swollen particles self-assemble into a gel mass on the surface of the wound in situ, and realize the tight adhesion to large-area and irregular wound biological tissues.

Description

technical field [0001] The invention relates to the field of hydrogel adhesives, in particular to a preparation method of a gel dressing by spraying dry powder. Background technique [0002] Tissue adhesives have developed rapidly over the past few decades as an alternative to traditional surgical suturing. 1-5 Compared with the time-consuming operation of traditional surgical suture, some locations are inconvenient to operate, cause tissue damage and cause foreign body inflammatory reaction in the tissue, tissue adhesive has the advantages of convenient use, short operation time, and small tissue damage. One of the effective methods for these problems is applicable to minimally invasive surgery. 6 At present, compared with the extensive research and development of tissue adhesives, there are few products for clinical use, and their application scenarios are limited, which cannot fully meet clinical needs. The reasons mainly include: poor delivery ability of the gel materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61L24/06A61L24/00C08F220/60C08F212/14
CPCA61L26/0014A61L26/008A61L24/06A61L24/0031C08F220/60C08F212/30C08L33/02C08L29/04
Inventor 胡兵邓旭郭竣畅叶连松
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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