Preparation method and application of multifunctional antibacterial hydrogel dressing

A hydrogel, multifunctional technology, applied in application, pharmaceutical formulation, medical science, etc., can solve the problems of antibiotic drug abuse, poor mechanical properties of wound dressings, lack of adhesion performance, etc., and achieve durable antibacterial ability and significant antibacterial effect , promoting cell migration and hemostasis

Pending Publication Date: 2022-02-01
HEBEI UNIV OF TECH
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Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the above-mentioned prior art, and to provide a preparation method and application of a multifunctional antibacterial hydrogel dressing. Natural polysaccharides and flexible polyacrylamide networks form a double network, and the two-dimensional nanomaterial phenylboronic acid functionalized graphene is used as a nanofiller, which is prepared by polymerizing in prepolymerized dopamine; the antibacterial dressing solves the problem of poor mechanical properties of current wound dressings, The problem of lack of adhesion performance and abuse of antibiotics, and this invention is not limited by the precision of processing conditions, the preparation method is simple, the process conditions are mild, safe and reliable, biocompatibility and economical are better

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  • Preparation method and application of multifunctional antibacterial hydrogel dressing
  • Preparation method and application of multifunctional antibacterial hydrogel dressing
  • Preparation method and application of multifunctional antibacterial hydrogel dressing

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preparation example Construction

[0060] The preparation method of multifunctional antibacterial hydrogel dressing of the present invention, the method comprises the steps:

[0061] A The dihydroxy and oxadiazolyl modified quaternary ammonium salts (QAS) with excellent antibacterial properties are coupled to the natural antibacterial active polysaccharide carboxymethyl chitosan with better water solubility through isophorone diisocyanate (IPDI) sugar, to construct a novel quaternized carboxymethyl chitosan (QCS).

[0062] B Functionalization of two-dimensional photothermal material (GO) with 3-aminophenylboronic acid (PBA) and reduction reaction to prepare functionalized reduced graphene oxide (rGB) to increase cell affinity and prevent GO from occurring in hydrogel reunion phenomenon. In addition, phenylboronic acid can form boronate bonds with glycans on the bacterial surface for bacterial immobilization. rGB can be loaded onto the hydrogel through the diol bond on the PBA through subsequent chemical react...

Embodiment 1

[0067] The preparation of embodiment 1 quaternized carboxymethyl chitosan (QCS)

[0068] Take 0.275g (1.24mmol) of IPDI and 0.5g (1.24mmol) of QAS into a 25mL round bottom flask, add 10mL of DMF solution, and stir the mixture at 800-1000rpm / min at 25°C for 3h, and simultaneously Protected under a dry nitrogen atmosphere, and the progress of the reaction was detected by TLC. After the reaction was completed, precipitate with anhydrous ether at -4°C and repeat the operation three times. The precipitate was dried in vacuo to obtain 0.54 g (1.18 mmol) of the solid product QAS-IPDI.

[0069] The above product and CMCS (0.839g, the molar ratio of CMCM and QAS-IPDI is 1:0.3) were reacted in 20mL of DMF at 25°C for 24h with continuous stirring, the magnetic stirring speed was controlled at 800-1000rpm / min, and a dry nitrogen atmosphere was protected at the same time. . After the reaction was completed, the resulting mixed solution was placed in a dialysis bag with a molecular weigh...

Embodiment 4

[0073] Example 4 Preparation of phenylboronic acid functionalized reduced graphene oxide (rGB)

[0074]2 mL of graphene oxide (GO) (5 mg / mL) aqueous solution was placed in a 50 mL glass flask, and 18 mL of deionized water was added, followed by ultrasonic dispersion treatment for 30 min. Then, 30 mg of 3-aminophenylboronic acid (PBA) was added to the above solution, and the reaction was performed under vigorous magnetic stirring at 1200 rpm / min at 70° C. for 3 h in a water bath. Under these conditions, 3-aminophenylboronic acid-functionalized graphene oxide (GB) was prepared. After the reaction was completed, 20 mg of sodium ascorbate was added to the mixture obtained above, the temperature of the water bath was increased to 80° C. and the original stirring speed was kept stirring continuously, and the reaction was continued for 1 h. After the reaction was completed, it was naturally cooled to room temperature, and the resulting mixed solution was transferred to a centrifuge ...

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Abstract

The invention relates to a preparation method and application of a multifunctional antibacterial hydrogel dressing. The gel dressing is prepared by using antibacterial active quaternary ammonium salt functionalized rigid natural glycan and a flexible polyacrylamide network to form a double network, using two-dimensional nanomaterial phenylboronic acid functionalized graphene as a nanofiller, and polymerizing in prepolymerized dopamine. The obtained antibacterial dressing solves the problems that an existing wound dressing is poor in mechanical property, poor in adhesion property and abused in antibiotic drugs, the antibacterial dressing is not limited by the precision degree of processing conditions, the preparation method is simple, the process conditions are mild, and the antibacterial dressing is safe, reliable and better in biocompatibility and economical efficiency.

Description

Technical field: [0001] The invention belongs to the technical field of biomaterial preparation, and in particular relates to a preparation method of a multifunctional antibacterial hydrogel dressing that is stretchable, adherent, capable of promoting wound healing caused by drug-resistant bacteria infection, and has excellent biocompatibility. Background technique: [0002] As the first barrier of the human body, the skin plays an indispensable role in resisting external forces, immunity, sensory regulation, buffering physical or chemical stimuli, and preventing loss of nutrients and electrolytes. However, the skin is the most vulnerable, including burns, abrasions, lacerations, contusions, clinical surgical procedures, or other superficial injuries. In addition, bacterial infection caused by improper wound management is also a major threat to human health. Traditional clinical wound treatment methods such as gauze and bandages not only have problems such as incomplete wou...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L33/26C08L5/08C08L79/04C08K9/04C08K3/04A61L17/00A61L17/10A61L24/00A61L24/02A61L24/04A61L24/06A61L24/08A61L26/00A61L27/08A61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61L27/54A61L27/56
CPCC08J3/075A61L26/008A61L26/0066A61L26/0023A61L26/0014A61L26/0004A61L26/0019A61L26/0085A61L26/0061A61L24/0031A61L24/0015A61L24/08A61L24/06A61L24/02A61L24/046A61L24/0036A61L24/001A61L17/005A61L17/10A61L17/00A61L27/52A61L27/54A61L27/20A61L27/16A61L27/08A61L27/18A61L27/56A61L27/50A61L2300/404A61L2300/412A61L2300/236A61L2300/208A61L2300/602A61L2300/108A61L2400/04C08J2333/26C08J2405/08C08J2479/04C08K9/04C08K3/042C08L5/08C08L33/26C08L79/04Y02A50/30
Inventor 张计敏赵鹏邓梅桂陈小爱张宇瞿雄伟
Owner HEBEI UNIV OF TECH
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