Process for continuously producing anthranilic acid

A technology of anthranilic acid and phthalimide, which is applied in the field of continuous production of anthranilic acid, can solve problems such as low equipment utilization, low production efficiency, and back-mixing of raw materials, so as to improve production efficiency and reduce energy consumption. The effect of reducing consumption and reducing energy consumption

Pending Publication Date: 2022-02-08
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention mainly aims at the problems of low equipment utilization rate, low production efficiency, and back-mixing of raw materials in the above-mentioned intermittent production, and provides a continuous production of o-amino Process and device for benzoic acid

Method used

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  • Process for continuously producing anthranilic acid

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Experimental program
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Effect test

Embodiment 1

[0030] (1) Add 200kg of phthalimide, 600kg of pure water, and 527kg of 32% sodium hydroxide solution into phthalimide alkalization reaction kettle 1, start stirring, turn on and adjust the motor speed to make the material reach a turbulent state , the material gradually dissolves and the solution becomes clear;

[0031] (2), hydrogen peroxide storage tank / 1, concentrated hydrochloric acid storage tank 2, phthalimide alkalization reaction kettle 3, hydrochloric acid storage tank 4, open the corresponding bottom valve, through the interlocking control of the flow meter and the valve, respectively Enter the microchannel reactor 10 according to a certain flow rate, ensure that the reaction solution of the mixed solution of imine phthalimide basification solution, hydrogen peroxide and hydrochloric acid is 45s in the residence time of the microchannel, open the refrigerant valve of the reactor, control The temperature of the solution is 5°C, and the pH of the acidified solution pro...

Embodiment 2

[0036] (1) Add 200kg of phthalimide, 600kg of pure water, and 527kg of 32% sodium hydroxide solution into phthalimide alkalization reaction kettle 1, start stirring, turn on and adjust the motor speed to make the material reach a turbulent state , the material gradually dissolves and the solution becomes clear;

[0037] (2), 32% hydrogen peroxide storage tank 1, concentrated hydrochloric acid storage tank 2, phthalimide alkalization reaction kettle 1, hydrochloric acid storage tank 3, open the corresponding bottom valve, through the interlocking control of the flow meter and the valve, Enter microchannel reactor 10 respectively according to certain flow rate, guarantee that the reaction solution of imine phthalimide alkalization liquid, sodium hypochlorite solution is 60s in microchannel residence time, open the refrigerant valve of reactor, control the temperature of solution is 8°C, and the pH of the acidified solution produced is about 2.2, and enters the temporary storage ...

Embodiment 3

[0042] (1) Add 200kg of phthalimide, 600kg of pure water, and 538kg of 32% sodium hydroxide solution into phthalimide alkalization reaction kettle 1, start stirring, turn on and adjust the motor speed to make the material reach a turbulent state , the material gradually dissolves and the solution becomes clear;

[0043] (2) Hydrogen peroxide storage tank 1 concentrated hydrochloric acid storage tank 2, phthalimide alkalization reaction kettle 3, hydrochloric acid storage tank / 4 open the corresponding bottom valve, through the interlocking control of the flow meter and the valve, respectively according to a certain The flow rate enters the microchannel reactor 10 to ensure that the residence time of the reaction solution of the imine phthalimide alkalization solution and the sodium hypochlorite solution in the microchannel is 60s, and the refrigerant valve of the reactor is opened to control the temperature of the solution to be 8°C , the pH of the acidified solution produced i...

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Abstract

The invention discloses a process and a device for continuously producing anthranilic acid by taking phthalimide as a raw material. A process for continuously producing anthranilic acid by taking phthalimide as a raw material comprises the following steps of: (1) adding a phthalimide solid and pure water into a reaction kettle, stirring at a low speed, adding a 32% sodium hydroxide solution, and stirring at normal temperature for 30 minutes; (2) enabling a phthalimide sodium salt solution, a 32% hydrogen peroxide solution and a hydrochloric acid solution to respectively enter a micro-channel reactor according to a certain flow rate, be subjected to a Hofmann rearrangement degradation reaction at low temperature, and enter a temporary storage tank; and (3) pressurizing the slurry in the temporary storage tank through a slurry pump to enter a plate-and-frame filter press, treating the filtrate through a filtrate removal tower, then repeatedly applying the filtrate, and drying a filter cake to obtain isatoic anhydride with the purity of 99% or above.

Description

technical field [0001] The invention belongs to the technical field of chemical equipment, and in particular relates to a process for continuously producing anthranilic acid. [0002] technical background [0003] Anthranilic acid, also known as 2-aminobenzoic acid; carboxyaniline; 1-amino-2-carboxybenzene, is in the form of flaky crystals, yellow, and its melting point is 144-146°C. Anthranilic acid is an important intermediate widely used in the fields of pharmaceutical synthesis, fine chemical industry and organic synthesis. In the field of pesticides, anthranilic acid or its methyl ester can be used to synthesize the intermediate of bentazone. In the field of medicine, it is often used to synthesize mefenamic acid, milk-promoting vitamins, tranilast, etc.; in fine chemicals, it can be used to synthesize perfumes, anthraquinone dyes, azo dyes, such as disperse yellow 5G, etc. In addition, it can also be used as a complex reagent for the determination of cobalt, cadmium, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/22C07C229/56B01J19/00
CPCC07C227/22B01J19/0093C07C229/56
Inventor 岳涛郭鹏王达彤王艳卢福军周长海王瑞菲
Owner QINGDAO UNIV OF SCI & TECH
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