Dirithromycin enteric-coated tablet and preparation method thereof
A technology of dirithromycin and enteric-coated tablets, which is applied in the field of medicine, can solve the problems of poor product stability, unresolved, and decreased stability of dirithromycin, and achieve the effect of reducing the production of impurities
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0040] Embodiment 1: Preparation of Tablet Core 1
[0041] 1. Prescription
[0042] Get table 4 tablet core 1 prescription, be used to prepare 500 dirithromycin tablet cores whose specification is 0.125g and whose average tablet weight is 0.419g.
[0043] Table 4 Composition of Chip 1
[0044] composition mass (g) percentage(%) composition mass (g) percentage(%) Dirithromycin 62.50 29.8 Croscarmellose Sodium 2.92 1.4 microcrystalline cellulose 55.42 26.5 Sodium carboxymethyl starch 3.13 1.5 Heavy Magnesium Carbonate 59.17 28.2 Magnesium stearate 5.21 2.5 Hypromellose 20.21 9.6 colloidal silica 1.04 0.5
[0045] 2. Preparation method
[0046] Pass the raw material and auxiliary materials through a 40-mesh sieve, and set aside; take the prescribed amount of dirithromycin and colloidal silicon dioxide, mix them evenly for 5 minutes, and use them as premix 1 for later use; mix premix 1 with the prescribed amount...
Embodiment 2
[0047] Embodiment 2: preparation of tablet core 2
[0048] 1. Prescription
[0049] Get table 5 tablet core 2 prescription, be used to prepare 500 specifications and be 0.125g, the dirithromycin tablet core that average sheet weight is 0.385g.
[0050] Table 5 Composition of core 2
[0051] composition mass (g) percentage(%) composition mass (g) percentage(%) Dirithromycin 62.50 32.5 Sodium carboxymethyl starch 7.12 3.7 microcrystalline cellulose 48.65 25.3 polyethylene glycol 2.88 1.5 Heavy Magnesium Carbonate 33.46 17.4 Calcium stearate 1.54 0.8 pregelatinized starch 29.23 15.2 colloidal silica 4.62 2.4 Crospovidone 2.31 1.2 / / /
[0052] 2. Preparation process
[0053] Pass the raw material and auxiliary materials through a 50-mesh sieve, and set aside; take the prescribed amount of dirithromycin and colloidal silicon dioxide, mix them for 6 minutes, and use them as premix 1 for later use; mix ...
Embodiment 3
[0054] Embodiment 3: preparation of tablet core 3
[0055] 1. Prescription
[0056] Get table 6 tablet core 3 prescription, be used to prepare 500 dirithromycin tablet cores whose specifications are 0.125g and whose average tablet weight is 0.357g.
[0057] Table 6 Composition of core 3
[0058] composition mass (g) percentage(%) composition mass (g) percentage(%) Dirithromycin 62.50 35 Crospovidone 4.64 2.6 Heavy Magnesium Carbonate 44.29 24.8 Magnesium stearate 5.00 2.8 lactose 55.54 31.1 Talc powder (3000 mesh) 3.39 1.9 Croscarmellose Sodium 3.21 1.8 / / /
[0059] 2. Preparation process
[0060] Pass the raw material and auxiliary materials through a 60-mesh sieve, and set aside; take the prescribed amount of dirithromycin and talcum powder, mix for 10 minutes, and use it as premix 1 for later use; mix the premix 1 with the prescribed amount of heavy magnesium carbonate, lactose, Croscarmellose sodium an...
PUM
Property | Measurement | Unit |
---|---|---|
hardness | aaaaa | aaaaa |
particle size (mesh) | aaaaa | aaaaa |
hardness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com