Biomedical patch material based on polylipoic acid and preparation method thereof
A biomedical and octanoic acid technology, which is applied in medical science, adhesives, absorbent pads, etc., can solve the problems of difficult preparation process, complicated steps, double bond monomer and metal ion toxicity, etc., and achieve flexible adjustment of mechanical properties, easy to carry, The effect of fast and long-lasting adhesion
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Embodiment 1
[0068] (1) Preparation of hyperbranched poly-beta amino ester HPAE1:
[0069] Methylenebisacrylamide (MBA, 6.940g, 45mmol) and histamine dihydrochloride (HIS, 1.900g, 10mmol) were added to 30mL of dimethyl sulfoxide to fully dissolve in a round bottom flask, The molar ratio of double bond to amino active hydrogen is 3:1. Triethylamine was added to the mixture to adjust the pH to 8, and then the mixture was placed in an oil bath at 60°C for heating and reaction in the dark for 6h. After the reaction was completed, it was naturally cooled to room temperature. The reaction mixture was filtered to remove the salt precipitation produced during the reaction; then, the reaction mixture was thoroughly washed with 5 times the amount of methyl tert-butyl ether to remove the solvent and unreacted monomers, and the polymer was vacuumed Dry to remove excess purifying agent. The purified HPAE1 was stored in a refrigerator at -20°C.
[0070] (2) Preparation of polydopamine:
[0071] Pol...
Embodiment 2
[0075] (1) preparation of hyperbranched poly-beta amino ester HPAE2:
[0076] Polyethylene glycol diacrylate 700 (PEGDA700, 11.025 g, 15.75 mmol) and histamine dihydrochloride (HIS, 1.900 g, 10 mmol) were added to 30 mL of N,N-dimethylformamide to make it in It was fully dissolved in a round-bottomed flask, and the molar ratio of double bond to amino active hydrogen was 1.05:1. Triethylamine was added to the mixture to adjust the pH to 8, and then the mixture was placed in an oil bath at 60°C for heating and reaction in the dark for 6h. After the reaction was completed, it was naturally cooled to room temperature. The reaction mixture was filtered to remove the salt precipitation produced during the reaction; then, the reaction mixture was fully washed with 5 times the amount of ether to remove the solvent and unreacted monomers, and the polymer was vacuum-dried to remove excess purification agent. The purified HPAE2 was stored in a refrigerator at a temperature of -20°C. ...
experiment example 1
[0082] Experimental Example 1: Chemical structure characterization of polylipoic acid-polydopamine-hyperbranched poly-β aminoester-nanosilver medical patch material (PALA-PDA-HPAE-Ag):
[0083] The present invention summarizes the synthesis principles of each step in the embodiment, and the specific results are as follows Figure 1-3 .
[0084] figure 1 It is the synthesis schematic diagram of hyperbranched poly-beta amino ester HPAE1 in Example 1, which takes methylenebisacrylamide (MBA) and histamine dihydrochloride (HIS) as raw materials, and reacts under certain conditions to generate hyperbranched Poly-beta urethane HPAE1. Among them, dimethyl sulfoxide (DMSO) is the solvent, and triethylamine (TEA) is the catalyst.
[0085] figure 2 It is the synthesis schematic diagram of hyperbranched poly-beta amino ester HPAE2 in Example 2. It is based on polyethylene glycol diacrylate 700 (PEGDA700) and histamine dihydrochloride (HIS) as raw materials, and reacts under certain co...
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