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Magnetic nano-material for detecting tetrahydrocannabinoid and synthetic cannabinoid drugs as well as preparation method and application of magnetic nano-material

A magnetic nano and cannabinoid technology, applied in the direction of analysis of materials, material separation, chemical instruments and methods, etc., can solve the problems of limited materials, long time-consuming, high cost, etc., to achieve enhanced adsorption stability, good adsorption and separation effects, and reduce The effect of the preprocessing steps

Active Publication Date: 2022-08-02
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the liquid-liquid extraction method needs to use a large amount of organic solvents in the operation process, and the environmental friendliness is low; although the solid-phase extraction method has been widely used in the pretreatment of drugs, the technical operation of the method is relatively complicated, and the solid-phase extraction column is expensive , high cost, long time-consuming, unable to be popularized on a large scale; compared with traditional solid-phase extraction, solid-phase microextraction is more convenient and efficient to operate, but the materials for carrying the adsorption layer are limited and the fibers are fragile, and the adsorption capacity is low ;Compared with the traditional liquid-liquid extraction method, the liquid-liquid microextraction method does not require a large amount of organic solvents and has a high degree of environmental friendliness, but it is greatly affected by the matrix. It is suitable for the enrichment of low concentration analytes in clean samples The effect is better; while the magnetic solid phase extraction method has the advantages of simple operation, short extraction time, less use of organic solvents, and fast solid-liquid phase separation.

Method used

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  • Magnetic nano-material for detecting tetrahydrocannabinoid and synthetic cannabinoid drugs as well as preparation method and application of magnetic nano-material
  • Magnetic nano-material for detecting tetrahydrocannabinoid and synthetic cannabinoid drugs as well as preparation method and application of magnetic nano-material
  • Magnetic nano-material for detecting tetrahydrocannabinoid and synthetic cannabinoid drugs as well as preparation method and application of magnetic nano-material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Fe 3 O 4 Preparation of @PDA@poly(MAA-co-EGDMA) Magnetic Nanomaterials

[0039] Step 1, dissolve 1.46g of ferric chloride and 0.1g of sodium dodecyl sulfate in 100mL of deionized water, dissolve by ultrasonic, add 0.86g of ferrous chloride, stir to dissolve, use ammonia water to adjust the pH to 10, stir mechanically for 30min, The reaction product was separated and collected under the action of an external magnetic field, and then the product was ultrasonically cleaned three times with deionized water and absolute ethanol in turn to remove unreacted ferric chloride, etc., and finally the product was placed in a vacuum drying box at 60 ° C. under drying to obtain Fe 3 O 4 Nanoparticles;

[0040] Step 2, take by weighing 200mg Fe 3 O 4 Nanoparticles were evenly distributed in 250 mL of 10 mM Tris buffer at pH 8.5, 200 mg of dopamine hydrochloride was added, and mechanically stirred for 12 h. After the reaction was completed, the synthesized Fe was collected by magn...

Embodiment 2

[0047] Take Fe prepared in Example 1 3 O 4 Detection of drugs in sewage using @PDA@poly(MAA-co-EGDMA) magnetic nanomaterials.

[0048] Step 1, solution preparation

[0049] Preparation of test substance reference solution: respectively take 100 μg / mL 5F-EDMB-PINACA, FUB-APINACA, MDMB-4en-PINACA, MDMB-FUBINACA, PB-22 reference stock solution 100 μL, 10 μg / mL THC- 900 μL of COOH reference stock solution was placed in a 10 mL volumetric flask, and diluted to the mark with methanol.

[0050] Preparation of mixed internal standard solution:

[0051] Primary stock solution: Take 1 mL of the deuterated internal standard solution corresponding to 10 μg / mL THC-COOH in a 10 mL volumetric flask, dilute to the mark with methanol, and prepare a 1 μg / mL primary stock solution.

[0052] Working internal standard solution: Take 1 mL of the primary stock solution, put it in a 10 mL volumetric flask, and dilute to the mark with methanol to obtain a working internal standard solution contain...

Embodiment 3

[0086] Fe 3 O 4 The effect of the ratio of the dosage of @PDA and MAA on the adsorption of the target substance by magnetic solid phase extraction

[0087] examined different Fe 3 O 4 The effect of the dosage ratio of @PDA and MAA on the adsorption of the target by magnetic solid phase extraction, Fe 3 O 4 The effect of @PDA and MAA on the adsorption of the target (200ng / L) when the dosage ratio of PDA and MAA is 1:0.5 to 3. The specific operation for the synthesis of magnetic nanomaterials is the same as that in Example 1, the difference is that in step 3, Fe 3 O 4 The dosage ratio of @PDA and MAA is different, and with the different dosage of MAA, the amount of EGDMA and AIBN is adjusted according to the proportion of MAA. Then, the magnetic nanomaterials synthesized in different proportions are used for pretreatment and sample introduction detection according to the method of Example 2, and the results are as follows: Image 6 shown, with the Fe 3 O 4 With the incr...

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Abstract

The invention discloses a magnetic nano-material for detecting tetrahydrocannabinoid and synthetic cannabinoid drugs. The magnetic nano-material is Fe3O4 (at) PDA (at) poly (MAA-co-EGDMA). Wherein the Fe3O4 is located at the core, the outer layer of the Fe3O4 is wrapped with the polydopamine to form a core-shell layer, and the core-shell layer is wrapped with the polymethylacrylic acid crosslinked ethylene glycol dimethacrylate to serve as a loading layer. The prepared Fe3O4 (at) PDA (at) poly (MAA-co-EGDMA) magnetic nano material has the advantages that the complex matrix sample treatment process is simplified, the sensitivity of an instrument for detecting tetrahydrocannabinoic acid and synthetic cannabinoid drugs is greatly improved, the magnetic nano material can be matched with an on-site rapid detection instrument or a laboratory large-scale analysis instrument for use, pretreatment steps are reduced, the cost is reduced, and the detection efficiency is improved. The characteristics of complicated steps and low repeatability in the prior art are avoided, and high-flux automatic detection of trace drugs in sewage and urine is realized.

Description

technical field [0001] The invention relates to a magnetic solid-phase extraction material, in particular to a magnetic nanomaterial for detecting tetrahydrocannabinoid acid and synthesizing cannabinoid drugs, and a preparation method and application thereof. Background technique [0002] Sewage epidemiology, also known as sewage analysis method, can be used for quantitative and qualitative analysis and detection of human drug metabolites and drugs in urban sewage, combined with sewage flow and the number of people in the area covered by sewage treatment plants, to obtain regional drug abuse types, The drug situation data such as the number of abuse and the scale of abuse can objectively evaluate the drug abuse problem in a certain region, grasp the situation of drug situation in the region, and make prediction and early warning for the spread of drug situation in the future. At present, it has become one of the means to monitor the situation of drug abuse around the world. ...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/72
CPCB01J20/06B01J20/26B01J20/267B01J20/28026B01J20/28009G01N30/02G01N30/06G01N30/30G01N30/32G01N30/34G01N30/72Y02A50/30
Inventor 狄斌苏梦翔陈思敏张皓阅邓滨
Owner CHINA PHARM UNIV
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