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Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use

The technology of a diabetes drug and complex compound is applied in the field of capsules and bismaltol vanadium complex granules, a drug for treating diabetes, and can solve the problems of hypoglycemia, lactic acidosis, expensive drugs, etc. reduced effect

Inactive Publication Date: 2004-03-17
乐益
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among them, insulin sensitizers (such as pioglitazone and rosiglitazone) are newly marketed drugs abroad in the past two years, their clinical efficacy and safety need further investigation, and such drugs are expensive
[0007] α-Glucosidase inhibitors (such as acobolose, Baitangping, Miglitol, etc.) were used in the treatment of diabetes in the 1980s, and achieved certain curative effects, but for diabetic patients who need long-term medication, the price also expensive
[0008] Sulfonylurea drugs promote the secretion of endogenous insulin, inhibit the breakdown of glycogen, and promote the utilization of glucose by muscle, so they will cause hypoglycemia, especially for elderly patients, sometimes severe hypoglycemia and life-threatening
[0009] The hypoglycemic effect of biguanides is due to inhibiting the uptake of glucose by intestinal wall cells, promoting glycolysis and inhibiting hepatic gluconeogenesis. Biguanides will not cause hypoglycemia, but there is a possibility of lactic acidosis

Method used

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  • Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use
  • Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use
  • Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use

Examples

Experimental program
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Effect test

Embodiment 1

[0038] The application provides the preparation of the following granules and capsules as an example, but it is not limited to the scope mentioned in the application documents, and can be fully extended to slow-release, long-acting granules or capsules. The applicant believes that any Granules or capsules and their equivalents containing the main active ingredients pointed out in the present invention and used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) and related diseases shall all belong to the protection scope of this patent. Example 1 Preparation of compound granules or capsules of the present invention

[0039] The selected compound is 1,1-diethylbismaltol vanadium complex, in which vanadium is coordinated with oxygen; in addition to the main drug, non-starch excipients are used, specifically low-substituted hydroxypropyl cellulose (Lowsubstitued Hydroxypropyl Cellulose (LS-PHC) or Microcrystalline Cellulose (MCC), food flavors and non-carbohydra...

Embodiment 2

[0046] In addition to being used in the preparation of medicines for treating diabetes, it can also be used in the preparation of antihypertensive preparations, appetite suppressants for obesity, and preparations for regulating high cholesterol and high triglycerides. Example 2 Preparation of compound granules of the present invention

[0047] The main active ingredient is 1,1-diethyl bismaltol vanadium complex, and the vanadium in the complex coordinates with oxygen; the excipients are hydroxypropyl methylcellulose and microcrystalline cellulose; food flavor; sweet Flavor agent selects rebaudioside for use;

[0048] The specific weight ratio is: 100g of 1,1-diethyl bismaltol vanadium complex, 1g of hydroxypropyl methylcellulose, 45g of microcrystalline cellulose, 2g of stevioside, 1.5g of essence, and conventional amount of pigment . Use 30-40% ethanol as the wetting agent to make the soft material, and the soft material is made into granules through a granulator with 16-18...

Embodiment 3

[0048] The specific weight ratio is: 100g of 1,1-diethyl bismaltol vanadium complex, 1g of hydroxypropyl methylcellulose, 45g of microcrystalline cellulose, 2g of stevioside, 1.5g of essence, and conventional amount of pigment . Use 30-40% ethanol as the wetting agent to make the soft material, and the soft material is made into granules through a granulator with 16-18 meshes; it is dried at 35-40°C; the rest are the same as in Example 1. Example 3 Preparation of compound granules of the present invention by ebullating bed spraying

[0049] The main active ingredient is 1,1-diethylbismaltol vanadium complex, and the vanadium in the complex coordinates with oxygen; the binder is gelatin solution, and the auxiliary materials are methyl cellulose and microcrystalline cellulose; Edible flavors and sweeteners oligosaccharides or protein sugars;

[0050] The specific weight ratio is: 100g of 1,1-diethylbismaltol vanadium complex, 5g of methyl cellulose, 45g of microcrystalline cel...

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PUM

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Abstract

The present invention is double-maltol vanadium complex granule and capsule as diabetes treating medicine and their application. The medicine contains double-maltol vanadium complex as active component, and in the active complex double-maltol chelates vanadium to form five-element unsaturated vanadium-containing ring and vanadium is made to coordinate with oxygen, sulphur or nitrogen, preferablyoxygen. The medicine granule and capsule contains the active component as well as medicinal allowable supplementary material. The present invention is the development and extension of US patent No.5300496. The compound in the effective amount may be used in lower blood sugar and blood circulation as well as in inhibiting appetite for obesity and regulating cholesterol and triglyceride. The granule and the capsule with loose structure may be dissolved, diffused and absorbed to act.

Description

technical field [0001] The invention belongs to the field of medicine application, and in particular relates to a double maltol vanadium complex granule, a capsule and an application thereof. Background technique [0002] Diabetes mellitus (Diabetes mellitus) is a syndrome characterized by persistent high blood sugar as its basic biochemical feature. Various reasons lead to insufficient supply of insulin or the failure of insulin to play a normal physiological role in the target cells, which makes the metabolism of sugar, protein and fat in the body disordered, and diabetes occurs. With the prolongation of diabetes, if the metabolic disorder in the body is not well controlled, it can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels and heart, and eventually blindness, lower limb gangrene, Uremia, stroke or myocardial infarction, even life-threatening. [0003] Diabetes is a common disease. With the improvement of living stand...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/48A61K31/555A61P3/04A61P3/06A61P3/10A61P9/12
Inventor 乐益
Owner 乐益
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