Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use
The technology of a diabetes drug and complex compound is applied in the field of capsules and bismaltol vanadium complex granules, a drug for treating diabetes, and can solve the problems of hypoglycemia, lactic acidosis, expensive drugs, etc. reduced effect
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[0038] This application provides the preparation of the following granules and capsules as examples, but it is not limited to the scope mentioned in the application documents, and can be extended to sustained-release, long-acting granules or capsules. The applicant believes that all Granules or capsules and their equivalents that contain the main active ingredients indicated in the present invention and are used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) and related diseases shall fall within the protection scope of this patent. Example 1 Preparation of granules or capsules of the compound of the present invention
[0039] The selected compound is 1,1-diethylbismaltol vanadium complex, the vanadium in the complex is coordinated with oxygen; non-starch auxiliary materials are used in addition to the main drug, specifically low-substituted hydroxypropyl cellulose (Lowsubstitued Hydroxypropyl Cellulose for short LS-PHC) or Microcrystalline Cellulose for shor...
Example Embodiment
[0046] In addition to the application in the preparation of medicines for the treatment of diabetes, it can also be used in the preparation of antihypertensive preparations, obesity appetite suppressants, and high cholesterol and high triglyceride regulating preparations. Example 2 Preparation of compound granules of the present invention
[0047] The main active ingredient is 1,1-diethylbismaltol vanadium complex, the vanadium in the complex is coordinated with oxygen; the auxiliary materials are hydroxypropyl methylcellulose and microcrystalline cellulose; food flavor; sweet The flavoring agent is stevioside;
[0048] The specific weight ratio is: 1,1-diethylbismaltol vanadium complex 100g, hydroxypropyl methylcellulose 1g, microcrystalline cellulose 45g, stevioside 2g, flavor 1.5g, regular amount of pigment . Use 30-40% ethanol as a humectant to prepare a soft material. The soft material is granulated by a 16-18 mesh granulator; dried at 35-40°C; the rest is the same as in Exam...
Example Embodiment
[0048] The specific weight ratio is: 1,1-diethylbismaltol vanadium complex 100g, hydroxypropyl methylcellulose 1g, microcrystalline cellulose 45g, stevioside 2g, flavor 1.5g, regular amount of pigment . Use 30-40% ethanol as a humectant to prepare a soft material. The soft material is granulated by a 16-18 mesh granulator; dried at 35-40°C; the rest is the same as in Example 1. Example 3 Preparation of Compound Granules of the Invention by Fluidized Bed Spray
[0049] The main active ingredient is 1,1-diethylbismaltol vanadium complex, the vanadium in the complex is coordinated with oxygen; the binder is gelatin solution, and the auxiliary materials are methyl cellulose and microcrystalline cellulose; Edible flavors and sweeteners, oligosaccharides or proteoglycans;
[0050] The specific weight ratio is: 1,1-diethylbismaltol vanadium complex 100g, methylcellulose 5g, microcrystalline cellulose 45g, 6% gelatin solution 35g, oligosaccharide or protein sugar 2g, flavor 1.5g, the regu...
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