Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use

The technology of a diabetes drug and complex compound is applied in the field of capsules and bismaltol vanadium complex granules, a drug for treating diabetes, and can solve the problems of hypoglycemia, lactic acidosis, expensive drugs, etc. reduced effect

Inactive Publication Date: 2004-03-17
乐益
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among them, insulin sensitizers (such as pioglitazone and rosiglitazone) are newly marketed drugs abroad in the past two years, their clinical efficacy and safety need further investigation, and such drugs are expensive
[0007] α-Glucosidase inhibitors (such as acobolose, Baitangping, Miglitol, etc.) were used in the treatment of diabetes in the 1980s, and achieved certain curative effects, but for diabetic patients who need long-term medication, the price also expensive
[0008] Sulfonylurea drugs

Method used

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  • Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use
  • Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use
  • Granule, capsule formulation of dimaltol vanadium complex for Diabetes and its use

Examples

Experimental program
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Example Embodiment

[0038] This application provides the preparation of the following granules and capsules as examples, but it is not limited to the scope mentioned in the application documents, and can be extended to sustained-release, long-acting granules or capsules. The applicant believes that all Granules or capsules and their equivalents that contain the main active ingredients indicated in the present invention and are used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) and related diseases shall fall within the protection scope of this patent. Example 1 Preparation of granules or capsules of the compound of the present invention

[0039] The selected compound is 1,1-diethylbismaltol vanadium complex, the vanadium in the complex is coordinated with oxygen; non-starch auxiliary materials are used in addition to the main drug, specifically low-substituted hydroxypropyl cellulose (Lowsubstitued Hydroxypropyl Cellulose for short LS-PHC) or Microcrystalline Cellulose for shor...

Example Embodiment

[0046] In addition to the application in the preparation of medicines for the treatment of diabetes, it can also be used in the preparation of antihypertensive preparations, obesity appetite suppressants, and high cholesterol and high triglyceride regulating preparations. Example 2 Preparation of compound granules of the present invention

[0047] The main active ingredient is 1,1-diethylbismaltol vanadium complex, the vanadium in the complex is coordinated with oxygen; the auxiliary materials are hydroxypropyl methylcellulose and microcrystalline cellulose; food flavor; sweet The flavoring agent is stevioside;

[0048] The specific weight ratio is: 1,1-diethylbismaltol vanadium complex 100g, hydroxypropyl methylcellulose 1g, microcrystalline cellulose 45g, stevioside 2g, flavor 1.5g, regular amount of pigment . Use 30-40% ethanol as a humectant to prepare a soft material. The soft material is granulated by a 16-18 mesh granulator; dried at 35-40°C; the rest is the same as in Exam...

Example Embodiment

[0048] The specific weight ratio is: 1,1-diethylbismaltol vanadium complex 100g, hydroxypropyl methylcellulose 1g, microcrystalline cellulose 45g, stevioside 2g, flavor 1.5g, regular amount of pigment . Use 30-40% ethanol as a humectant to prepare a soft material. The soft material is granulated by a 16-18 mesh granulator; dried at 35-40°C; the rest is the same as in Example 1. Example 3 Preparation of Compound Granules of the Invention by Fluidized Bed Spray

[0049] The main active ingredient is 1,1-diethylbismaltol vanadium complex, the vanadium in the complex is coordinated with oxygen; the binder is gelatin solution, and the auxiliary materials are methyl cellulose and microcrystalline cellulose; Edible flavors and sweeteners, oligosaccharides or proteoglycans;

[0050] The specific weight ratio is: 1,1-diethylbismaltol vanadium complex 100g, methylcellulose 5g, microcrystalline cellulose 45g, 6% gelatin solution 35g, oligosaccharide or protein sugar 2g, flavor 1.5g, the regu...

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PUM

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Abstract

The present invention is double-maltol vanadium complex granule and capsule as diabetes treating medicine and their application. The medicine contains double-maltol vanadium complex as active component, and in the active complex double-maltol chelates vanadium to form five-element unsaturated vanadium-containing ring and vanadium is made to coordinate with oxygen, sulphur or nitrogen, preferablyoxygen. The medicine granule and capsule contains the active component as well as medicinal allowable supplementary material. The present invention is the development and extension of US patent No.5300496. The compound in the effective amount may be used in lower blood sugar and blood circulation as well as in inhibiting appetite for obesity and regulating cholesterol and triglyceride. The granule and the capsule with loose structure may be dissolved, diffused and absorbed to act.

Description

technical field [0001] The invention belongs to the field of medicine application, and in particular relates to a double maltol vanadium complex granule, a capsule and an application thereof. Background technique [0002] Diabetes mellitus (Diabetes mellitus) is a syndrome characterized by persistent high blood sugar as its basic biochemical feature. Various reasons lead to insufficient supply of insulin or the failure of insulin to play a normal physiological role in the target cells, which makes the metabolism of sugar, protein and fat in the body disordered, and diabetes occurs. With the prolongation of diabetes, if the metabolic disorder in the body is not well controlled, it can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels and heart, and eventually blindness, lower limb gangrene, Uremia, stroke or myocardial infarction, even life-threatening. [0003] Diabetes is a common disease. With the improvement of living stand...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/48A61K31/555A61P3/04A61P3/06A61P3/10A61P9/12
Inventor 乐益
Owner 乐益
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