Chinese medicine preparation for treating cardiac and cerebral vascular diseases and its preparing process

A technology for cardiovascular and cerebrovascular diseases and traditional Chinese medicine preparations, applied in cardiovascular system diseases, pharmaceutical formulations, medical preparations containing active ingredients, etc. To achieve the effect of high effective components of the extract, high bioavailability of the human body, and improved absorption and utilization

Inactive Publication Date: 2006-11-08
四川泰华堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) The sugar-coated tablet has a lot of dust in the preparation process, which is more harmful to the pharmaceutical production personnel; (2) The sugar-coated tablet has many processes in the production process, which lasts 72 to 96 hours, and the operating conditions are not easy to master, and the thickness of the isolation layer is easy to be uneven. Mottling, cracking, moisture absorption and other phenomena are prone to appear during the placement process, which affects the quality of the drug; (3) The disintegration time of sugar-coated tablets is 1 hour, and the dissolution time will increase with the prolongation of storage time; (4) Sugar-coated tablets The quality standard of the tablet is not perfect enough, and only the identification test is carried out on the finished product, so the production quality of the drug cannot be effectively guaranteed; (5) the amount of sucrose in the excipients of the sugar-coated tablet is relatively large, because many patients with cardiovascular and cerebrovascular diseases also have high blood sugar , the use of sugar-coating brings corresponding side effects to patients who avoid sugar, which is not conducive to the use of sugar-avoiding patients; (6) the disintegration time of the sugar-coated tablets is longer, which is not conducive to the rapid development of drug effects when treating emergencies such as coronary heart disease and angina pectoris. The bioavailability is low, and the curative effect of the drug cannot be fully exerted
[0005] In summary, the promotion of the above-mentioned tablet drug "Shuguan Tablet" is greatly restricted, and a new dosage form is urgently needed to replace the original sugar-coated tablet and improve the original quality inspection standard

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of capsule

[0033] 801 parts of Radix Polygoni Multiflori, 600 parts of Rhizoma Chuanxiong, 801 parts of Polygonatum

[0034] 600 parts of safflower, 600 parts of epimedium, 400.5 parts of Wulingzhi

[0035] Danshen 600 parts

[0036] (1) Weigh the raw materials according to the above dosage; (2) Remove the fibrous roots of the medicinal material Rhizoma Polygonatum, wash it, put it in boiling water for a while or steam it to the heart, and dry it at 60°C; the remaining six medicinal materials are cleaned and chopped, and set aside; (3) Put the above-mentioned Qiwei medicinal materials in an extraction container, add water to decoct and extract 3 times, the amount of water added each time is 12 times the amount of crude drug, each extraction is 2 hours, the extract is directly filtered, and concentrated to the relative Thick paste with a density of 1.10; (4) Add 95% ethanol to the thick paste to make the alcohol content reach 40%, let it...

Embodiment 2

[0037] Embodiment 2: the preparation of capsule

[0038] Polygonum multiflorum 801g Chuanxiong 600g Polygonatum 801g

[0039]Safflower 600g Epimedium 600g Wulingzhi 400.5g

[0040] Danshen 600g

[0041] (1) Weigh the raw materials according to the above dosage; (2) Remove the fibrous roots of the medicinal material Rhizoma Polygonatum, wash it, put it in boiling water for a while or steam it to the heart, dry it at 60°C, and chop the remaining six medicinal materials after cleaning, and set aside; (3) Put the above-mentioned Qiwei medicinal materials in an extraction container, add water to decoct and extract 3 times, the amount of water added each time is 10 times the amount of crude drug, the first extraction is 3 hours, the second and third extractions are 1 hour, and the extract is passed through large Adsorbed on a porous adsorption resin column, washed with 5 times the amount of water to remove impurities, and eluted sequentially with 4 times each of 50% ethanol and 70...

Embodiment 3

[0042] Embodiment 3: the preparation of soft capsule

[0043] 801 parts of Radix Polygoni Multiflori, 600 parts of Rhizoma Chuanxiong, 801 parts of Polygonatum

[0044] 600 parts of safflower, 600 parts of epimedium, 400.5 parts of Wulingzhi

[0045] Danshen 600 parts

[0046] Dispersion medium: 435 parts of olive oil

[0047] Suspending agent: Carbomer 25 parts

[0048] Emulsifier: 25 parts of liquid lecithin

[0049] Preservative: 1.5 parts of Ethyl Parkin Ethyl Ester

[0050] (1) Weigh the raw materials according to the above dosage; (2) Remove the fibrous roots of the medicinal material Rhizoma Polygonatum, wash it, put it in boiling water for a while or steam it to the heart, dry it at 60°C, and chop the remaining six medicinal materials after cleaning, and set aside; (3) Put the above-mentioned Qiwei medicinal materials in an extraction container, add water to decoct and extract 3 times, the amount of water added is 10 times the amount of crude drug, and each extrac...

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PUM

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Abstract

The present invention relates to a kind of Chinese medicine preparation for treating cardiac and cerebral vascular diseases and its preparation process. The Chinese medicine preparation has the features of easy disintegration, easy absorption, fast acting, high bioavailability and high curative effect. The main Chinese medicinal materials include fleeceflower root, Chuanxiong rhizome, etc , which are extracted to obtain dry extractum, and the dry extractum is crushed into powder and added with pharmaceutically acceptable carrier or excipient to prepare capsule, soft capsule, granule, oral disintegrant tablet or dispersed tablet. The Chinese medicine preparation is used mainly for treating coronary heart disease, angina, atherosclerosis, hyperlipemia and cardiac and cerebral vascular diseases.

Description

[technical field] [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, atherosclerosis, hyperlipidemia and antithrombotic and a preparation method thereof. [Background technique] [0002] Coronary heart disease, angina pectoris, atherosclerosis, hyperlipidemia, etc. are common vascular diseases. Coronary heart disease refers to the ischemic heart caused by coronary atherosclerosis caused by stenosis or blockage of the lumen. Due to acute occlusion of the coronary artery, some myocardium will suffer from angina pectoris due to severe and persistent ischemia. If it is not treated in time, local myocardial infarction will occur. Atherosclerosis is also a serious disease commonly seen in middle-aged and elderly people. It is a non-inflammatory, degenerative and proliferativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/16A61K9/20A61K9/48A61K35/24A61P9/10A61P9/12
Inventor 俞凯
Owner 四川泰华堂制药有限公司
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