Dendritic and star-shaped contrast agents for medical devices and bioabsorbable radiopaque bulk material and method for producing same
a bioabsorbable, bulk material technology, applied in the direction of prosthesis, surgery, organic active ingredients, etc., can solve the problems of inability to effectively hold open a diseased vessel, inability to effectively use a patient's vessel, and inability to achieve the necessary radial strength, so as to prevent the formation of a thrombosis, promote the binding and/or adhesion of embolic material, and increase the load of the filtering portion
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[0038] As shown in FIG. 1, when reacting pentaerythritol (100) with triiodobenzoic acid (200) in the presence of SOCl2 (the catalyst) and THF / Hexane (the reaction medium), the resulting contrast agent (300) may have a high iodine content of 85%, almost twice as high as commercially available agents (50) such as those under the tradename Ultravist®. In the reaction shown, triiodobenzoic acid (200) is the equivalent of a level 1 dendrimer, SOCl2 is the catalyst, and THF / Hexane is the reaction medium for the reaction (scheme 1). Accordingly, higher level dendrimers can be used. FIG. 2 shows the chemical structure of a level 4 dendritic polyamine (400), wherein the total number of amine group (401) is 2n. Each amine group (401) shown may be potentially conjugated to a triiodobenzoic moiety (200) for enhanced contrasting intensity. For example, for the level 4 dendritic polyamine (400) shown when the triiodobenzoic group (200) containing three iodine atoms is conjugated as shown in FIG. ...
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