36 results about "Brachymetatarsals" patented technology

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

This invention relates to the fields of brachytherapy and radiosensitization, specifically providing a... 125 I-nano implantable particles, their preparation methods, and applications. 125 The 1-nanometer implanted particles have a core-shell structure, consisting of a particle core and particles adsorbed on the outer surface of the particle core. 125 I and the particles encapsulated in the nucleus and 125 The outer shell of the I-type photosensitizer is a covalent organic framework. This invention... 125 The core of the I-nanometer implanted particle is used to enhance the energy deposition of gamma rays and X-rays, generating more hydroxyl radicals; the shell containing a type I photosensitizer is used to absorb the energy of Auger electrons and internal conversion electrons and excite the photosensitizer to generate singlet oxygen, effectively improving the response to... 125 The efficiency of I decay energy utilization. 125 I-nano implanted particles, combined with internal radiation therapy and radiodynamic therapy, destroy tumor cell DNA and cell membranes, enhance tumor killing and induce immunogenic cell death, thereby activating anti-tumor immunity and inducing remote effects.

1. Name of the product in this design: Dual-tube applicator. 2. Purpose of this design: A specialized device for delivering radiation sources to the target area in brachytherapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A system for mapping oxygen levels in tumors includes a needle that is sized to deliver high dose rate brachytherapy to tissue into which the needle is inserted, where the needle includes a radio frequency micro-coil sensor positioned within a shaft of the needle and a spin probe mounted to an outer surface of the shaft of the needle. A processor is in communication with the needle and configured to move the radio frequency micro-coil sensor along the shaft of the needle. The processor is also configured to receive, from the radio frequency micro-coil sensor, oxygen level readings at a plurality of tissue locations along the shaft of the needle. The processor is also configured to generate an oxygen level mapping of the tissue based on the oxygen level readings received from the radio frequency micro-coil sensor.

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

A rotating shield brachytherapy (RSBT) apparatus includes a radiation source, at least one applicator, a catheter, a catheter drive assembly, a robotic positioning system, and a connection system. The applicator(s) is configured to be inserted or implanted into a patient. A distal end portion of the catheter has at least one radiation shield and is configured to receive a wire-mounted radiation source. The catheter drive assembly causes helical motion of the catheter and engages the proximal end portion of the catheter to selectively rotate the catheter about a longitudinal axis. The robotic positioning system aligns the catheter drive assembly, in both position and angular orientation at a modifiable rate, with the applicator(s), or to any programmed point in space. The connection system couples the catheter drive assembly to the applicator(s), and further decouple the catheter drive from the applicator(s).

The application discloses a kind of afterloading brachytherapy precision positioning device, it is characterized in that, including: catheter;First source applicator includes first main part, first slot part, first insertion part, first air bag and multiple first elastic film;Second source applicator includes second main part, second slot part, second insertion part, second air bag and multiple second elastic film;Wherein, afterloading brachytherapy precision positioning device is configured as: in working condition, first opposite surface and second opposite surface hold fixed catheter, first insertion part inserts second slot part and extrudes second air bag, second elastic film is deformed and protrudes on second circumferential surface;Second insertion part inserts first slot part and extrudes first air bag, first elastic film is deformed and protrudes on first circumferential surface.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation and pulsating heat. Also described is a device for treating tumors at a target site. The device includes a first balloon containing a radio isotope and a second balloon encasing the first balloon. The second balloon defines structures to create a void between the first balloon and the second balloon such that pulsing, temperature treated fluid traverses the void.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation containing fluid and pulsating thermally treated fluid, wherein the fluids are separate from each other and confined to a balloon. Also disclosed is a device for treating a tumor excise site defined by a center and edges. The device includes a reversibly deformable container positioned at the center, the container encapsulating thermally treated fluid; a first drainage conduit; and a second radio-isotope containing conduit contacting a second longitudinally extending surface of the first drainage conduit so as to be positioned between the first drainage conduit and the center.

An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

A device with a central cylinder including multiple passageways and a plurality of channels spaced circumferentially around the central passageway. The device further includes a ring with a plurality of outlets and a plurality of frames coupled to the ring. Each of the plurality of frames includes a frame channel, a frame opening, and a distal end coupled to one of the plurality of outlets. A plurality of supports extend between the cylinder and the plurality of frames, and each of the plurality of supports is coupled to the cylinder with an adjustable lock. Each of the plurality of frames is adjustable with respect to the cylinder in response to movement of the corresponding adjustable lock with respect to the cylinder.

The application provides a vagina after-loading guide implant needle treatment device, a production equipment and a production process, and belongs to the technical field of brachytherapy equipment for cervical cancer. The vagina after-loading guide implant needle treatment device comprises a guide main body and a positioning damping sleeve. The guide main body comprises a guide head end, an intermediate cylinder, a tail end cylinder and an extension handle. The positioning damping sleeve is arranged at the front end of the guide head end. A plurality of groups of straight implant needle channels and a plurality of groups of inclined implant needle channels are arranged through the guide main body. The production equipment of the vagina after-loading guide implant needle treatment device comprises a first injection molding device for producing the guide head end and the tail end cylinder and a second injection molding device for producing the intermediate cylinder and the extension handle. Each component is separately injection molded, and the straight implant needle channels and the inclined implant needle channels are demolded. The vagina after-loading guide implant needle treatment device, the production equipment and the production process improve the production efficiency and reduce the production cost.

A device for surface brachytherapy includes a base configured for positioning a source with respect to a target area, an aperture defined in the base, and a shield body configured for coupling with the base, so that the source is secured within the base proximate or adjacent the aperture. The aperture is configured to transmit radiation emitted by the source, where the radiation is directed toward the target area. The base and shield body are configured to absorb at least a portion of the radiation emitted by the source, where the radiation is not directed toward the target area.

Various embodiments are described herein for a device and method for an integrated electromagnetic radiation treatment system comprising a sheath device and an electromagnetic radiation treatment delivery device for precise delivery of treatment to lesions on mucosal surfaces within body lumens. The system ensures accurate positioning of treatment applicators for brachytherapy and photodynamic therapy with simple visual confirmation, facilitating simple, low-tech, targeted treatment. The invention is particularly beneficial in settings where advanced imaging technologies are not available, offering a cost-effective and time-efficient solution for treatment planning and delivery.

The invention belongs to the technical field of radiopharmaceuticals and medical instruments, and discloses a preparation method and application of a palladium-103 brachytherapy source core. And the source core is composed of graphite particles which are subjected to surface modification treatment and are adsorbed with radionuclide palladium 103. The preparation method comprises the following steps: preparing graphite particles; acidizing and / or activating the graphite particles to introduce oxygen-containing functional groups on the surfaces of the particles and / or form porous structures to obtain surface modified graphite particles; and then mixing the particles with an alkaline solution containing palladium 103, and completing marking through oscillation adsorption. According to the method, the graphite particles are modified, a complex electroplating process is replaced, efficient and uniform adsorption of the palladium 103 is achieved, and the requirement for the purity of the graphite raw material is low. The method is simple in process, low in cost and easy for large-scale production, and the prepared source core is small in self-shielding effect and suitable for preparing brachytherapy devices such as a sealed seed source and an after-loading source.

The present invention provides a brachytherapy applicator device having: an elongate body defining a plurality of brachytherapy needle channels, each adapted and configured to receive a brachytherapy needle; a proximal end defining a plurality of proximal openings, each in communication with one of the plurality of brachytherapy needle channels; and a distal end defining a plurality of distal openings, each in communication with one of the plurality of brachytherapy needle channels, wherein at least some of the plurality of brachytherapy needle channels are curved away from a central axis of the elongate body at the distal end such that a brachytherapy needle inserted therethrough will engage with tissue lateral to a cross-sectional profile of the distal end of the elongate body.

The invention relates to the technical field of medical devices, in particular to an intelligent temperature control brachytherapy source applicator external member which comprises a source applicator and an external member body. The outer side of the advancing end of the source applicator is provided with an outer sleeve piece used for conducting deep regional thermal therapy on a patient, one side of the outer sleeve piece is provided with a heat insulation sleeve for achieving the heat insulation purpose, and the center of the heat insulation sleeve is provided with a mounting groove; wherein the interior of the mounting groove is matched with thermal therapy pieces with two thermal therapy modes, and the thermal therapy pieces are divided into a first thermal therapy piece and a second thermal therapy piece; temperature monitoring modules for temperature monitoring are mounted in the heat insulation sleeve at the upper and lower parts of the mounting groove; one end of the source applicator is provided with the external sleeve member, one side of the external sleeve member is provided with the thermal therapy member used for heating for treatment, when radiotherapy is carried out, the thermal therapy member with controllable temperature is started to carry out deep regional thermal therapy, and the radiotherapy and the thermal therapy are matched, so that the tumor treatment effect of a patient is better.

Presented herein are systems and methods for determining quality of brachytherapy treatment plans from catheter placement in organs in subjects. A computing system can identify a biomedical image of a section associated with an organ of a subject to be administered with brachytherapy in accordance with a treatment plan. The computing system can detect, from the biomedical image, (i) a plurality of positions corresponding to a plurality of catheters placed within the organ and (ii) a contour defining a structure of interest (SOI) in the biomedical image corresponding to a feature within the organ. The computing system can provide the plurality of positions and the contour as input to a machine learning (ML) model. The computing system can generate, based on providing the input to the ML model, a metric indicating a quality of the treatment plan for the plurality of catheters placed relative to the feature within the organ.

The present invention provides brachytherapy radiation delivery device designed to topically treat cutaneous skin lesions in patient tissue. The topical radiation delivery device includes a layer of one or more radionuclides. The topical radiation delivery device includes a high Z top shielding layer placed adjacent the side of the radionuclide layer away from the patient tissue. The top shielding layer attenuating the energy of the radionuclide from the environment external to the patient. The patch further includes a bolus layer placed between the patient tissue and the radionuclide layer which attenuates the beta radiation fluence. The one or more radionuclides of the brachytherapy radiation delivery device producing a gamma and beta radiation fluence to achieve a desired Percent Depth Dose within the cutaneous skin lesion.

The invention relates to a classification pre-judgment method and system for a brachytherapy source applicator uterine cavity tube. The prediction method comprises the following steps: A, preprocessing a medical image; b, constructing a deep learning classification prediction model; c, model training; d, outputting a result: inputting the independent test verification set into a pre-judgment system in sequence to obtain the probability of occurrence of each inclination angle; e, classification prediction result evaluation: based on a sklearn database, respectively calculating an ROC curve lower area value AUCi of each inclination angle classification for an independent test verification set and a model training set; aUCi of all independent test verification sets and model training sets is subjected to arithmetic averaging, and the result is used for evaluating the accuracy of system prediction through a final AUC result. Through artificial intelligence and medical imaging technologies, before the source applicator is implanted, the optimal bending angle of the uterine cavity tube is predicted and judged, the accuracy of the prediction system is quantitatively evaluated, a decision basis is provided for implementation of clinical after-loading treatment, the pain of a patient is relieved, and the treatment efficiency is improved.

The invention belongs to the technical field of brachytherapy medical instruments, and particularly relates to a source applicator and a preparation method thereof.The source applicator is prepared through the 3D printing technology, and the source applicator is prepared from, by mass, 13%-15% of Cu, 8%-10% of Zr, 8%-10% of Mo, 6%-9% of Nb, 2.5%-3.5% of Sn, 0.5%-1.5% of Si and the balance Ti. By adding Zr, Mo, Nb, Sn and other low-magnetic-susceptibility elements, the magnetic susceptibility of the titanium alloy is reduced to 1 / 3 of the magnetic susceptibility of pure titanium, the beta-phase titanium alloy is formed, then the omega-phase-containing titanium alloy source applicator is prepared and formed through the 3D printing technology and the hot isostatic pressing technology, the magnetic susceptibility is smaller, the MRI imaging artifact area is reduced, the source in-place precision is higher, and the application range is wider. And adverse effects on organs endangering are reduced.

The application provides a composite guiding system for brachytherapy, which comprises an image guiding module, a treatment plan confirming module, a guide plate registration module and an implant guide plate adjusting device, the image guiding module is connected with an image scanning device, a doctor terminal and the guide plate registration module respectively, the treatment plan confirming module is connected with the doctor terminal and the guide plate registration module respectively, one end of the implant guide plate adjusting device is connected with a treatment bed plate and an implant guide plate respectively, a position adjusting controller is arranged on the implant guide plate adjusting device, and the guide plate registration module is connected with the position adjusting controller. The composite guiding system for brachytherapy can guide the implant template to implant treatment after the implant guide plate position is finely adjusted to the target position in the brachytherapy plan, so that the implantation effect is better, and the pain caused by the resetting of the patient due to the inaccurate implant guide plate placement position in the treatment is avoided.

A brachytherapy composition fabricated from mammalian tissue is provided. Methods of processing a mammal's mammalian tissue to form a brachytherapy composition are provided. Regenerative methods are also provided.

A brachytherapy device including a primary guide, a telescoping primary applicator, a locator assembly for fixing the primary guide and the telescoping applicator, and a control system for managing the different components of the device is described. The primary applicator can be adjusted based on patient anatomy. The locator assembly includes a secondary applicator and a secondary guide connected to an expandable structure that can be inflated after insertion into the patient.

Disclosed herein are methods, pharmaceutical compositions, and kits for image-guided brachytherapy. An example method includes navigating a hollow tube to a tumor in a subject using an imaging modality and administering a pharmaceutical composition through the hollow tube to the tumor. An example pharmaceutical composition includes a pharmaceutically acceptable excipient and a collection of self-assembling conjugates, each self-assembling conjugate including a radionuclide coupled to an elastin-like polypeptide, the collection of self-assembling conjugates being included in the pharmaceutical composition at a concentration of no more than 300 µM.

The invention relates to a polymer coating for a brachytherapy device. The described embodiments include an apparatus (20, 21) comprising a support (22) comprising an outer surface (24) and configured for insertion into a body of a subject. The apparatus further includes a plurality of atoms (26) of a radionuclide that radionuclide decays radioactively to produce sub-radionuclides, the plurality of atoms of the radionuclide being coupled to the outer surface; and a layer (28, 33) of a polymer that is permeable to the child radionuclides, the layer of the polymer covering the atoms. Other embodiments are also described.

A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons by interaction with a proton beam (7), the neutron activator comprising: - a neutron source comprising a metal target (1), and - a beryllium first reflector-slower (4) located at the periphery of the neutron source and comprising a neutron activation zone (10) configured to house the neutron source and the material to be activated, the neutron activation zone (10) of the first reflector-slower (4) comprising an aperture configured to house the neutron source.

A brachytherapy seed applicator, comprising a hollow needle; a non-metallic elongated tube configured for insertion into tissue, within the hollow needle; a hub at a proximal end of the non-metallic elongated tube; one or more brachytherapy seeds carrying radioactive particles, within the non-metallic elongated tube; and a stylet configured to be inserted into the non-metallic elongated tube and to push the one or more brachytherapy seeds to a distal end of the non-metallic elongated tube, when the non-metallic elongated tube is in the tissue.

A dose calculation method for brachytherapy treatment, is disclosed, in which radiation is provided by one or more radiation sources from at least a first and a second dwell position within a patient. The method comprises performing a first dose calculation for the first dwell position according to a first dose calculation algorithm and a second dose calculation for the second dwell position according to a second dose calculation algorithm, and using the sum of the first dose calculation and the second dose calculations as the total calculated dose. Different dose engines with different properties can be combined to provide time-efficient calculations with satisfactory accuracy.