21 results about "Brachymetatarsals" patented technology

This invention relates to the fields of brachytherapy and radiosensitization, specifically providing a... 125 I-nano implantable particles, their preparation methods, and applications. 125 The 1-nanometer implanted particles have a core-shell structure, consisting of a particle core and particles adsorbed on the outer surface of the particle core. 125 I and the particles encapsulated in the nucleus and 125 The outer shell of the I-type photosensitizer is a covalent organic framework. This invention... 125 The core of the I-nanometer implanted particle is used to enhance the energy deposition of gamma rays and X-rays, generating more hydroxyl radicals; the shell containing a type I photosensitizer is used to absorb the energy of Auger electrons and internal conversion electrons and excite the photosensitizer to generate singlet oxygen, effectively improving the response to... 125 The efficiency of I decay energy utilization. 125 I-nano implanted particles, combined with internal radiation therapy and radiodynamic therapy, destroy tumor cell DNA and cell membranes, enhance tumor killing and induce immunogenic cell death, thereby activating anti-tumor immunity and inducing remote effects.

1. Name of the product in this design: Dual-tube applicator. 2. Purpose of this design: A specialized device for delivering radiation sources to the target area in brachytherapy. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A system for mapping oxygen levels in tumors includes a needle that is sized to deliver high dose rate brachytherapy to tissue into which the needle is inserted, where the needle includes a radio frequency micro-coil sensor positioned within a shaft of the needle and a spin probe mounted to an outer surface of the shaft of the needle. A processor is in communication with the needle and configured to move the radio frequency micro-coil sensor along the shaft of the needle. The processor is also configured to receive, from the radio frequency micro-coil sensor, oxygen level readings at a plurality of tissue locations along the shaft of the needle. The processor is also configured to generate an oxygen level mapping of the tissue based on the oxygen level readings received from the radio frequency micro-coil sensor.

A method for varying the radiation dosage in vivo during brachytherapy treatment is provided. The method includes infinitely varying the volume of radiation exposed to the patient. This volume variation feature is utilized as clinically indicated and can further reduce the risk of slippage of the device in situ.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation and pulsating heat. Also described is a device for treating tumors at a target site. The device includes a first balloon containing a radio isotope and a second balloon encasing the first balloon. The second balloon defines structures to create a void between the first balloon and the second balloon such that pulsing, temperature treated fluid traverses the void.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation containing fluid and pulsating thermally treated fluid, wherein the fluids are separate from each other and confined to a balloon. Also disclosed is a device for treating a tumor excise site defined by a center and edges. The device includes a reversibly deformable container positioned at the center, the container encapsulating thermally treated fluid; a first drainage conduit; and a second radio-isotope containing conduit contacting a second longitudinally extending surface of the first drainage conduit so as to be positioned between the first drainage conduit and the center.

An oxygen sensor is provided for measuring a dissolved oxygen concentration when deployed or implanted at a tissue site. The oxygen sensor includes a solid-state contrast agent for oxygen. The oxygen sensor is configured to indicate the dissolved oxygen concentration of a tissue when subjected to a magnetic resonance based method. The oxygen sensor may be used to map tumor oxygenation levels and for adaptive planning in brachytherapy.

A biocompatible seed for implantation in tissue of a patient includes an elongated body sized and shaped to be at least partially inserted into the tissue of the patient, in which the body includes a negative Poisson's ratio (NPR) material having a Poisson's ratio of between 0 and −1. The seed can be a thermal seed configured to generate heat responsive to exposure to a magnetic field. The seed can be a seed for brachytherapy that includes an inner layer including a radioactive material and an outer layer including the NPR material.

A device with a central cylinder including multiple passageways and a plurality of channels spaced circumferentially around the central passageway. The device further includes a ring with a plurality of outlets and a plurality of frames coupled to the ring. Each of the plurality of frames includes a frame channel, a frame opening, and a distal end coupled to one of the plurality of outlets. A plurality of supports extend between the cylinder and the plurality of frames, and each of the plurality of supports is coupled to the cylinder with an adjustable lock. Each of the plurality of frames is adjustable with respect to the cylinder in response to movement of the corresponding adjustable lock with respect to the cylinder.

A device for surface brachytherapy includes a base configured for positioning a source with respect to a target area, an aperture defined in the base, and a shield body configured for coupling with the base, so that the source is secured within the base proximate or adjacent the aperture. The aperture is configured to transmit radiation emitted by the source, where the radiation is directed toward the target area. The base and shield body are configured to absorb at least a portion of the radiation emitted by the source, where the radiation is not directed toward the target area.

The invention belongs to the technical field of radiopharmaceuticals and medical instruments, and discloses a preparation method and application of a palladium-103 brachytherapy source core. And the source core is composed of graphite particles which are subjected to surface modification treatment and are adsorbed with radionuclide palladium 103. The preparation method comprises the following steps: preparing graphite particles; acidizing and / or activating the graphite particles to introduce oxygen-containing functional groups on the surfaces of the particles and / or form porous structures to obtain surface modified graphite particles; and then mixing the particles with an alkaline solution containing palladium 103, and completing marking through oscillation adsorption. According to the method, the graphite particles are modified, a complex electroplating process is replaced, efficient and uniform adsorption of the palladium 103 is achieved, and the requirement for the purity of the graphite raw material is low. The method is simple in process, low in cost and easy for large-scale production, and the prepared source core is small in self-shielding effect and suitable for preparing brachytherapy devices such as a sealed seed source and an after-loading source.

The present invention provides a brachytherapy applicator device having: an elongate body defining a plurality of brachytherapy needle channels, each adapted and configured to receive a brachytherapy needle; a proximal end defining a plurality of proximal openings, each in communication with one of the plurality of brachytherapy needle channels; and a distal end defining a plurality of distal openings, each in communication with one of the plurality of brachytherapy needle channels, wherein at least some of the plurality of brachytherapy needle channels are curved away from a central axis of the elongate body at the distal end such that a brachytherapy needle inserted therethrough will engage with tissue lateral to a cross-sectional profile of the distal end of the elongate body.

Presented herein are systems and methods for determining quality of brachytherapy treatment plans from catheter placement in organs in subjects. A computing system can identify a biomedical image of a section associated with an organ of a subject to be administered with brachytherapy in accordance with a treatment plan. The computing system can detect, from the biomedical image, (i) a plurality of positions corresponding to a plurality of catheters placed within the organ and (ii) a contour defining a structure of interest (SOI) in the biomedical image corresponding to a feature within the organ. The computing system can provide the plurality of positions and the contour as input to a machine learning (ML) model. The computing system can generate, based on providing the input to the ML model, a metric indicating a quality of the treatment plan for the plurality of catheters placed relative to the feature within the organ.

The present invention provides brachytherapy radiation delivery device designed to topically treat cutaneous skin lesions in patient tissue. The topical radiation delivery device includes a layer of one or more radionuclides. The topical radiation delivery device includes a high Z top shielding layer placed adjacent the side of the radionuclide layer away from the patient tissue. The top shielding layer attenuating the energy of the radionuclide from the environment external to the patient. The patch further includes a bolus layer placed between the patient tissue and the radionuclide layer which attenuates the beta radiation fluence. The one or more radionuclides of the brachytherapy radiation delivery device producing a gamma and beta radiation fluence to achieve a desired Percent Depth Dose within the cutaneous skin lesion.

The invention relates to a classification pre-judgment method and system for a brachytherapy source applicator uterine cavity tube. The prediction method comprises the following steps: A, preprocessing a medical image; b, constructing a deep learning classification prediction model; c, model training; d, outputting a result: inputting the independent test verification set into a pre-judgment system in sequence to obtain the probability of occurrence of each inclination angle; e, classification prediction result evaluation: based on a sklearn database, respectively calculating an ROC curve lower area value AUCi of each inclination angle classification for an independent test verification set and a model training set; aUCi of all independent test verification sets and model training sets is subjected to arithmetic averaging, and the result is used for evaluating the accuracy of system prediction through a final AUC result. Through artificial intelligence and medical imaging technologies, before the source applicator is implanted, the optimal bending angle of the uterine cavity tube is predicted and judged, the accuracy of the prediction system is quantitatively evaluated, a decision basis is provided for implementation of clinical after-loading treatment, the pain of a patient is relieved, and the treatment efficiency is improved.

Disclosed herein are methods, pharmaceutical compositions, and kits for image-guided brachytherapy. An example method includes navigating a hollow tube to a tumor in a subject using an imaging modality and administering a pharmaceutical composition through the hollow tube to the tumor. An example pharmaceutical composition includes a pharmaceutically acceptable excipient and a collection of self-assembling conjugates, each self-assembling conjugate including a radionuclide coupled to an elastin-like polypeptide, the collection of self-assembling conjugates being included in the pharmaceutical composition at a concentration of no more than 300 µM.

A brachytherapy seed applicator, comprising a hollow needle; a non-metallic elongated tube configured for insertion into tissue, within the hollow needle; a hub at a proximal end of the non-metallic elongated tube; one or more brachytherapy seeds carrying radioactive particles, within the non-metallic elongated tube; and a stylet configured to be inserted into the non-metallic elongated tube and to push the one or more brachytherapy seeds to a distal end of the non-metallic elongated tube, when the non-metallic elongated tube is in the tissue.

Systems and methods for HDR brachytherapy planning can include obtaining patient specific data of a patient, and determining, using the patient specific data, an optimization problem to solve for a single-fraction HDR monotherapy plan including an objective function to be optimized subject to one or more first constraints on radiation doses within one or more OAR regions and a second constraint on radiation doses within the PTV. The systems and methods can include optimizing the objective function subject to the one or more first constraints and the second constraint, determining whether the first single-fraction HDR monotherapy plan satisfies the first and second constraints, updating a bound value of the second constraint based on whether the first single-fraction HDR monotherapy plan satisfies the first and second constraints, and optimizing the objective function subject to the one or more first constraints and the second constraint with the updated bound value.

Single-use brachytherapy systems for application of beta radiation to a target tissue, and methods of use. The single-use brachytherapy systems herein feature a cap into which a radionuclide brachytherapy source (RBS) can be inserted and a handle that removably attaches to the cap. When the handle is disengaged from the cap in order to access the RBS, the system is rendered useless for its original purpose, for its use as it was originally intended, for its use as prescribed, unless repaired.

The invention belongs to the technical field of medical instruments, and particularly relates to a brachytherapy equipment and CT equipment integrated device which comprises a ground structure, a moving assembly and a brachytherapy assembly, a clamping frame is fixedly connected to the rear portion of the upper end of the ground structure, and a partition plate is fixedly connected to the middle of the upper end of the ground structure; an electric push rod is fixedly connected to the upper end of the partition plate; a fixed plate is fixedly connected to the front part of the left end of the partition plate; the upper portion and the lower portion of the rear end of the fixing plate are fixedly connected with limiting rods, the outer surfaces of the two limiting rods are jointly sleeved with a baffle, the upper end of the ground structure is provided with a rail groove, the inner groove wall of the rail groove is fixedly connected with a rail, and the moving assembly is slidably connected with the rail groove and used for driving the brachytherapy assembly to move along the rail. Through driving of the two driving devices, the use position of the brachytherapy assembly can be adjusted, and a patient can complete the treatment process without getting out of a bed after CT is completed.

The disclosure relates to an improved brachytherapy device, methods of preparation, and uses thereof. More particularly, a flexible bioresorbable brachytherapy device is provided for application on a wound site in a subject. The device includes a sealed radioactive source having opposite first and second sides, wherein the sealed radioactive source includes a radioactive component comprising a plurality of radio-isotope particles dispersed within a carrier. A barrier surrounds the radioactive component providing the sealed radioactive source, wherein the barrier functions as a barrier, when implanted at the wound site, providing the sealed radioactive source for at least six half-lives of the plurality of radio-isotope particles. A bioresorbable shield located on the first side of the sealed radioactive source is configured to shield radioactivity when implanted at the wound site for at least six half-lives of the plurality of radio-isotope particles.