The invention discloses a content-centric networking multi-interest packet compression sending and processing method. The method comprises that compression interest packets are added, a content name part of each of the compression interest packets is divided into common prefixes of various interest content names and suffixes of the various interest content names, multiple interest packets which have a common prefix are compressed to be compression interest packet request data, when a network node receives the compression interest packets, the common interest prefix and the interest suffix are sliced to be an integrated content name, searching is carried out in content caching, a undetermined interest table and forwarding information table, forwarding interfaces are determined, for each interface, the common prefixes of the content names in all the interests to be sent are extracted, and the common prefixes and the surplus suffixes of the content names are combined to form a compressed interest packet which is sent.. The method effectively reduces the number of the interest packets in the network, and consumption of bandwidth is reduced, the compression problem of the multiple interest packets which have the same name prefix in the content center network is solved, and the content-centric networking multi-interest packet compression sending and processing method has stronger popularization and application value.