The invention relates to a surgery apparatus, in particular to a joint replacement surgery auxiliary positioning method and system based on inertia navigation. The system comprises a reference inertial sensor, a control terminal, a reference fixing frame, an adjustment inertial sensor, a distal femur osteotomy adjustment device, a distal femur osteotomy guider and a femur saw cutting groove. A method comprises the steps of S1, establishing communication connection among the reference inertial sensor, the adjustment inertial sensor and the control terminal; S2, demarcating the reference inertial sensor and the adjustment inertial sensor; S3, registering the femur; S4, calculating internal/external reversing angle and the front/rear inclining angle of the distal femur osteotomy adjustment device; S5, adjusting the internal/external reversing angle and the front/rear inclining angle through the distal femur osteotomy adjustment device, and determining the final osteotomy plane; and S6, performing osteotomy. According to the joint replacement surgery auxiliary position method and system disclosed by the invention, relevant axis recognition and positioning in the joint replacement surgery can be quickly realized, the surgery operation can be simplified, the surgery time is shortened, and the cost price can be reduced.