The embodiment of the invention discloses a joint replacement surgery navigation system and method. The system comprises a preoperative planning module, and a navigation registration module, wherein the preoperative planning module is used for performing segmentation and reconstruction according to obtained hip joint medical image data to obtain a hip joint three-dimensional model, performing preoperative planning, and determining the placement position, size and angle of a prosthesis; and the navigation registration module is used for determining the spatial positions of the pelvis and the femur according to a pelvis reference frame and a femur reference frame, registering the hip joint three-dimensional model according to the spatial position relationship between an operation probe and the pelvis reference frame and the femur reference frame to obtain a hip joint solid model, and according to the hip joint solid model, controlling a surgical instrument for clamping the prosthesis to place the prosthesis in the hip joint. Through preoperative planning of information such as an operation approach and a prosthesis placement position, a spatial positioning method is used during an operation to track the operation instrument, navigation support is provided for a doctor while the operation accuracy is improved, and the operation is safer and more efficient.