48 results about "Venous blood sample" patented technology

Disclosed herein is a fully-integrated, disposable biochip for point-of-care testing of clinically relevant parameters. Specifically, in accordance with an embodiment of the present invention, the biochip is designed for POCT (point-of-care-testing) of an array of metabolic parameters including partial pressure of oxygen, Glucose, and Lactate concentration from venous blood samples. The biochip is fabricated on a low-cost plastic substrate using mass manufacturing compatible fabrication processes. Furthermore, the biochip contains a fully-integrated metallic micro-needle for blood sampling. The biochip also uses smart passive microfluidics in conjunction with low-power functional on-chip pressure generators for microfluidic sequencing. The design, configuration, assembly and operation of the biochip are ideally suited for a disposable biochip specifically targeted towards POCT applications.

The invention relates to a device for determining two or more respiratory parameters relating to an individual and a method for determining two or more respiratory parameters relating to an individual by means of the device. The disclosed device and method may be used in an individual suffering from pulmonary gas exchange problems relating to gas exchange of oxygen and / or carbon dioxide, e.g. a patient with chronic obstructive pulmonary disease. The device and method may also be used in a healthy individual or in an animal, e.g. for research experiments. The device has detection means for oxygen and carbon dioxide contents in inspired and expired gas and blood. The device is controlled by a computer with functionality for entering oxygenation, carbon dioxide and acid-base values from one or more blood samples from arterial, venous, central venous or mixed venous blood samples, and with the parameter estimation based on equations of gas exchange of both oxygen and carbon dioxide and equations describing the acid-base chemistry of blood potentially including the competitive binding of oxygen and carbon dioxide to hemoglobin.

The invention relates to methods of converting venous blood values to arterial blood values. This has the advantage that arterial blood samples need not be taken, and the disadvantages compared to venous blood samples when taking arterial blood samples are eliminated. The method is basically based on three steps, namely the step of measuring arterial oxygenation, the step of measuring and estimating values of venous blood acid / base status and oxygenation status of a venous blood sample, and the step of converting the venous blood values by applying a mathematical model for deriving blood acid / base status and oxygenation status into estimated arterial blood values.

The invention discloses a vein blood sample shaking up device for a clinical laboratory of a hospital. The vein blood sample shaking up device comprises a base, a guide rod, a screw rod, a hoisting block, an arc-shaped clamping claw, a shaking up platform, a rectangular translation frame, a driving motor, an incomplete gear and a fixed sleeve ring, and is characterized in that the hoisting block is mounted on the screw rod through a thread; a clamping force arm is fixedly mounted at the right end of a shaft sleeve through a connecting rod; gears are arranged at front and rear sides in the rectangular translation frame; the gears in the rectangular translation frame are adaptive to a gear on the incomplete gear; the fixed sleeve ring is fixedly connected to the rear side of the rectangular translation frame trough a connecting rod. According to the vein blood sample shaking up device disclosed by the invention, a test tube is indirectly driven by manually rotating a shaking up wheel to move downward into the fixed sleeve ring, so that the shaking up of blood collection tubes with different lengths is met and the commonality of the shaking up device is improved; the incomplete gear is matched with the rectangular translation frame so that the fixed sleeve ring moves leftward and rightward and the blood collection tubes are driven to swing leftward and rightward, and furthermore, the shaking up effect of vein blood is improved.

The present invention is directed to holders for a sensor. The holders apply pressure to the sensor to prevent a venous blood signal without dampening the arterial blood signal and are optically opaque to shield ambient light from reaching the sensor.

The detection process of SARS virus of the gene detection reagent kit with rationing standard specific SARS virus nucleic acid as reference includes RNA extraction, PCR amplification and fluorescent detection. The venous blood sample, gargled liquid or respiratory tract secretion of the patient is used as the analysis sample directly, RNA of the sample is extracted as the nucleic acid template, and the template is used in fluorescent PCR amplification. The used fluorescent amplification detecting reagents includes one-step process RT-PCR buffering liquid, deoxynucleoside triphosphate (dNTP) mixture, specific amplification primer and specific probe. The method of the present invention is fast and convenient in detecting SARS virus.

Methods are provided for obtaining and testing or analyzing a non-venous and non-arterial puncture human fluid or cell sample or human body fluid or cell sample to detect the presence of at least one infectious disease. The sample may be menstrual fluid, endometrial menstrual cells, umbilical cord blood, or amniotic fluid. Confirmatory testing of a corresponding arterial or venous blood sample for comparison to the test results for the non-venous and non-arterial human fluid or cell sample may be performed. The testing may comprise a screening test or a confirmatory test.

A method and system for magnetic resonance imaging comprises applying at least one radiofrequency magnetization transfer (MT) pulse to a coronary venous region of a subject positioned within a magnetic field, and acquiring magnetic resonance imaging data from the coronary venous region to produce an image of a coronary venous structure. This technique can be utilized as part of a 3D free-breathing, ECG-triggered gradient-echo Cartesian acquisition of the coronary region. One or more magnetization transfer (MT) preparation pulses are used to enhance the contrast between venous blood and myocardium. The MT preparation results in myocardial signal suppression without any significant signal loss in the arterial or venous blood so as to maintain venous blood signal-to-noise ratio while improving contrast between myocardium and veins. The coronary venous structure can comprise one or more of a coronary sinus, a lateral vein and a posterior vein. The image of a coronary venous structure can be acquired in connection with an interventional cardiovascular procedure, such as a cardiac resynchronization therapy.

The invention relates to a separation and purification method for fetal nucleated red blood cells. The method is characterized by comprising the following steps: carrying out cracking treatment on nuclear-free red blood cells in a peripheral venous blood sample of a pregnant woman; adding a cell immobilization reagent in the blood sample subjected to cracking treatment; carrying out cell separation on the blood sample subjected to cell immobilization so as to obtain the fetal nucleated red blood cells. The invention further relates to a kit for separating and purifying the fetal nucleated red blood cells from the peripheral venous blood sample of the pregnant woman. According to the method and the kit, the yield and purity of separating of target cells are greatly improved, and a good foundation is laid for subsequent various analyses.

The invention discloses a limb local drug delivery and dialysis device and an application thereof. The limb local drug delivery and dialysis device is characterized in that an arterial blood inlet, an arterial blood outlet and at least one drug delivery inlet are arranged on an arterial chamber, wherein the arterial blood inlet is matched with one end of a main artery, and the arterial blood outlet is matched with the other end of the main artery. A venous blood inlet, a venous blood outlet, a dialysate inlet and a dialysate outlet are arranged on a venous chamber, wherein the venous blood inlet is matched with the limb side of the vein, and the venous blood outlet is matched with the proximal side of the vein. A blood coil of a dialysing tube structure is arranged in the venous chamber, one end of the blood coil is connected with the venous blood inlet, and the other end of the blood coil is connected with the venous blood outlet. The limb local drug delivery and dialysis device filter backflow venous blood molecules with specific sizes while performing arterial drug delivery, provides drugs for limbs on the affected side, and limits the drugs to the blood circulation in the affected limbs; discharges harmful substances generated by the affected limbs and prevents the harmful substances from entering whole-body blood circulation, thereby achieving the purpose of treating localized lesions of the limbs.

The invention involves a device and method for ascertaining the functioning of the respiratory system and, in particular, determining the cardiac output of a patient. The device comprises an apparatus containing sensors for measuring the oxygen and carbon dioxide concentrations as well as the volume of air inhaled and exhaled by a patient. The patient is provided a mouthpiece for breathing into and out of the device, which subsequently measures oxygen partial pressures of the inhaled and exhaled air. In addition, the patient's arterial oxygen saturation is continuously measured through pulse oximetry and the pH and hemoglobin concentration is determined from a venous blood sample. From this data, the cardiac output of the patient may be calculated.

The invention relates to an intelligent venous blood sampling positioning device based on computer vision. The blood sampling positioning device comprises a medical disinfection spraying module A, a computer vision module B, a core-x-y motion module C, a control module D, a supporting frame E, a computer and a bottom plate. A support frame E is fixed on one side of the bottom plate, and a computervision module B is fixed above the support frame E; a medical disinfection spraying module A and a core-x-y motion module C are respectively fixed on the other side of the bottom plate from left to right; the control module D is mounted on the bottom plate below the core-x-y motion module C; a blood sampling positioning part can freely move in the plane to reach a blood sampling point specified by a computer, and the venous blood sampling positioning task is efficiently and accurately completed.

The invention provides an anti-reverse-flow valve device for collecting venous blood samples and a blood collecting needle device, and relates to the technical field of medical instruments. The bloodcollecting needle device comprises a venous blood collecting needle, a tube plug puncture needle and a connecting part connected with the venous blood collecting needle and the tube plug puncture needle, and the connecting part is provided with the anti-reverse-flow valve device for collecting the venous blood samples; the anti-reverse-flow valve device comprises a first connecting base with a through hole in the middle, an elastic anti-reverse-flow valve installed on the first connecting base and a second connecting base cooperating with the first connecting base to form a cavity for containing the elastic anti-reverse-flow valve; the second connecting base is clamped to the first connecting base; the second connecting base is provided with a through hole communicated with the exterior, collected blood can be effectively prevented from reversely flowing into the human body, and the situation is avoided that blood contaminated by bacteria enters the human body and causes damage to thehuman body. In addition, the aseptic treatment on a whole blood collecting container can also be omitted, and the cost can be saved.

The invention belongs to the technical field of medical equipment, in particular relates to a portable electronic uniform-mixing instrument of venous blood sampling anticoagulation test tube blood samples, and mainly solves the problems of high hemolysis rates of blood samples, high work intensity of nurses and low efficiency existing in manual shaking of collected venous blood samples clinically. The portable electronic uniform-mixing instrument of the venous blood sampling anticoagulation test tube blood samples comprises a shell, and further comprises a power supply part, a motor, a delay adjustment potentiometer, a power switch and a test tube gripper, wherein the motor is arranged at the upper part of the shell, the test tube gripper is arranged outside the shell and connected with a rotating shaft of the motor, the power supply part is arranged at the lower part of the shell and connected with the motor and the delay adjustment potentiometer, the delay adjustment potentiometer is arranged in the shell and connected with the motor to adjust the rotating speed and the rotating time of the motor, a delay adjustment button is arranged on the shell and connected with the delay adjustment potentiometer, and the power switch is connected with the power supply part.

The invention provides a venous blood sampling hemostatic patch for people with low blood platelets. The venous blood sampling hemostatic patch includes a main body pad; hemostatic cotton is fixedly connected to the bottom of the main body pad; the interior of an air cavity is filled with hemostatic drug powder; an end cap is arranged in a nozzle; a sliding plate is inserted into the main body padand located on the outer side of the nozzle in a sliding mode, a sharp head and a through hole are formed in the sliding plate, a baffle penetrating through the sliding plate is movably inserted intoa right connecting base, a rubber band is arranged at the top of a left connecting base, and bandages are fixedly connected to the sides, opposite to each other, of the two connecting bases. When venous blood sampling hemostasis is carried out on the patient with low blood platelets, the main body pad is placed on a puncture point wound, a pressing pad is pressed, then a handle is hooked and lifted upwards, the sliding plate is pulled by a stretching device to move leftwards, the sharp head punctures the end cap, air pressure in the air cavity blows the hemostatic drug powder outwards, hemostasis is carried out on the wound, the blood coagulation time is shortened, and thus the workload of the patient and medical staff is reduced.

The invention relates to a blood pressure measuring method. The blood pressure measuring method comprises the steps of using a sample adding capillary fluid viscosity measuring device, an automatic control circuit based on a microprocessor and matching programs; injecting the processed to-be-measured blood sample into a sample pipe, and completely separating erythrocyte and plasma; starting the sample adding capillary fluid viscosity measuring device, and collecting first height position data in time when the bottom end of a sample adding probe contacts the liquid level of the plasma; starting an injection pump to extract the plasma at the constant speed, collecting pressure signals corresponding to the plasma viscosity in real time, and collecting second height position data in time when the bottom end of the sample adding probe contacts the liquid level of the erythrocyte; and calculating the blood pressure results of the venous blood sample by the microprocessor according to the first height position data and the second height position data.

The invention provides an intravenous infusion training system based on a VR platform. The system comprises a control host, a display device, a force feedback device and a foot-operated device. The control host is electrically connected with the display device, the force feedback device and the foot-operated device. The display device is used for displaying a venous blood sample acquisition model. The force feedback device is used for sending a first control signal to the control host according to operation of a user so as to carry out intravenous infusion simulation operation on a venous blood sample acquisition injection arm, and receiving feedback information of the control host to carry out force feedback on the user. The foot-operated device is used for sending a second control signal to the control host according to the operation of the user so as to carry out auxiliary operation on the intravenous infusion simulation operation. According to the invention, the intravenous infusion training system is achieved based on the virtual reality technology, so a problem of failure to carry out repeated trainings on invasive experiments in experiment teaching is solved; problems of poor simulation ability, incapability of resisting repeated puncturing, liquid leakage and mildewing of a current model are solved; and the provided system is an innovative and valuable supplement to current teaching modes.

The invention discloses a method for judging human body blood-qi acid-base disorder type. The method can obtain five indicators of arterial blood sample and venous blood sample simultaneously, namely HCO3(-), PaCO2, PH measured by arterial blood measure, Na(+), Cl(-) consistence measured by venous blood, and calculate anion gap AG of the sample. A technique scheme introduces deviation value percentage concept, processes relative parameter hereby and processes special prescribe to relative parameter, confirms relative formulation which can confirm original acid-bas disorder type in various acid-base disorder generating simply and limited, establishes the whole judge analysing process base and provides clear basis for clinic treating.

The invention discloses a genetic detection kit for communicating hydrocephalus. The kit comprises a RT-PCR buffer, a deoxy nucleoside triphosphate mixture, specific amplification primers and probes. The kit is convenient to sample, and venous blood samples of a to-be-detected patient can be sampled; the fluorescence amplification detection kit has the advantages of high sensitivity and strong specificity and can be used for early diagnosis; and the kit is of great significance for giving the early warning of patients with communicating hydrocephalus and taking effective treatment means.

The invention discloses a gene detection method for communicating hydrocephalus. According to the method, a venous blood sample of a to-be-tested patient is directly used as an analysis sample. The method comprises the following steps: (1) extracting RNA; (2) performing fluorescent PCR (polymerase chain reaction) amplification; (3) performing fluorescent amplification; and (4) performing result analysis. The detection method disclosed by the invention is simple to sample, is high in sensitivity and strong in specificity, can be used for early diagnosis, and is of great significance for carrying out early warning on communicating hydrocephalus patients and taking effective treatment means.

The invention discloses a detection kit for alpha-galactosidase activity, and belongs to the field of biochemical detection. The detection kit comprises a reaction solution, a precipitant, a stop solution, a linear standard substance and a reference substance, wherein the linear standard substance is a 4-methylumbelliferone solution, and the reaction solution is a 4-methylumbelliferone acyl-alpha-D-galactoside solution. The kit can rapidly and accurately carry out in-vitro detection on the activity of alpha-galactosidase in a human blood sample, and can achieve the purpose of rapidly, conveniently and accurately assisting in diagnosing Fabry disease patients in batches by detecting a collected filter paper dry blood slice sample or a venous blood sample; and the kit is high in detection sensitivity, good in selectivity, strong in anti-interference capability, good in reproducibility, simple and convenient to operate, good in product stability and easy to use clinically.

Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.

The invention discloses a child venous blood sampling auxiliary device, and the device comprises a mounting frame and a storage plate arranged on the upper end face of the mounting frame; a supporting rod is vertically arranged on the storage plate in a sliding mode, and a pressing plate used for abutting against the wrist of a child is arranged on the supporting rod; and a driving mechanism for driving the supporting rod to vertically move is arranged on the mounting frame. By arranging the pressing plate capable of pressing the wrist of the child on the storage plate, the wrist and the forearm of the child can be kept in a fixed state when a medical worker carries out blood sampling operation on the arm of the child, so that the shaking amount of the wrist or the forearm of the child is reduced, rapid blood sampling operation of the medical worker is facilitated, and the blood sampling device has the advantage that the blood sampling efficiency is improved.

The invention discloses a flexibly-adjustable infant venous blood sampling fixing frame which comprises a fixing supporting seat, a fixing belt is arranged at the top end of the fixing supporting seat, one end of the fixing belt is fixedly connected with the fixing supporting seat, and the other end of the fixing belt is fixedly connected with the fixing supporting seat. The other end of the fixing belt is connected with a movable adjusting mechanism located in the fixed supporting base in a matched mode, the movable adjusting mechanism is composed of a lead screw adjusting structure and a material collecting roller assembly, and the material collecting roller assembly is located at the top end of the lead screw adjusting structure and connected with the lead screw adjusting structure in a matched mode. The infant venous blood sampling fixing frame has the beneficial effects that the infant venous blood sampling fixing frame can be automatically adjusted, so that the fixing frame can be suitable for different infants, and the working efficiency can be effectively improved through automatic adjustment.

The invention provides a disposable collection needle capable of synchronously collecting multiple tubes of venous blood samples, comprising a connecting seat, the bottom of the connecting seat is provided with a diversion hole communicating with the puncture needle, and the inside of the connecting seat is rotatably connected with a sealing plate, the sealing plate The outer side of the adjustment plate is connected with a swivel ring, the front of the adjustment plate is provided with tooth segments corresponding to the teeth, the inside of the fixed pipe is movably inserted with a positioning rod inserted into the inside of the adjustment plate, and the outer side of the positioning rod is fixedly connected with a floating plate. The suction component pumps air from the connecting seat and the puncture needle, and the floating plate drives the positioning rods to move up under the action of the suction force. After all the positioning rods leave the positioning grooves, the adjustment plate will move under the action of the spring and pass through the teeth. The segments and teeth drive the swivel to rotate, and the swivel drives the sealing plate to rotate through the connecting plate, so that the diversion hole is opened. By setting the positioning rod and the sealing plate, the suction force in each puncture needle is guaranteed to be consistent, thereby ensuring Consistent synchronization of blood sampling across multiple needles.