14 results about "Venous blood sample" patented technology

The present invention relates to method for providing values of measured and / or estimated arterial oxygenation (SO2AM, SO2AE, SpO2) based on measuring values of blood acid / base status in a venous blood sample (VBGM, VBGE). A conversion of the venous blood values is made by applying a mathematical model for deriving blood acid / base status and oxygenation status into estimated or predicted arterial blood values (ABGP). Furthermore, if a value of measured and / or estimated arterial oxygenation value is below a corresponding venous oxygenation value, then estimating the arterial oxygenation value is made with a replacement value being a function of the corresponding venous oxygenation value. The advantage is that converting venous blood value to arterial blood values will be possible by providing arterialized blood gas and acid-base values for a higher percentage of clinical samples previously not possible.

The invention discloses a venous blood sampling fixing device for the part below the shank of a tumor patient and a using method, and belongs to the technical field of medical assistive devices. The device comprises a first plate body, and a first hydraulic rod and a second hydraulic rod are arranged below the first plate body at intervals. According to the scheme, limbs can be effectively stabilized, the blood sampling difficulty of the lower limbs is reduced, and the blood sampling success rate and the comfort level of a patient are improved.

The utility model discloses a disposable venous blood sample collection container which comprises a blood collection container. A sealing cover is installed at the top end of the blood sampling container, a rubber block is arranged in the sealing cover, and a protection mechanism is installed on the outer side of the blood sampling container. The protection mechanism comprises a clamping ring, a first arc plate, a second arc plate and a coil spring, the clamping ring is installed on the outer side of the blood sampling container, the first arc plate is rotatably installed at one end of the clamping ring, and the second arc plate is rotatably installed at the end, away from the first arc plate, of the clamping ring; the clamping ring, the first arc plate, the second arc plate and the coil spring are used in cooperation, the first arc plate and the second arc plate can rotate under the action of the coil spring by turning over the first arc plate and the second arc plate, one end of a blood sampling container can be supported through the clamping ring, the first arc plate and the second arc plate, and the blood sampling container is in an inclined state; the blood can better flow into the blood sampling container, so that medical staff do not need to hold the blood sampling container with hands, and the operation of the staff is facilitated.

The invention discloses a navigation system, a storage medium and a method for portal vein and branch vein puncture, and belongs to the technical field of medical instruments. The system comprises a modeling module used for constructing a three-dimensional blood vessel model containing a target belonging branch; the image fusion and navigation display module is used for performing registration fusion on the model and the intraoperative real-time image to generate an augmented reality navigation interface; the surgical instrument tracking and positioning module is used for acquiring and displaying the spatial pose of the instrument in real time; and the intelligent distinguishing module is used for analyzing the physical sensing signal of the instrument and automatically generating a distinguishing signal of entering a blood vessel cavity. The technical problems that an existing navigation system cannot clearly recognize deep branch blood vessels, is not intuitive in guidance and lacks objective successful criteria are solved, accurate, intuitive and intelligent surgical navigation of portal vein specific branches is achieved, and the system is particularly suitable for clinical scenes needing high-quality portal vein blood samples, such as free nucleic acid detection.

The invention relates to the field of medical health, in particular to a breast cancer liver metastasis risk dynamic monitoring and early warning system based on metabonomics, which comprises a data acquisition and preprocessing module for acquiring venous blood samples at three time points of disease progression of a patient, measuring specific metabolite concentration and performing normalization processing; the dynamic feature extraction module calculates a gain index, namely the sum of the change rates of the indexes; the deep learning modeling module uses the first and second deep networks to train sample data in different time periods, and establishes a patient disease prediction model. The comprehensive evaluation module adopts an ROC curve and an AUC value to evaluate the prediction accuracy of the model; the risk early warning module generates a liver metastasis risk early warning signal according to the evaluation result; according to the system, the breast cancer liver metastasis risk is dynamically monitored through metabonomics data acquisition and analysis at multiple time points, the metabolic change trend in disease progression is reflected more accurately, and early warning of the liver metastasis risk is achieved.

The utility model discloses an experimental rat and mouse venous blood sampling fixing device which comprises a plane base and a slope base, four limb fixing devices are arranged on the upper surface of the front portion of the plane base, a drain hole is formed in the upper surface of the rear portion of the plane base, and each limb fixing device comprises a first inverted-T-shaped fixing groove, a first bolt and a bandage. The first bolt is connected with the first inverted-T-shaped fixing groove, the bandage is connected to the first bolt, a second inverted-T-shaped fixing groove is formed in the slope base, the head fixing device is connected to the second inverted-T-shaped fixing groove, the head fixing device comprises a clamping base and a conical barrel fixed to the clamping base, and the clamping base is fixedly connected with the slope base through a second bolt. A third inverted-T-shaped fixing groove perpendicular to the second inverted-T-shaped fixing groove is formed in the slope base, and the clamping base and the second bolt can slide in the third inverted-T-shaped fixing groove. The fixing device is suitable for rats and mice of different body types, can effectively fix the rats and the mice, and facilitates vein blood sampling.

The invention discloses a system and method for evaluating the curative effect of RDN based on plasma rennin concentration change, the system comprises a baseline measurement module, a postoperative measurement module and a judgment module, the baseline measurement module is used for collecting an erect vein blood sample of a patient and measuring the baseline erect plasma rennin concentration of the patient on the day before the RDN operation; the postoperative measurement module is used for collecting a venous blood sample of a patient within 24 hours after the RDN operation is completed, and measuring the postoperative plasma rennin concentration of the patient; and the judgment module is used for calculating the change rate of the plasma renin concentration of the postoperative measurement module relative to the baseline measurement module, and comparing the change rate with a preset threshold value to judge whether the operation is effective or not. According to the invention, curative effect feedback can be provided within an extremely short time after an operation is finished, which is far earlier than blood pressure change after several months, and'gate advance 'of curative effect evaluation is realized. The invention provides an objective and quantitative standard (delta PRC%) based on blood biochemical indexes, and reduces the error of subjective judgment.

The invention discloses a detection method for diagnosing the health condition of ovarian cancer, and relates to the technical field of biomedical detection.The detection method comprises the steps that a venous blood sample of a patient is collected and subpackaged into a centrifugal tube, an exosome precipitation reagent is added, a blood cell layer is separated, and sterile exosome suspension and a CTC sample are obtained; capturing ovarian cancer specific exosomes based on the sterile exosome suspension, measuring the pressed sinking depth, and calculating the viscoelastic modulus; identifying a star-shaped structure of the ovarian cancer specific exosome, carrying out proportion quantification, and calculating a topological malignancy index; based on the customized scanning instruction, space-time modulation Raman scanning is carried out on the CTC sample, an original Raman spectrum space matrix is generated, spectral feature purification is carried out on the original Raman spectrum space matrix, and a metabolic disorder cell coordinate atlas is generated. According to the method, the star-shaped structure of the ovarian cancer specific exosome is recognized, the proportion is quantified, the topological malignancy index is calculated, the limitation of binary interpretation of a traditional marker is broken through, and dynamic gradient monitoring of the canceration process is achieved.

The invention discloses a cell analyzer mixing device and a mixing method. The cell analyzer mixing device comprises a device body, a main shaft is rotatably arranged on the device body, a fixing frame is fixed in the device body, a rotating shaft is rotatably arranged on the fixing frame, and the rotating shaft and the main shaft are in transmission connection through a gear transmission mechanism; a stirring rod is fixed to the rotating shaft, a stirring brush is fixed to the stirring rod, a movable frame is movably arranged in the device body, a plurality of clamping rings are fixed to the movable frame, test tubes are movably clamped in the clamping rings, and the movable frame is movably installed on the inner wall of the device body through a clamping assembly; an auxiliary shaft is rotationally arranged on the device main body and is in transmission connection with the main shaft through a belt transmission mechanism; and a plurality of cams are fixed on the auxiliary shaft. The invention relates to the technical field of cell blending devices, in particular to a blending device of a cell analyzer and a blending method, which can fully and effectively blend blood samples and diluents, are simple in structure and low in manufacturing cost, and can be applied to blending operation of common vein blood samples.

The invention provides a method for analyzing the growth performance of Tan sheep by using blood big data, and belongs to the field of data analysis and utilization. The method comprises the following steps: carrying out growth factor treatment on the Tan sheep; selecting a plurality of stages in the processing, respectively collecting a jugular vein blood sample in each stage for analysis, and collecting growth data for analysis; and judging whether the growth factor treatment has a promoting effect on the growth performance of the Tan sheep or not by combining the growth factor treatment, the blood indexes and the growth data. According to the method, whether the detected growth factor processing has a promoting effect on the growth performance of the Tan sheep is comprehensively judged through blood indexes and growth data, the effects of the growth performance of the Tan sheep of various growth factors can be effectively evaluated, and a systematic evaluation standard is established.

The invention discloses a polyadenylation functional site marker related to auxiliary diagnosis of non-small cell lung cancer and application of the polyadenylation functional site marker. The site is rs9606. Large-scale population data and biofunctional experiments prove that the rs9606 site affects the expression of the target gene LYRM4 by affecting the 3 'UTR length of the target gene LYRM4, and finally affects the risk of non-small cell lung cancer. According to the present invention, the rs9606 mutation detection can be performed on the normal population by using the real-time fluorescent quantitative PCR through the specific primer and probe design on the rs9606 site, such that the high risk population of the non-small cell lung cancer can be identified so as to assist the early screening and diagnosis of the non-small cell lung cancer patient. The technical method is reasonable in design, simple and feasible, detection can be carried out only by taking a venous blood sample of a patient, and invasive operation such as tissue biopsy is not needed. The method is accurate and reliable in result, can be popularized in hospitals at all levels, and is greatly helpful for evaluating the risk of non-small cell lung cancer.

FIELD: occupational medicine.SUBSTANCE: used to diagnose immunocompromise in workers exposed to mixed aerosols containing crystalline silicon dioxide from 10 to 70% and metals in the solid phase. Samples of venous blood and smears from the mucous membrane of the pharynx are taken. In the presence of Streptococcus pneumoniae DNA in scrapings from the mucous membrane of the pharynx and with the level of immunoglobulin M in the blood serum≤ 1.7 g / l is used to diagnose immunocompromise in workers exposed to mixed aerosols containing crystalline silicon dioxide from 10 to 70% and metals in the solid phase.EFFECT: method provides the possibility of selecting immunocompromised workers exposed to industrial mixed aerosols for priority vaccination against pneumococcal infection at the stage of periodic medical examination, by determining the level of immunoglobulin M in the blood serum and Streptococcus pneumoniae DNA in swabs from the mucous membrane of the pharynx.1 cl, 1 tbl, 1 ex

The invention relates to a computer-implemented method for compensating the effects of gas contamination of acid-base, oxygenation and / or electrolyte status for a venous blood sample, or blood sampled elsewhere, taken in a vacuum tube from a subject, such as human patient. The vacuum tube has a volume of residual gas (Vg) together with the blood. The method has a mathematical model with physiological sub-models simulating development in blood together with this residual gas, including sub-models describing: 1) the diffusion of gasses between the residual gas and the blood sample, 2) the effects of the diffusing gas in the blood in the vacuum tube, and 3) the effects of the diffusing gas in the residual gas in the vacuum tube. The mathematical model then calculates a modified set of blood variables (BV) to compensate for the physical and / or chemical interactions between the residual gasses and the blood sample in the time following sampling and before blood gas measurement. By accounting for this contamination of the blood sample, calculation of the actual values of blood variables seen in the patient is possible.

The invention relates to the technical field of hepatocellular carcinoma detection, and discloses a postoperative circulating tumor cell detection method based on hepatocellular carcinoma. The method comprises the following steps: collecting a venous blood sample within half an hour after a hepatocellular carcinoma patient, treating the venous blood sample with a red blood cell lysis solution to remove red blood cell components, and performing centrifugal separation to obtain a cell precipitate; embedding the precipitate in a paraffin matrix to form a cell paraffin block, and continuously slicing to obtain a slice sample to be detected; labeling surface antigens of the circulating tumor cells in the slices through specific antibodies by adopting an immunohistochemical technology; collecting a microscopic image of the marked sample, and extracting morphological characteristic parameters and dyeing intensity distribution data related to the circulating tumor cells; a recognition model is constructed based on the data, and positive circulating tumor cells and background interference signals are distinguished. The method is standard in process, achieves efficient detection of circulating tumor cells, and meets clinical requirements of hepatocellular carcinoma postoperative monitoring.