The invention discloses an automatic medicine dispensing device, which comprises a control module, an input module, an interaction module, a solvent module, a peristaltic pump module, a waste bin module and a lifting window component, wherein the input module, the interaction module, the solvent module and the peristaltic pump module are arranged in a medicine dispensing cavity located in the upper part of the automatic medicine dispensing device; the waste bin module and the lifting window component are arranged in a supporting cavity located below the medicine dispensing cavity. Through the automatic medicine dispensing cavity provided by the invention, the liquid injection on a penicillin bottle, the dissolution of a medication in the penicillin bottle and the suction of a liquid medicine can be automatically realized; after the medicine dispensation is completed, waste medicine bottle and needling instrument are discarded into the waste bin; therefore, the whole medicine dispensing process is automatically completed with high efficiency; meanwhile, the pollution of the liquid medicine, which is easily brought during manual operation, can be avoided; the safety is improved; a medical worker is also prevented from injuries from edge tools of the medication and the broken medicine bottle or a needle head and the like during the medicine dispensation.