The invention discloses a two-input and two-output networked decoupling control system large network time delay IMC method, and belongs to the MIMO-NDCS technology field having limited bandwidth resources. By aiming at influences and coupling between two-input and two-output signals, decoupling processing of TITO-NDCS is required, and because of the network time delay generated by transmission of network data among nodes, stabilities of various closed-loop control circuits are affected, and stability of a whole system is affected, and then the problem of the loss of the stability of the TITO-NDCS can be even caused. The method of using the process of the network data transmission among all of the actual nodes of the TITO-NDCS to replace a network time delay compensation model is provided, and two-freedom degree IMC and one-freedom degree are carried out on the two closed loop control circuits, and therefore the measurement, the estimation, or the identification of the network time delay among the nodes are eliminated, a requirement on synchronization of node clock signals is lowered, the influences of the network time delay on the stability of the TITO-NDCS are reduced, and system control performance quality is improved.