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Medicament for relieving alcoholism and protecting liver and preparation method thereof

A technology for anti-alcoholic and liver-protecting tablets, which can be used in medical formulas, medical preparations containing active ingredients, and nervous system diseases. Accurate and delay the effect of drunk time

Inactive Publication Date: 2009-08-26
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the composition and preparation method of anti-alcohol and liver-protecting products prepared from Hovenia dulcis, Pueraria lobata, and Schisandra as main raw materials have not been reported yet.

Method used

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  • Medicament for relieving alcoholism and protecting liver and preparation method thereof
  • Medicament for relieving alcoholism and protecting liver and preparation method thereof
  • Medicament for relieving alcoholism and protecting liver and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0060] The product composed of these three extracts can be properly added with necessary auxiliary materials (starch, sucrose, citric acid, magnesium stearate, mannitol, dextrin, etc.) in the preparation process. It can be in any pharmaceutically acceptable dosage form, or in any form of food acceptable product, and can be made into any dosage form by conventional methods, such as tablets, chewable tablets, capsules, granules, oral liquids, Granules, pills, powders, teabags, beverages and other oral dosage forms. Experimental example 1: Effects of prescription extracts on drunkenness and sobering up of mice

[0061] 50 Kunming male mice (Hubei Provincial Center for Disease Control and Prevention) weighing 18-22 g were randomly divided into 4 groups. There are 12 rats in each group, which are respectively set as the model control group and the small, medium and high dose groups of the prescription extract. The doses were 0.625, 1.25 and 2.5g of crude drug / kg, respectively, an...

experiment example 2

[0066] Experimental Example 2: Effects of Prescription Extracts on Alcoholic Liver Injury in Mice

[0067] Fifty Kunming male mice were randomly divided into 4 groups. There are 12 rats in each group, which are respectively set as the model control group and the small, medium and large dose groups of the prescription extract. Oral gavage with steamed water, once a day, for 7 consecutive days, 30-60 minutes after gavage on the last day, all four groups were given drunk doses of alcohol, and the animals were sacrificed after 6-10 hours of gavage, the liver was taken out and processed, and malondialdehyde was measured (MDA) content.

[0068] The experimental results (see table 2) show that, compared with the model control group, the liver MDA content of each administration group has a significant reduction, especially in the middle and large doses, which shows that this group can resist the excess of membrane lipids in the liver. Oxidation, and has obvious protective effect on ...

experiment example 3

[0072] Experimental Example 3: Effects of Prescription Extracts on Blood Alcohol Concentration in Mice

[0073] The method used in this experiment is headspace gas chromatography, which is currently the most accurate method for measuring blood alcohol.

[0074] Chromatographic conditions:

[0075] Chromatographic column: 4mm×2m stainless steel column, filled with 10% PEG20M, Chromosorb W (60-80 mesh)

[0076] 4mm×2m stainless steel column, built with GDX-201W (60~80 mesh)

[0077] FID detector and gasification chamber temperature: 150°C; column temperature: 100°C. Carrier gas (N 2 ) Flow rate: 45ml / min; H 2 : 35ml / min; Air: 300ml / min.

[0078] operate:

[0079] Add 0.5ml of serum, 0.5ml of internal standard solution, and about 1g of ammonium sulfate into a glass bottle (headspace bottle) of about 10ml, cover it with a polytetrafluoroethylene film and a rubber stopper, seal it with an aluminum cap, shake well, and place Heat in a water bath at 60°C for 15-20 minu...

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PUM

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Abstract

The invention discloses a medicament for relieving alcoholism and protecting liver and preparation method thereof, which is prepared by extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry. The steps are as follows: A. fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively crashed; B. reflux extraction is carried out by ethanol; C. filtering is carried out while hot; D. reflux extraction is carried out by ethanol; E. filtering is carried out while hot; F. the extracting solution is merged to carry out rotatory evaporation till no alcohol taste so that dry extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively obtained; G. ethanol is recovered; H. the three extracts are dried, displaced in a drier and cooled till room temperature so that dry extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry are respectively obtained; I. the dry extracts of fruit of Japanses raisintree, radices puerarire and shizandra berry are mixed. The method in the invention is simple and rapid, has high extraction yield and innocuous solvent and is applied to industrial production. The recipe clears heat and promotes diuresis, removes blood stasis and removes poisonous substance, cures liver and stomach diseases, has the functions of inhibiting absorption of alcohol, promoting evacuation of alcohol, and preventing liver oxidation damage due to alcohol, can strengthen human resistance to alcohol and reduce damage of alcohol for liver.

Description

technical field [0001] The invention relates to the field of medicine and health care, and more specifically relates to an anti-alcohol and liver-protecting agent, and also relates to a preparation method of the anti-alcohol and liver-protecting agent. Background technique [0002] Wine is a common beverage in human life. In our country, the unique "wine culture" makes our country's wine market huge and huge in consumption. The negative impact of "wine culture" is acute and chronic alcoholism. Acute heavy drinking can cause nausea, vomiting, memory loss, impairment of fine motor ability, and in severe cases, death can occur due to respiratory muscle paralysis. Studies have shown that among outpatients with acute poisoning, the number of acute alcohol poisoning ranks first or second in the number of emergency patients. Long-term drinking can lead to chronic alcoholism, which can cause fatty liver, alcoholic liver disease, cirrhosis, and even death. Alcoholism can also bri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/16A61P25/32
Inventor 汪晖李璐奕熊婕平洁张郦敖英
Owner WUHAN UNIV
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