Compound pharmaceutical composition for preventing and curing liver and gall syndrome of fish and preparation method thereof

Abstract

The invention relates to a compound pharmaceutical composition for preventing and curing liver and gall syndromes of fish and a preparation method thereof, belonging to the veterinary drug field. The compound pharmaceutical composition comprises rhubarb, cortex phellodendri, rhizoma coptidis, andrographis paniculata, gardenia, tarragon, liquorice, Vc, V[E], choline chloride, glucurone and talcum powder. The compound pharmaceutical composition of the invention can be used to effectively prevent and cure the liver and gall syndromes of fish, in particular to preventing and curing the liver and gall lesion of fish caused by bacterial infection liver and gall syndromes such as nutritional fatty liver, liver and gall enlargement, mosaic liver disease and the like with effective curative effect and no poison and side effect and the invention can not generate harmful drug residues for human health, can not be easy to generate drug resistance, can not pollute the environment and cause drug-induced diseases; the compound pharmaceutical composition is prepared by superfine pulverizing technology with small powder grain size, uniform distribution and quality, thus reducing drug dosage, saving medicinal material resources and reducing cost.

Description

technical field [0001] The invention relates to a compound medicinal composition for preventing and treating fish hepatobiliary syndrome and a preparation method thereof, belonging to the field of veterinary medicine. Background technique [0002] Fish hepatobiliary syndrome is one of the frequent fish diseases in recent years. It harms carp, crucian carp, grass carp, roundhead bream, herring, tilapia and other farmed fish. The epidemic season is from June to October. The mortality rate is high, up to more than 60%. If it is not treated in time, the mortality rate can reach 60%-90%, which has caused serious economic losses to the farmers. [0003] The pathological symptoms of fish hepatobiliary syndrome are typical symptoms of hepatomegaly and discoloration. In the early stage of diseased fish, the liver is slightly enlarged, slightly anemic, and the color is slightly light; the color of the gallbladder is darker, slightly green. With the development of the disease, the li...

AI Technical Summary

Problems solved by technology

Caused by nutrition: such as lack of choline, V E , Biotin, Inositol, V B etc., causing fat metabolism disorder in the fish, leading to fat accumulation in the liver and inducing pathological changes; or unreasonable nutritional ratio of feed, high protein content, high carbohydrate content in feed, or long-term use of animal fat and highly saturated fatty acid Etc., lead to excessive feed energy protein ratio, easy to induce liver fat accumulation, damage liver function, lead to the occurrence of hepatobiliary syndrome

Caused by poor management: if the feed is moldy and deteriorated, the toxic substances produced will directly harm the fish liver

In addition, the deterioration of the water quality environment makes it difficult to excrete the ammonia metabolites in the fish, which can also easily cause the metabolic imbalance of the fish and lead to the occurrence of liver and gallbladder diseases

At the same time, adding low-dose chemical drugs (tetracyclines, chloramphenicol, sulfonamides, flavomycin, etc.) to the feed for a long time or using fish drugs with large side effects and high residues (such as trichlorfon, copper sulfate, etc.) Cause fish liver and gallbladder damage, induce the occurrence of hepatobiliary syndrome

[0005] At present, in order to prevent the occurrence of fish hepatobiliary syndrome, pure Chinese herbal medicine is mainly used for prevention and treatment in China. Its advantages are safe use, no pollution, no residue, and it is not easy to produce drug resistance. Improve the body's disease resistance, but the effect is slow, and the common Chinese medicine powder has the problem of "thick, big, black", which makes the simple Chinese herbal medicine can play a certain role in prevention and treatment, but often cannot achieve satisfactory treatment after use Effect

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