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Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof

A technology for enteral nutrition preparations and active polysaccharides, which is applied in the directions of medical preparations containing active ingredients, food preparation, organic active ingredients, etc., can solve the problems of difficulty in ensuring the hygiene of homogenized meals, poor gastrointestinal tract, and increased energy consumption. , to achieve the effect of improving human immunity, enhancing resistance, and promoting iron absorption

Active Publication Date: 2013-04-03
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gastrointestinal function of leukemia patients is poor, especially during chemotherapy. Chemotherapy drugs inhibit the growth of gastrointestinal cells, causing adverse reactions such as loss of appetite, nausea and vomiting, abnormal taste, and increased energy consumption. Decreased resistance, in order to restore normal cells damaged by chemotherapy drugs, it is necessary to formulate food into high-calorie, high-protein, high-fiber and low-fat enteral nutrition preparations to overcome the lack of regular dietary nutrition and parenteral parenteral nutrition The shortcomings of the intestinal mucosal structure, absorption function and immune function suppression, and reduce the health of the traditional homemade homogenized meal in the hospital is difficult to guarantee and other problems

Method used

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  • Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof
  • Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof
  • Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1 kg of the whole viscera of Pinctada martensii was crushed with a high-speed tissue grinder, soaked twice in equal volume of acetone for 24 hours and 0.5 hours respectively, filtered out the acetone, dried in an oven at 60°C for 1.5 hours, and crushed for 60 hours. Mesh sieve to get acetone powder, hydrolyze with double enzyme method (pepsin hydrolysis conditions: enzyme dosage is 4%, enzymolysis temperature is 50 ℃, pH value is 2.0~2.5, and enzymolysis time is 4h; Bacillus subtilis neutral protease hydrolysis Conditions: enzyme dosage 6%, enzymolysis temperature is 50°C, pH value is 7.0, raw material: water is 1:10, enzymolysis time is 6h), boil to kill enzyme, decolorize with diatomaceous earth: activated carbon at 2:3 After alcohol precipitation, adjust pH 2.0 and pH 7.0 to remove protein, then dialyze with 50% ethanol, pH 6.5 for precipitation for 8 hours, wash with absolute ethanol, and vacuum dry at 40°C to obtain glycosaminoglycan.

[0032] Wash the raw oysters ...

Embodiment 2

[0036] Remove non-cartilage components from squid laryngeal cartilage, wash to obtain clean cartilage, crush, extract with 2% lye at a temperature of 50°C, and the ratio of solid to liquid is 1:4, then filter the filtrate and add 2% enzyme papain, the enzymolysis temperature is 55°C, the enzymolysis time is 8h, then alcohol precipitation, and the precipitate is vacuum freeze-dried to obtain squid chondroitin sulfate.

[0037] Get 0.8g of squid chondroitin sulfate prepared above, buy clam hydrolyzate 10g from Guangdong Xingyi Marine Bioengineering Co., Ltd., buy fish meat enzyme hydrolyzate 25g from Liangshan Ketai Biological Products Co., Ltd., and buy from Tianjin Yunhai International Trade Co., Ltd. Co., Ltd. purchased 40g of soybean protein isolate, 3.12g of kelp powder from Ningbo Chaoxing Marine Biological Products Co., Ltd., 18g of carrot powder from Tianjin Zhenruo Food Industry Co., Ltd., and konjac essence from Jiahua Import and Export Trading Company Powder 3g, purch...

Embodiment 3

[0040] Shark chondroitin sulfate 0.5g was obtained according to the method of Example 2, and the clam hydrolyzate 30g was obtained according to the method of Example 1, soy protein isolate 45g was purchased from Anyang Detianli Food Co., Ltd., from Qingdao Jinyou International Trade Co., Ltd. purchased 2.4g of kelp powder, 8.5g of spinach powder and 8.5g of citrus powder from Beijing Bauderui Food Co., Ltd., and 5g of konjac fine powder from Zhengzhou Lianchuang Food Trading Co., Ltd. Beijing Vita Company purchased 0.1 g of Na-Fe-EDTA.

[0041] The above-mentioned raw materials are gradually added from a small amount to a large amount, mixed evenly with a stirring mixer, vacuum-dried at 60°C, crushed through a 60-mesh sieve, and sterilized by a microwave at 800KW for 2 minutes to obtain the enteral nutrition preparation of the present invention.

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Abstract

An enteral nutrition comprises (mass%) marine bioactive polysaccharide 0.5-0.8%, enzymolysis article of shell fish meat 25-35%, fruit and vegetable powder 10-20%, and sodium-iron-EDTA 0.05-0.1%. The marine bioactive polysaccharide can be Pinctada martensii glycosaminoglycan, sea cucumber chondroitin sulfate or fishbone chondroitin sulfate. The enteral nutrition can further comprise soy protein isolate 35-45%, kelp powder 1-5% and refined konjak powder 3-5%. The enteral nutrition has high heat, high protein, high iron, low fat, multiple vitamins and easy absorbability. It is used as food for people needing much iron, especially for leukemia patient, bone marrow transplantation patient. It is also used with chemotherapy medicine to increase the curative effect of the medicine, improve the functions of gastrointestinal tract, enhance the immunity, and reduce side effects such as anemia and accompanying infection. Its preparation method includes that the raw materials are crushed with 60 meshes sieve and sterilized for 2 minutes with 800 kW power microwave after mixing and drying.

Description

technical field [0001] The invention relates to the field of food production, in particular to an enteral nutrition preparation containing marine biologically active polysaccharides, a preparation method and application thereof. Background technique [0002] During the treatment of leukemia patients, due to the progress of the disease, the application of chemotherapy drugs, psychological factors and other reasons, the food intake of the patients is reduced, and the body cannot obtain the necessary energy, which leads to the deterioration of the already extremely exhausted body and the formation of A vicious cycle. Therefore, it is very important to strengthen nutritional support for leukemia patients. However, the gastrointestinal function of leukemia patients is poor, especially during chemotherapy. Chemotherapy drugs inhibit the growth of gastrointestinal cells, causing adverse reactions such as loss of appetite, nausea and vomiting, abnormal taste, and increased energy c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/305
CPCA61K31/737A23V2002/00A23L1/3085A61K31/726A23L1/296A23L1/304A61K31/715A61K35/60A23L33/16A23L33/28A23L33/40A61P3/02A61P7/06A61P35/02A23V2250/2042A23V2250/1592A23V2250/5488A23V2250/21
Inventor 孙恢礼蔡冰娜孙谧吴园涛张偲陈忻陈华万鹏易湘茜戴文津孙小钰
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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