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A kind of chitosan hollow microcapsule and preparation method thereof

A technology for microcapsules and chitosan, applied in the field of chitosan hollow microcapsules and the preparation thereof, can solve the problems of damage to the integrity of the capsule wall, cumbersome preparation process, practical application limitations, etc., and achieves narrow particle size distribution and simple process. , the effect of increasing the scope of application

Inactive Publication Date: 2011-11-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The self-assembly method can obtain nanometer-sized hollow polymer microcapsules, but this method has strict requirements on the system and needs to be carried out at extremely low polymer concentrations, so their practical applications are greatly limited
The template synthesis method needs to remove the template of the "core-shell" capsule by physical or chemical methods, which will not only consume time and energy, but also cause varying degrees of damage to the integrity of the capsule wall.
The emulsion method is to use the novel technology in emulsion synthesis to synthesize hollow microcapsules. Although the application range of capsules has been greatly broadened, the preparation process is cumbersome.
In addition, in the existing technology of using chitosan to prepare microcapsules, most of the functional groups - amino groups are consumed by cross-linking agents such as glutaraldehyde, losing their functionality

Method used

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  • A kind of chitosan hollow microcapsule and preparation method thereof
  • A kind of chitosan hollow microcapsule and preparation method thereof
  • A kind of chitosan hollow microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 5g of chitosan with a degree of deacetylation of 90% is dissolved in 100ml containing 0.1mol / L acetic acid, and this solution is added in 100ml of liquid paraffin, which also contains an emulsifier: 0.05g of dodecylbenzenesulfonic acid Sodium and 0.05g surfactant (OP-10), above-mentioned solution is with emulsifying machine with 10 4 Disperse at the speed of rpm for 5 minutes, add 30ml of 0.1mol / L copper sulfate solution under mechanical stirring, add 2g of glutaraldehyde solution after 10 minutes, react at 40°C for 3 hours, filter the product, wash with ethanol and deionized water Put it into the chromatography column, wash it successively with 10ml 0.1mol / L hydrochloric acid solution, 10ml 0.1mol / L sodium hydroxide solution and 100ml deionized water, and dry the fully washed product to obtain the required hollow microsphere. Capsule (scanning electron micrograph, such as figure 1 , figure 2 shown), with an average diameter of 13 μm and a wall thickness of 0.2 μm. ...

Embodiment 2

[0034] 15g of O-hydroxyethylated chitosan with 98% degree of deacetylation is dissolved in 500ml of dichloroacetic acid containing 0.05mol / L, and this solution is added to the mixed solution of dichloromethane and toluene in a ratio of 1:1 In 500ml, also contain emulsifier in the mixed solution of this dichloromethane and toluene: 0.5g sodium lauryl sulfate and 0.2g Tween-85, above-mentioned solution is with emulsifying machine with 10 3 Disperse at the speed of rpm for 5 minutes, add 50ml of 0.9mol / L cobalt chloride solution under mechanical stirring, add 1g of glutaraldehyde and 1g of diphenylmethane diisocyanate after 10 minutes, react at 30°C for 5h, filter the product, After washing with ethanol and deionized water, put it into the chromatography column, wash it successively with 20ml 0.05mol / L hydrochloric acid solution, 20ml 0.05mol / L sodium hydroxide solution and 200ml deionized water, and wash the fully washed product The desired hollow microcapsules can be obtained a...

Embodiment 3

[0036] 2g degree of deacetylation is that 88% O-hydroxypropylated chitosan is dissolved in 300ml containing 0.5mol / L acrylic acid, this solution is added to isooctane and hexanaphthene mixed solution 300ml by 1: 1 ratio Among them, the mixed solution of isooctane and cyclohexane also contains emulsifier: 4g nonylphenol polyoxyethylene ether sulfate triethanolamine salt and 1g castor oil polyoxyethylene (90) ether, and the above-mentioned solution is mixed with an emulsifier at 10 5Disperse at the speed of rpm for 5 minutes, add 40ml of 0.5mol / L manganese chloride solution under mechanical stirring, add 2g of formaldehyde solution and 1g of toluene diisocyanate after 10 minutes, react at 45°C for 4 hours, filter the product, and remove it with ethanol and After washing with ionic water, put it into a chromatography column, wash it successively with 100ml 0.01mol / L hydrochloric acid solution, 100ml 0.01mol / L sodium hydroxide solution and 300ml deionized water, and dry the fully w...

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Abstract

The invention discloses a chitosan hollow microcapsule and a preparation method thereof. Prepare a solution in a weak acid, mix the above solution with a metal salt solution with a concentration of 0.1-1mol / L by mechanical dispersion or pressure, then add 1-10 parts of cross-linking agent, and react at 30-60°C for 0.5 ~5h. The microcapsules prepared by the present invention are in regular spherical shape, high hollowness, narrow particle size distribution (the diameter of the microcapsule is 100nm-1mm, and the thickness of the capsule wall is 30nm-10μm), good heat resistance, low density, large specific surface area, and Good surface penetration ability, and the method of the invention has simple process, high production efficiency, easy realization of large-scale preparation, and the capsule size and capsule wall composition can also be adjusted as required.

Description

technical field [0001] The invention relates to the field of hollow microcapsules, in particular to a chitosan hollow microcapsule and a preparation method thereof. Background technique [0002] Hollow microcapsules refer to capsule materials with a special structure ranging from nanometers to hundreds of microns. The hollow part can accommodate a large number of guest molecules or larger-sized guests. It has low density, large specific surface area, good stability, and surface Strong penetration ability and other characteristics. It has been widely used in chemistry, biology, material science and other fields, such as in drug controlled release, artificial cells, electrical components, catalysis, separation materials, coatings, acoustic sound insulation materials, etc. At present, the preparation methods of hollow microcapsules mainly include self-assembly method, template synthesis method and emulsion method. The self-assembly method can obtain nanometer-sized hollow pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14
Inventor 袁彦超赵建青刘述梅
Owner SOUTH CHINA UNIV OF TECH
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