Composition containing glucosamine as well as preparation method and detection method thereof

A technology of glucosamine and glucosamine sulfate, which is applied in the field of preparation of glucosamine-containing compositions, can solve the problems of long freeze-drying time, toxic and side effects, and high energy consumption, and achieve the effects of reducing side effects, reliable application, and satisfying industrial production
CN102961389AActive Publication Date: 2013-03-13任金山 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
任金山
Publication Date
2013-03-13

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Abstract

The invention relates to a composition containing glucosamine. The active ingredients of the composition are glucosamine or pharmaceutically acceptable salt thereof and lidocaine or pharmaceutically acceptable salt thereof, and the composition provided by the invention can be prepared into an injection, preferably a parenteral solution, more preferably a small-volume injection. The parenteral solution further comprises an antioxidant, a pH regulator and an alkaline solvent. The composition containing glucosamine provided by the invention can be used for overcoming the defects that freeze-drying preparation of glucosamine is long in freeze-drying time, high in energy consumption and not beneficial to production in the prior art and free-dying preparations in the same batch are different in the shape and solubility. Control on the stability of the parenteral solution and related substances is realized, and the side effect caused by degradation products is reduced, so that the safety and stability requirements of the parenteral solution are met. Therefore, the glucosamine parenteral solution provided by the invention can meet industrial production and can be safely and reliably applied to the field of medicine.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and particularly relates to a preparation method and application of a composition containing glucosamine. Background technique

[0002] Amino dextran is a natural sugar derived from chitin, which is the main component of the cartilage matrix. By changing its side chain structure, it is easier to combine with water in the articular cartilage to maintain the lubrication of the joint cavity and buffer pressure. It has a certain protective effect on damaged chondrocytes and can be artificially synthesized. Currently, glucosamine, glucosamine hydrochloride, glucosamine sulfate sodium chloride double salt or potassium chloride double salt are commonly used. Glucosamine is one of the smallest units that make up polyglucosamine, and it forms polyglucosamine with uronic acid, including chondroitin sulfate, keratan sulfate, dermatan sulfate and hyaluronic acid.

[0003] Amino dextran is a natura...

Claims

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