Hybrid template molecularly imprinted polymer as well as preparation method and application of hybrid template molecularly imprinted solid-phase extraction column

A technology of solid-phase extraction column and mixed template, which is applied in chemical instruments and methods, ion exchange, and other chemical processes, and can solve the problems of low actual recovery rate of analytes, harsh extraction and elution conditions, and incomplete treatment of impurities, etc. problems, to achieve the effect of high reproducibility, high recovery rate and high precision

Inactive Publication Date: 2013-11-20
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Problems solved by technology

[0009] The disadvantages of traditional solid-phase extraction are: (1) the actual recovery rate of the analyte is low; (2) the force between the solid-phase extraction and the adsorbent is non-specific, and the extraction and elution conditions are relatively harsh; (3) the selectivity is poor, and the treatment of impurities Incomplete, easy to cause column contamination; ⑷ can not be used repeatedly

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  • Hybrid template molecularly imprinted polymer as well as preparation method and application of hybrid template molecularly imprinted solid-phase extraction column
  • Hybrid template molecularly imprinted polymer as well as preparation method and application of hybrid template molecularly imprinted solid-phase extraction column
  • Hybrid template molecularly imprinted polymer as well as preparation method and application of hybrid template molecularly imprinted solid-phase extraction column

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Embodiment

[0033] 1. Preparation method of mixed template molecularly imprinted solid phase extraction column

[0034] Preparation of Molecularly Imprinted Polymers with Mixed Template Substances

[0035] Put bifentriazole (0.05mmol), myclobutanil (0.075mmol), diniconazole (0.075mmol) and 1.2mmol α-methacrylate (MAA) into a 50mL ampoule, add 15mL of acetonitrile to make it Reaction, ultrasonic vibration frequency 50kHz 1h, plus cross-linking agent EDMA 8mmol and initiator AIBN 0.02g. Ultrasonic at a vibration frequency of 50kHz for 30min, mix well and inject N 2 After deoxygenation for 15 minutes, vacuumize for 1 minute, seal it, and let it stand in a constant temperature water bath at 55°C for 24 hours to obtain block-like solid imprinted polymer (MIP). After grinding and crushing, pass through a 200-mesh sieve, wash and settle with water for 3 times, (when the upper layer water is clear,) remove the fine powder. The final MIP particles were eluted with methanol:acetic acid (volume r...

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Abstract

The invention relates to the field of chemical synthesis, analytical chemistry and supermolecular chemistry, and particularly relates to a hybrid template molecularly imprinted polymer as well as a preparation method and an application of a hybrid template molecularly imprinted solid-phase extraction column. Conventional food and feed sample pre-treatment technologies mainly comprise liquid-liquid extraction and Soxhlet extraction and have the disadvantages of long treatment time, complex operation, unstable recovery rate, poor repeatability, poor selectivity, large consumption of organic solvents, environmental pollution, easiness in emulsification, difficulty in realization of automation and the like. The preparation method mainly comprises the following steps of: selecting an appropriate ratio of a template matter to a functional monomer; synthesizing a hybrid template molecularly imprinted polymer; preparing the hybrid template molecularly imprinted solid-phase extraction column. The hybrid template molecularly imprinted solid-phase extraction column is mainly applied to the purification and enrichment of samples during residue analysis of bitertanol, myclobutanil and diniconazole.

Description

technical field [0001] The invention relates to the fields of chemical synthesis, analytical chemistry and supramolecular chemistry, in particular to a preparation method and application of a mixed template molecularly imprinted polymer and a solid-phase extraction column thereof, mainly used for the analysis of triazole fungicide residues in food and feed Sample purification and enrichment. Background technique [0002] Bifentriazole, myclobutanil and diniconazole all belong to the triazole fungicides, which are broad-spectrum systemic fungicides, mainly used to prevent Venturia ) and Sclerotinia ( Sclerotinia ) caused by fruit tree diseases, and coccidiomycetes ( Mycosphaerella ) caused by banana disease and peanut leaf spot; [0003] According to the Chinese pesticide toxicity classification standard, triazole fungicides belong to low-toxicity fungicides, and acute oral LD ​​in rats 50 ﹥4000mg / kg, acute oral LD ​​in male mice 50 About 2000mg / kg. Excessive use will...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/28B01J20/26B01J20/30B01D15/08
Inventor 高文惠刘博
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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