Method for preparing degradable biomedical magnesium alloy/calcium-phosphorus coating composite material

Abstract

The invention relates to a method for preparing a degradable biomedical magnesium alloy / calcium-phosphorus coating composite material. The method comprises the specific steps: cutting magnesium alloy into samples in moderate sizes, polishing by sequentially using 800# alumina waterproof sandpaper and 2,000# alumina waterproof sandpaper so as to remove an oxide layer from the surface of magnesium alloy, carrying out ultrasonic cleaning for 5-30 minutes by sequentially using deionized water and anhydrous ethanol, and drying at room temperature for later use; preparing a conversion solution from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, controlling the mole ratio of calcium to phosphorus to be (1:1) to (2: 1), controlling the concentration of Ca<2+> to be 0.01-0.2M, and controlling the concentration of P<5+> to be 0.01-0.2M; putting base body samples obtained through pretreatment into the conversion solution, and soaking for 5-100 hours, thereby obtaining calcium-phosphorus coating layers; carrying out performance detection. According to the method, magnesium-alloy base bodies are subjected to ultrasonic pretreatment firstly, so that the bonding performance between the calcium-phosphorus coating layers and the surfaces of the base bodies is better; the calcium / phosphorus mole ratio of the conversion solution used by the method is 1-2, and the concentration of both calcium and phosphorus is higher than that of an ordinary bionic solution, so that the efficiency of chemical conversion can be increased obviously, and a calcium-phosphorus product is closer to human bone ingredients.

Description

technical field [0001] The invention relates to a preparation method of a degradable biomedical magnesium alloy / calcium phosphorus coating composite material. Background technique [0002] Biomedical metal materials currently used in clinical practice mainly include stainless steel, cobalt-chromium alloy, and titanium alloy. These metal materials have good corrosion resistance, but there are also several potential problems, such as poor biocompatibility. After implantation in the body, it is easy to produce toxic ions harmful to the physiological environment due to friction and slight degradation, and because these metal materials generally have good mechanical properties, they will produce stress shielding effects in the tissue repair process. In addition, these metal materials Due to its non-degradability, it needs to be removed by secondary surgery, which increases the pain of patients and the burden of medical expenses. To solve the above problems, an important means is...

AI Technical Summary

Problems solved by technology

[0004] However, as a new type of bone tissue engineering material, magnesium alloy material has two important scientific problems in its research and application, which greatly restricts its further development in the medical field, making it impossible to realize the commercialization of medical magnesium alloy.

These two problems are: (1) Material science: too fast degradation of magnesium and its alloys in vivo will also lead to too fast decay of mechanical properties of degradable magnesium alloy bone tissue devices in vivo, which will affect the effect of repair and reconstruction; There is still a lack of research on the material design of degradable magnesium alloys for human applications; the change in the mechanical strength of magnesium alloys during the degradation process in the body is also an important content that needs further research; in view of the special mechanical properties of magnesium alloys compared with other metals, for the use of degradable magnesium alloys The device preparation process and technology for degrading magnesium alloys also need to be developed and evaluated