A class of near-infrared fluorescent dyes based on rhodamine and its preparation method and application

A fluorescent dye and near-infrared technology, applied in luminescent materials, fluorescence/phosphorescence, coumarin dyes, etc., can solve the problems of large Stokes shift, application limitations, short absorption and emission wavelengths, etc.
CN103468018BActive Publication Date: 2017-03-08TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2017-03-08

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Abstract

The invention discloses a rhodamine based near-infrared fluorescent dye having the following structural formula (I), wherein Y is O or S; Z is NR6R7 or OR8; R1, R2, R6, R7 and R8 respectively independently are hydrogen, alkyl, ether group, substituted alkyl, acyl, or aryl; R3, R4, R5, R9, R10 and R11 independently are hydrogen, low alkyl, lower alkoxy, cyanogroup or halogen; R12, R13, R14, R15 and R16 independently are hydrogen, low alkyl, lower alkoxy, halogen, formyl, formate group, sulfonic group, sulfonate grop, sulfonyl chloride group, formic acid ester group, formyl halide group, formamide group, hydroxyl, amino, cyanogroup, isocyanate group, isothiocyanate group or amine group; X is a negative ion. The invention also discloses a preparation method of the rhodamine based near-infrared fluorescent dye. The rhodamine based near-infrared fluorescent dye has good biocompatibility and photostability, low toxicity, long fluorescence emission and high fluorescence quantum yield, and can be used in covalent fluorescent labeling of biological macromolecules and fluorescent probe fluorophore.
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Description

technical field

[0001] The invention relates to a class of near-infrared fluorescent dyes and their preparation methods and applications, in particular to a class of rhodamine-based near-infrared fluorescent dyes and their preparation methods and applications. Background technique

[0002] In recent years, it is of great significance to the development of fields such as revealing the mysteries of life, clinical diagnosis and drug screening, and fluorescence imaging is becoming an important technology in biological research. This is mainly due to the emergence of more and more fluorescent probes, including small molecule fluorescent probes, nano-quantum dots, and fluorescent proteins. Fluorescent protein tracer technology has been widely used in biomedical research. However, fluorescent proteins have problems such as large molecular weight, large steric hindrance, and interference caused by protein-protein interactions. The safety of nano-quantum dots has always been uncertai...

Claims

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