Composition for treating atherosclerosis

A technology of atherosclerosis and composition, applied in the field of compositions for preventing and treating atherosclerosis, can solve the problems of reducing cholesterol content, reducing triglyceride concentration, increasing liver function index and the like

Inactive Publication Date: 2014-08-13
古天津
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(1) Bile acid binding resin prevents the absorption of bile acid in the gastrointestinal tract, so as to increase the compensatory use of cholesterol in the liver to produce bile acid, and reduce the content of cholesterol in liver cells, but side effects such as gastrointestinal discomfort (diarrhea, constipation) may occur
(2) Fibrous acid derivatives reduce the concentration of triglycerides in the blood, which may cause side effects such as abdominal pain, diarrhea, nausea, vomiting, and increased liver function index
(3) Nicotinic acid derivatives can reduce the concentration of low-density lipoprotein, triglyceride, and cholesterol, and increase the concentration of high-density lipoprotein, but have gastrointestinal discomfort, high uric acid, gout, rash, liver function Side effects such as index increase, if taken for a long time may increase the chance of gallstones
(1) Vitamin K antagonists include Warfarin (former rodenticide), dicoumarol, etc., whose chemical structure is similar to vitamin K, and whose mechanism of action is to antagonize vitamin K-dependent blood coagulation factors II, VII, IX, Active reaction of X, but side effects such as hematuria, gastrointestinal tract and intracerebral hemorrhage will occur
(2) Heparin is composed of D-glucosam

Method used

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  • Composition for treating atherosclerosis
  • Composition for treating atherosclerosis
  • Composition for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0030] -Inhibitory activity of citral on proliferation of human aortic smooth muscle cells-

[0031] In order to analyze whether citral inhibits the proliferation activity of human aortic smooth muscle cells (abbreviated as "smooth muscle cells") (hereinafter referred to as "inhibitory activity"), WST-1 reagent was used to measure the proliferation and cell viability of smooth muscle cells. WST-1 reagent is a tetrazolium salt that can be cleaved into formazan by mitochondrial dehydrogenase in living cells. First, smooth muscle cells were implanted into a 96-well culture dish, and after being cultured to 70% full, the smooth muscle cells were replaced with DMEM medium containing 0.5% bovine embryonic serum for "synchronization" for 24 hours. Smooth muscle cells were stimulated with 30 μg / ml oxidized low-density lipoprotein (ox-LDL) for 24 hours with or without the addition of citral compound. Finally, WST-1 reagent was added to the cell culture medium, and the total amount of ...

experiment example 2

[0043] -Effect of citral on the proliferation rate of smooth muscle cells treated with oxidized low-density lipoprotein-

[0044] Such as figure 2 As shown, after being stimulated by 30μg / ml oxidized low-density lipoprotein, about 50% of smooth muscle cells proliferated. Compared with the experimental group treated only with oxidized low-density lipoprotein, the proliferation rate of cells treated with 1, 2.5 and 5μg / ml citral was significantly reduced, and the effect was dose-dependent.

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Abstract

The invention discloses a composition for treating atherosclerosis. The composition is characterized by comprising geranialdehyde used as an effective component, wherein the geranialdehyde is from lemon myrtle, litsea cubeba, cubeb litsea tree, lemon grass and lemon tea tree, wherein the concentration of the geranialdehyde is 1-51g/ml. The pharmaceutical composition containing the geranialdehyde has an unequal inhibition effect on hyperplasia of human aortic smooth muscle cells stimulated by lipopolysaccharide. Compared with the geranialdehyde and other flavonoid compounds, the composition has the best activity, can inhibit hyperplasia of human aortic smooth muscle cells caused by oxidized low-density lipoprotein, does not have toxicity on cells, and can inhibit inflammatory response.

Description

technical field [0001] The invention relates to a composition for preventing and treating atherosclerosis. Background technique [0002] Cardiovascular disease is a syndrome of the heart and blood vessels. Cardiovascular disease can be divided into coronary heart disease, cerebrovascular disease, peripheral arterial occlusive disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis and pulmonary embolism. Coronary arteriosclerosis may cause angina, myocardial infarction or sudden death, cerebral or carotid arteriosclerosis may lead to renal hypertension or even uremia, and peripheral arteriosclerosis may lead to aneurysm or obliterative arteriosclerosis. Therefore, arteriosclerosis is inseparable from cardiovascular disease. [0003] Because the cause of atherosclerosis is hyperlipidemia or blood coagulation, such as lipopolysaccharide activated cytokine TNF-α, This in turn stimulates smooth muscle cell proliferation and increases the production ...

Claims

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Application Information

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IPC IPC(8): A61K31/11A61P9/10
Inventor 古天津李玉芬
Owner 古天津
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