Lotion and use thereof

A technology of lotion and conditioner, which is applied in the field of medicine, can solve the problems of female reproductive system flora imbalance, loss, underwear pollution, etc., and achieve the effect of comprehensively regulating the microecological balance of the vagina or skin

Inactive Publication Date: 2014-09-03
符耿哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Clinically, for the treatment of gynecological diseases, antibiotics and antiviral drugs are often given, or some traditional Chinese medicines with antibacterial and antiviral effects are used. Defect: The recurrence rate is particularly high, and it will lead to the imbalance of flora in the female reproductive system, especially the loss of beneficial bacteria, which will bring deeper pain to patients. Therefore, it is of great significance to research and develop new preparations
[0004] Chinese patent 201310275625.4 discloses a gel containing chitosan polymers, hyaluronic acid substances, and lactic acid substances. The application will bring some pollution to the patient's underwear, causing a new burden for the patient; while the lotion is more convenient to apply before bathing or going to bed, and the lotion has fast transdermal absorption and better effect

Method used

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  • Lotion and use thereof
  • Lotion and use thereof
  • Lotion and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1 group to embodiment 7 groups of lotions.

[0071] Test method: HPV infection specimen preparation: The specimens taken from the outpatient clinic of the hospital (the HPV type is HPV16, HPV18 and HPV52 mixed types, belonging to the high-risk mucosal type) collected from the outpatient clinic of the hospital were collected into a centrifuge tube, weighed 30 mg, and mixed with glass. Homogenize with a mixer, add 5ml of normal saline, and make a 6mg / ml in vitro suspension for later use.

[0072] Sample processing method: use a pipette gun to draw 50 μl of sample solution and 50 μl of specimen suspension into a 15ml centrifuge tube, shake evenly, so that the sample and specimen can fully interact, culture in a 37°C water bath, and treat the specimen for 1 day , 3 days, 5 days, and 7 days later, one group was taken for the following test.

[0073] Extraction of HPV-DNA: Take out the sample-treated sample suspension from the water bath, and extract DNA according...

Embodiment 7

[0095] Table 7 embodiment 7 products are to the MIC and MBC of standard bacterial strain

[0096]

[0097] As can be seen from the above table, the lotion of the present invention is effective to the selected Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Proteus vulgaris, Streptococcus faecalis, Neisseria gonorrhoeae selected by the test. Both the marked strains and the clinical reference strains of Gardnerella vaginalis have obvious inhibitory and inactivation effects, and their MBC is 2 to 4 times that of the MIC.

Embodiment 4

[0098] Embodiment 4: anti-herpes virus effect

[0099] Experimental cells and viruses: human liver cancer Hep-2 cells and HSV-II virus were provided by the Institute of Virology, School of Medicine, Wuhan University.

[0100] Test animals: female clean-grade Kunming mice, weighing 17±1g.

[0101] (1) Anti-virus test method: take 0.8×10 5 / mL concentration of Hep-2 cells, added to a 24-well plate, 37 ° C, 5% CO 2 Culture in the incubator for 24 hours, after the cells grow into a single layer, discard the supernatant, add 1000TCID 50 / mL of HSV-II, 0.1mL / well, 37°C, 5% CO 2 , adsorbed for 90min, discarded the supernatant, added drug-containing maintenance solution to be tested, and repeated 4 wells for each drug. 37°C, 5% CO 2 After culturing for 33 hours, the virus inhibition rate was detected by MTT method.

[0102] Inhibition rate = (average OD value of drug-dosed wells - average OD value of solvent wells) × 100% / average OD value of solvent wells.

[0103] Test results...

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Abstract

The invention belongs to the technical field of medicine, and discloses a lotion and use thereof, and the lotion comprises a chitosan polymer, a hyaluronic acid, a pH regulator, a cosolvent and a transdermal enhancer; the lotion has good stability, and the study shows that the lotion is good in antibacterial effect, wide in antibacterial spectrum (propionibacterium acnes and the like resisting), wide in resistant virus (including high-risk HPV (human papilloma virus), low risk HPV, herpes virus), physical antimicrobial, free of drug resistance, biodegradable, safe, environmentally friendly, and long in drug efficacy duration time, and has the nourishing, lubricating, whitening, spot fading, repairing, scar formation inhibiting, and anti-adhesion effects on skin or mucosal tissues. The lotion is safe and non-toxic, and has the effects of resisting bacteria, repairing, moisturizing, and full recovery of vaginal or skin micro ecological balance.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a lotion containing chitosan polymers, hyaluronic acid substances and pH regulators and uses thereof. Background technique [0002] Diseases of the female reproductive system are gynecological diseases, including vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, ovarian diseases, etc. Gynecological diseases are common and frequently-occurring diseases of women. However, because many people lack proper understanding of gynecological diseases, lack of health care for the body, and various bad living habits, the physical health is deteriorating, causing some women to suffer from diseases that cannot be cured for a long time, which brings great harm to normal life and work. Big inconvenience. [0003] Clinically, for the treatment of gynecological diseases, antibiotics and antiviral drugs are often given, or some traditional Chinese medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/20A61K47/18A61K47/10A61K31/728A61P31/02A61P31/22A61P15/00A61P31/04A61P31/10A61P33/14A61P17/02A61L15/28A61L15/44A61K31/722
Inventor 符耿哲吴刚康晓飞
Owner 符耿哲
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