A kind of synthetic method of 25-hydroxycholesterol

A technology of hydroxycholesterol and its synthesis method, which is applied in the fields of steroids and organic chemistry, and can solve problems such as difficult industrialization, Hg residue, and difficult operation, and achieve convenient operation and post-processing, mild reaction conditions, and post-processing simple effect
CN104130306BActive Publication Date: 2016-05-18ZHEJIANG UNIV OF TECH +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2016-05-18

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Abstract

The present invention discloses a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw material, which undergoes an addition reaction with a hydroxyl containing reagent in an organic solvent under catalysis, and then hydrolyzing the reaction product and separating to obtain 25-hydroxy cholesterol. The present invention adopts hydroxyl containing reagents such as water, formic acid, acetic acid, propionic acid, butyric acid, benzoic acid, p-methyl benzoic acid to replace the commonly used extremely toxic reagents such as Cr reagent, Hg reagent and polyfluorinated acetone in the prior art. The raw materials of the present invention are easily available, and have low effect on environment. The operation and post treatment are convenient. Moreover, the method has the advantages of mild reaction conditions, simple operation, good selectivity, high efficiency, high yield, simple post treatment, easy product separation, less three wastes and easy industrialization.
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Description

technical field

[0001] The invention belongs to the technical field of intermediate synthesis, and in particular relates to a synthesis method of 25-hydroxycholesterol. Background technique

[0002] 25-hydroxycholesterol for the synthesis of 25-hydroxyvitamin D 3 An important raw material, 25-hydroxyvitamin D 3 Also known as calcifediol, vitamin D 3 The active metabolite has stronger physiological activity and does not need to be metabolized by the liver. It Has More Than Regular Vitamin D 3 All functions also have the following unique functions: ①Some human or animals cannot synthesize vitamin D due to liver dysfunction 3 Direct conversion to 25-hydroxyvitamin D 3 , even with more vitamin D intake 3 Nor can it be absorbed. Therefore 25-hydroxyvitamin D 3 As an active substance, it bypasses liver transformation and is directly absorbed by humans or animals; ② 25-hydroxyvitamin D 3 Used in animals, it can promote the bone development of poultry animals, promote the m...

Claims

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