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In-vivo degradable and absorbable artificial medical tissue repairing film

A tissue repair and artificial technology, applied in the direction of prosthesis, medical science, etc., can solve the problems of unfavorable tissue repair, unfavorable tissue repair and application, easy swelling of silicone rubber, etc.

Inactive Publication Date: 2015-03-18
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1094066A discloses a chitosan composite membrane containing carbon fiber and its preparation process, but the mechanical properties of the membrane are poor; repair membranes such as nylon and polyester cannot be degraded and absorbed, and will remain in the body for a long time to become foreign matter
Although the silicone rubber-absorbable bioprotein biomeningeal repair patch reported by CN1830492B can avoid the direct contact of silicone rubber and tissue, after bioprotein degradation and metabolism, silicone rubber remains in the body as a foreign body and causes hemolysis, and silicone rubber is easy to swell and become Lead to poor compressive strength, which is not conducive to tissue repair
Although the non-woven fabric prepared by the electrospinning technology reported by CN101507843A can be completely degraded, it cannot guarantee the complete removal of the antigen because it contains collagen
The in vivo absorbable repair membranes reported so far still have disadvantages such as too fast degradation speed, which is not conducive to tissue repair and application.

Method used

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  • In-vivo degradable and absorbable artificial medical tissue repairing film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Dissolve copolyglycolide / lactide (PLGA) with a molecular weight of 50,000 in chloroform to make a 5% solution, then add porogen sodium chloride with the same weight as PLGA, stir well and inject polytetrafluoroethylene For vinyl molds, first volatilize the solvent at normal temperature and pressure, and then soak in distilled water to dissolve the porogen after the solvent volatilizes into a hard solid; change the soaking solution several times until no chloride ions are detected. The sponge from which the porogen was removed was dried at room temperature under vacuum for 1-3 days to remove moisture, and a sponge-like porous structure layer with a thickness of 1.0 mm was obtained. After the porous structure layer was treated with oxygen plasma, it was immersed in an aqueous solution of penicillin for 1 hour, taken out, frozen at -20°C, and then dried in a freeze dryer for 48 hours to load penicillin. Dissolve poly-L-lactic acid (PLLA) with a molecular we...

Embodiment 2

[0038] Example 2 Dissolve polycaprolactone / polyethylene glycol block copolymer (PCE) with a polyethylene glycol block molecular weight of 2000 and a molecular weight of 80,000 in dioxane to make a 10% solution; then add 5-Fluorouracil with an amount of 0.01% of the mass of PCE is stirred evenly and poured into a polytetrafluoroethylene mold, freeze-shaped at -20°C, freeze-dried in a freeze dryer for 48 hours, and then vacuum-dried at room temperature for 48 hours to obtain a thickness A 2.0mm artificial tissue repair membrane porous structure layer. After the porous structure layer was treated with plasma oxygen plasma, soaked in erythromycin ethanol solution for 1 hour, the porous structure layer was taken out, frozen at -20°C, and dried in a freeze dryer for 48 hours to load penicillin. Dissolve copoly(lactide / caprolactone) (PLC) with a molecular weight of 150,000 in chloroform to make a 10% solution, scrape the film on a polytetrafluoroethylene plate, and evaporate th...

Embodiment 3

[0039] Example 3 Dissolve polycaprolactone / polyethylene glycol block copolymer (PCE) with a polyethylene glycol block molecular weight of 4000 and a molecular weight of 80,000 in chloroform to prepare a 3% solution, which is prepared by electrospraying 0.2mm thick porous structure layer. After treating the porous structure layer with plasma oxygen plasma, soak it in the aqueous solution of growth factor BMP for 1 hour, take out the porous structure layer, freeze at -20°C, and dry it in a freeze dryer for 48 hours to obtain a BMP load of PCE One ten thousandth of the porous structure layer. Dissolve poly DL-lactic acid (PDLLA) with a molecular weight of 200,000 in acetone to make a 10% solution, scrape the film on a polytetrafluoroethylene plate, volatilize the solvent at room temperature and pressure to form a film, and then dry it in vacuum at room temperature 1-3 days to ensure that the solvent is completely removed to obtain a dense structure layer with a thickness o...

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Abstract

The invention provides an in-vivo degradable and absorbable artificial medical tissue repairing film and a preparation method thereof. The biodegradable repairing film is composed of a porous layer and a reinforcing layer and is a sponge-like substance which is of a two-layer, three-layer or multi-layer overlapped structure, wherein the layers are closely combined. The porous layer has a certain thickness so that the biodegradable repairing film has a certain shape and a certain drug loading capacity so as to meet the needs of tissue repair; the reinforcing layer is compact and has reinforcing and anti-tearing effects; each layer of structure can be prepared from different raw materials at different ratios and loaded with different drugs according to treatment requirements; the degradation speed and drug release can be controlled by controlling the quantity and size of holes. The porous layer is higher than the reinforcing layer in degradation speed, so that the repairing film keeps a certain mechanical strength within a certain time and the drug is released slowly and directionally. The repairing film is excellent in operability and suturing property, nontoxic, degradable and absorbable in vivo, good in biocompatibility, free of injuries to tissues, applicable to various surgical repair operations and suitable for popularization and implementation.

Description

technical field [0001] The invention relates to a medical biodegradable and absorbable artificial tissue repair film and a preparation method thereof. [0002] The repair membrane is made of the same or different synthetic polymer materials or natural polymer materials. The tissue repair membrane is composed of a spongy porous drug-loaded layer and a dense surface layer. It has a certain tear strength and excellent Biocompatibility, biodegradability and targeted drug release performance. Background technique [0003] With the development of medical technology, artificial surgical repair device materials have become commonly used medical devices in surgery, such as membranes used for repairing pleural and peritoneal repairs, pericardial repairs, dura mater repairs, and bladder repairs. The materials currently used as tissue repair membranes are mainly biogenic membranes from natural tissues, including autologous membranes, heterologous membranes, and heterogeneous membranes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61L27/54A61L27/58A61L27/16A61L27/18A61L27/24A61L27/20
Inventor 张海军王身国杨飞常立娜
Owner SHANDONG BRANDEN MEDICAL DEVICE
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