Glucosamine composite tablets and preparation method thereof

A technology of glucosamine and compound tablets, applied in food preparation, sugar-coated pills, drug combination and other directions, can solve the problems of slow absorption by the human body, single efficacy, poor product disintegration, etc., and achieves easy absorption, short process time, and good fluidity. Effect

Inactive Publication Date: 2015-05-20
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And this invention only relies on the combination of glucosamine and calcium to treat and prevent osteoporosis and osteoarthritis. Poor decomposability, slow absorption by human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Take 675.0mg of glucosamine sulfate (about 500mg of glucosamine), 400.0mg of chondroitin sulfate, 200.0mg of collagen, 200.0mg of dimethyl sulfone, 120.0mg of calcium carbonate particles (about 40mg of calcium), mineral premix Ingredients 80.0mg (about 1.5mg of boron-containing agent, 1.5mg of manganese-containing agent, 1.5mg of copper-containing agent), 8.0mg of olive oil, 2.0mg of vitamin D3, 2.0mg of sodium hyaluronate, 10.0 mg of sodium carboxymethylcellulose, Crospovidone 10.0mg, silicon dioxide 10.0mg, magnesium stearate 8mg, PVA 20mg, HPMC 13mg, vanilla essence 4mg, stearic acid 3mg for later use.

[0046] Prepare as follows:

[0047] Step 1: Prepare a 1-25% aqueous solution of the adhesive, fully dissolve until clear and transparent, and the adhesive is sodium carboxymethyl cellulose;

[0048] Step 2: crush the glucosamine through a 60-120 mesh sieve;

[0049] Step 3: Put the glucosamine, stabilizer and part of the remaining binder into the wet granulator and...

Embodiment 2

[0058] Take 675mg of glucosamine sulfate (containing about 500mg of glucosamine), 300.0mg of chondroitin sulfate, 100.0mg of collagen, 100.0mg of dimethyl sulfone, 100.0mg of calcium carbonate particles (about 33mg of calcium agent), mineral premix 50.0mg (about 1.0mg of boron-containing agent, 1.0mg of manganese-containing agent, 1.0mg of copper-containing agent), 2.0mg of olive oil, 1.0mg of vitamin D3, 2.0mg of sodium hyaluronate, 5.0 mg of sodium carboxymethylcellulose, and Lipovidone 5.0mg, silicon dioxide 5.0mg, magnesium stearate 5mg, PVA 10mg, HPMC 6.5mg, vanilla essence 2mg, stearic acid 1.5mg for later use.

[0059] Prepare as follows:

[0060] Step 1: Prepare a 1-25% aqueous solution of the binder, fully dissolve until clear and transparent, preferably the binder is sodium carboxymethyl cellulose;

[0061] Step 2: crush the glucosamine through a 60-120 mesh sieve;

[0062] Step 3: Put the glucosamine, stabilizer and part of the remaining binder into the wet granul...

Embodiment 3

[0071] Take 800.0mg of glucosamine sulfate (about 600mg of glucosamine), 450.0mg of chondroitin sulfate, 300.0mg of collagen, 300.0mg of dimethyl sulfone, 250.0mg of calcium carbonate particles (about 75mg of calcium), mineral premix Ingredients 150.0mg (about 3.0mg of boron-containing agent, 3.0mg of manganese-containing agent, 3.0mg of copper-containing agent), 30.0mg of olive oil, 5.0mg of vitamin D3, 5.0mg of sodium hyaluronate, 30.0 mg of maltodextrin, cross-linked polymer Vitamin ketone 30.0mg, silicon dioxide 30.0mg, magnesium stearate 15mg, PVA 40mg, HPMC 26mg, vanilla essence 8mg, stearic acid 6mg for later use.

[0072] Prepare as follows:

[0073] Step 1: Prepare a 1-25% aqueous solution of the adhesive, fully dissolve until clear and transparent, and the adhesive is maltodextrin;

[0074] Step 2: crush the glucosamine through a 60-120 mesh sieve;

[0075] Step 3: put glucosamine, stabilizer and another binder into the wet granulator and stir for 1-10 minutes, and m...

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PUM

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Abstract

The present invention discloses glucosamine composite tablets and a preparation method thereof, and belongs to the field of purposes of health food. On the basis of combination of glucosamine and calcium supplements, the glucosamine complex tablets further comprise active ingredients comprising the following materials: 100 to 400 parts of chondroitin sulfate, 100 to 400 parts of dimethyl sulfone, 100 to 400 parts of collagen, 1 to 40 parts of olive oil, 1 to 5 parts of sodium hyaluronate, and other auxiliary materials which comprise the following materials: 1 to 5 parts of a glidant, 1 to 5 parts of a lubricant and 1 to 10 parts of a coating premix agent. A mineral premix agent includes 1 to 5 parts of a boron agent, 1 to 5 parts of a manganese agent and 1 to 5 parts of a copper agent. The glucosamine complex tablets are further added with active ingredients with effects of enhancing cartilage, joint synovial fluid and bone density. The preparation method of the glucosamine complex tablets adopts a wet granulation process, and adequately overcomes problems of single product efficacy, low absorption and utilization rate in conventional glucosamine type health food.

Description

technical field [0001] The invention belongs to the field of health food applications, and in particular relates to a glucosamine compound tablet for treating and preventing osteoarthritis and osteoporosis and a preparation method thereof. Background technique [0002] Glucosamine is a natural amino monosaccharide. It is the most important monosaccharide that constitutes polyglucosamine (GS) and proteoglycan in the matrix of articular cartilage. It is an important nutrient for the formation of chondrocytes and a natural tissue component of healthy articular cartilage. With age, the lack of glucosamine in the human body becomes more and more serious, the articular cartilage degenerates and wears continuously, and the joint tissue will be severely worn, and glucosamine can protect and strengthen the cartilage structure and prevent joint function caused by joint aging invalidated. It can also produce proteoglycan to lubricate joints, prevent bone and joint friction pain, and m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A61K38/39A61P19/02A61P29/00A61P19/10A61K31/737A61K31/728A61K31/7008A61K31/10A61K33/10A61K31/59A23L29/30A23L33/125
CPCA61K38/39A23V2002/00A61K9/2027A61K9/2054A61K9/2806A61K31/10A61K31/59A61K31/7008A61K31/728A61K31/737A61K33/10
Inventor 张涛边立锋张国栋
Owner JIANGSU ALAND NOURISHMENT
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