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Adsorbent, preparation method thereof, and resin containing long-chain quaternary ammonium salt

A technology of adsorbent and quaternary ammonium salt, which is applied in the field of strong basic anion exchange resin, can solve the problems of decreased adsorption performance of adsorbent, discomfort reaction of related personnel, carcinogenic toxicity and other problems, and achieves the effect of increasing yield

Inactive Publication Date: 2015-12-09
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, chloromethyl ether has serious carcinogenic toxicity and has been banned by many countries in the world. Therefore, it is necessary to find a method for preparing a strong basic anion exchange resin that does not use chloromethyl etherification.
In addition, the current ion exchange resins for bilirubin adsorption are all directly chloromethylated and reaminated on the polystyrene backbone, so the hydrophilic and strongly basic ionic groups are directly connected to the hydrophobic polymer backbone. , which reduces the hydrophobicity of the polystyrene backbone, which is not conducive to the adsorption of free bilirubin or unconjugated bilirubin bound to albumin
In addition, the strong basic ion-exchange groups directly connected to the hydrophobic polymer backbone have poor thermal stability, and the decomposition of quaternary ammonium salts will not only lead to a decrease in the adsorption performance of the adsorbent, but also produce a special foul smell, resulting in Relevant personnel will experience discomfort during production and clinical use

Method used

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  • Adsorbent, preparation method thereof, and resin containing long-chain quaternary ammonium salt
  • Adsorbent, preparation method thereof, and resin containing long-chain quaternary ammonium salt
  • Adsorbent, preparation method thereof, and resin containing long-chain quaternary ammonium salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] When preparing the adsorbent, first prepare 4-chlorobutyrylstyrene monomer, such as figure 2 Shown, the preparation process of 4-chlorobutyrylstyrene monomer is as follows:

[0047] First, add 100ml of chlorobutyryl chloride, 200ml of dichloroethane, and 1g of anhydrous ferric chloride into a 1L three-necked flask. Then slowly add 100ml of styrene dropwise at a rate of 1 drop / second to 3 drops / second under stirring conditions, while controlling the system temperature at 25±5°C, and keep the room temperature after the dropwise addition to continue the reaction for 5.5 hours. Then, after the reaction is completed, add an ice-water solution of hydrochloric acid to wash away ferric chloride in a liquid separation manner, and remove the solvent and raw materials not involved in the reaction by distillation under reduced pressure. Finally, it is separated and purified to obtain 4-chlorobutyrylstyrene monomer.

[0048] Such as image 3 Shown, the preparation process of pol...

Embodiment 2

[0056] The preparation process of the polystyrene-based macroporous resin matrix in this example is as follows: first, 800 ml of an aqueous solution containing 1.5 wt % gelatin and 3 wt % sodium chloride was added to a 2 L three-necked flask. Then add 10g of divinylbenzene, 8.2g of ethylstyrene, 61.8g of styrene, 20g of 4-chlorobutyrylstyrene, 125g of isooctyl alcohol, 25g of butyl acetate, and 1g of lauryl peroxide. The organic phase. Then, the temperature was raised to 68° C. for 5 hours for polymerization under mechanical stirring, and the temperature was raised to 80° C. for 10 hours to stop the reaction after curing. Then wash off the porogen iso-octanol with methanol, then wash with water until the washing solution is clear, filter with suction, and sieve. Finally, a resin with a particle size in the range of 0.3 mm to 0.6 mm is selected to obtain the polystyrene-based macroporous resin matrix containing 4-chlorobutyrylphenyl in this embodiment.

[0057] Other experime...

Embodiment 3

[0060] The preparation process of the polystyrene-based macroporous resin matrix in this example is as follows: first, 800 ml of an aqueous solution containing 1.5 wt % gelatin and 3 wt % sodium chloride was added to a 2 L three-necked flask. Then add 12g divinylbenzene, 9.8g ethylstyrene, 48.2g styrene, 30g 4-chlorobutyrylstyrene, 120g isooctyl alcohol, 40g butyl butyrate, 1g lauryl peroxide The organic phase. Then, the temperature was raised to 68° C. for 5 hours for polymerization under mechanical stirring, and the temperature was raised to 80° C. for 10 hours to stop the reaction after curing. Then wash off the porogen iso-octanol with methanol, then wash with water until the washing solution is clear, filter with suction, and sieve. Finally, a resin with a particle size in the range of 0.3 mm to 0.6 mm is selected to obtain the polystyrene-based macroporous resin matrix containing 4-chlorobutyrylphenyl in this embodiment.

[0061] Other experimental procedures and metho...

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Abstract

The invention provides an adsorbent, a preparation method thereof, and resin containing long-chain quaternary ammonium salt. The adsorbent is used to adsorb bilirubin in blood purification. The adsorbent comprises strong-basic anion exchange resin containing long-chain quaternary ammonium salt. The exchange resin comprises at least one quaternary ammonium salt group and polystyryl macroporous resin matrix, and the quaternary ammonium salt group and polystyryl macroporous resin matrix are connected through a butyryl substituted group. The resin has the advantages of high thermal stability and good absorbing performance. The preparation method of adsorbent comprises the following steps in sequence: preparing 4-butyryl chloride substituted styrene, preparing polystyryl macroporous resin matrix, preparing strong-basic anion exchange resin containing long-chain quaternary ammonium salt, and preparing adsorbent. The preparation method is more environment-friendly, and moreover, the ion exchange capacity can be precisely controlled by controlling the weight ratio of 4-butyryl chloride substituted styrene to other monomers.

Description

technical field [0001] The invention relates to the field of blood purification and polymer chemistry, in particular to an adsorbent for absorbing bilirubin in blood purification and a preparation method of the adsorbent, and also to a strong basic anion containing long-chain quaternary ammonium salts Exchange resin. Background technique [0002] Bilirubin is a kind of bile pigment. It is the main pigment in human bile and is orange-yellow. It is the main metabolite of heme in the body. It is toxic and can cause irreversible damage to the brain and nervous system. The bilirubin in normal human serum is mainly divided into two types: one is the bilirubin combined with glucuronic acid or other substances through the action of the endoplasmic reticulum of liver cells, called conjugated bilirubin; It is mainly from the bilirubin produced by the destruction of red blood cells in the mononuclear phagocyte system. In the plasma, it is mainly combined with albumin and transported, ...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30B01J41/12C08F212/08C08F212/14C08F212/12C08F212/36C08F8/44A61M1/36B01J41/14
Inventor 董凡邵柯
Owner JAFRON BIOMEDICAL
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