Dialysate adsorbing filler, preparation method and application of dialysate adsorbing filler

A technology for adsorbing fillers and dialysate, applied in dialysis systems, chemical instruments and methods, and adsorbed water/sewage treatment, etc., can solve problems such as complex pipelines, heavy burden on microporous membranes or filters, and high frequency of membrane replacement. The effect of risk reduction, risk reduction and maintenance cost

Active Publication Date: 2016-01-06
北京北九环境技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding microporous membranes or filters will inevitably lead to more complicated pipelines. At the same time, since the total amount of dialysate circulation is about 10-50L, the number of cycles of dialysate through the adsorbent box is about 20-100 times per day, which will generate a large amount of Fine particles, the burden on the microporous membrane or filter is very heavy, the replacement frequency of the membrane is high, and the maintenance cost is high

Method used

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  • Dialysate adsorbing filler, preparation method and application of dialysate adsorbing filler
  • Dialysate adsorbing filler, preparation method and application of dialysate adsorbing filler
  • Dialysate adsorbing filler, preparation method and application of dialysate adsorbing filler

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Effect test

Embodiment 1

[0042] The preparation of embodiment 1 hot melt adhesive solid material compound

[0043] The preparation steps are:

[0044] 1) Add 20 mg of gelatin to 20 mL of water, heat and dissolve to obtain a clear aqueous solution;

[0045] 2) Keep the temperature of the gelatin aqueous solution above 50°C, add zirconium phosphate solid powder into the gelatin aqueous solution, the mass ratio of gelatin and solid material is 1:400, stir for 1 hour,

[0046] 3) Keep stirring, cool to room temperature, collect solids, wash with deionized water, and dry.

[0047] The obtained solid is the composite material of zirconium phosphate and gelatin.

[0048] Using the same method, other kinds of composite adsorption materials were prepared respectively. The polymer is: agar powder, agarose, carrageenan, guar gum, pectin, safflower gum, tragacanth gum, konjac powder, polyvinyl alcohol and other hot sols or a combination of several; the solid material is: Zirconia, Zirconium Carbonate, Magnesi...

Embodiment 2

[0049] Embodiment 2pH adjusts the preparation of hydrogel solid material composite

[0050] Dissolve 20mg of sodium alginate in 20mL of water, add 20g of zirconium phosphate to it, stir evenly, slowly add hydrochloric acid dropwise, adjust the pH value of the solution to 3, keep stirring for 1 hour, filter, and wash with deionized water until neutral , collecting the solid to obtain a composite adsorption material of zirconium phosphate and alginic acid.

[0051] Using the same method, other kinds of composite adsorption materials were prepared respectively. Polymer materials are: potassium alginate, ammonium alginate, hyaluronic acid, carboxymethyl cellulose, carboxymethyl chitosan, polyacrylic acid and its salt derivatives; solid materials: zirconium oxide, zirconium carbonate, phosphoric acid Magnesium, alumina, titanium oxide, silica gel, diatomaceous earth, montmorillonite and activated carbon.

Embodiment 3

[0052] Embodiment 3 Preparation of amino-containing hydrogel and solid composite material

[0053] Take 20mg of chitosan and dissolve in 20mL of acetic acid aqueous solution (2%, v / v), add 20g of zirconium phosphate therein, after stirring evenly, slowly add sodium carbonate aqueous solution dropwise, adjust the pH value of the solution to 9.5, keep stirring for 1 hour , filtered, washed with deionized water, and the solid was collected to obtain a composite material of chitosan and zirconium phosphate.

[0054] Using the same method, other chitosan composite adsorption materials were prepared respectively. Solid materials: zirconia, zirconium carbonate, magnesium phosphate, aluminum oxide, titanium oxide, silica gel, diatomaceous earth, montmorillonite and activated carbon.

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Abstract

The invention provides a dialysate adsorbing filler. The adsorbing filler is a composite formed by gluing macromolecule materials outside solid materials, wherein the solid materials are particles being 0.1micrometer to 1mm and are selected from one or a combination of silicon-based adsorbing materials, zirconium-based adsorbing materials, magnesium-based inorganic adsorbing materials, aluminum oxide, titanium oxide, other metal or composite metal oxides, montmorillonite, activated carbon and other adsorbing materials; the macromolecule materials are one of polysaccharide macromolecules, protein macromolecules, polyvinyl alcohol, polyacrylic acid and derivatives, or multiple mixed macromolecules and cross-linked polymers. According to the dialysate adsorbing filler provided by the invention, hydrogel or viscoloid is formed by utilizing macromolecules in the materials, and is used for packaging or gluing solid adsorbing materials, the adsorbing capability of the materials is kept, meanwhile, the seepage of fine particles of the adsorbing materials can be effectively controlled, and the risk of dialysis treatment can be lowered.

Description

technical field [0001] The invention belongs to the separation field of substance adsorption and exchange process, and in particular relates to a dialysis material and its preparation and application. Background technique [0002] Renal dysfunction or renal failure is a disease that gradually loses renal function. With the development of the disease, it will cause the patient's acid-base balance and electrolyte ion balance to be disturbed. Excessive body fluids cannot be excreted, and harmful metabolites include urea, creatinine, Uric acid and phosphorus accumulate in body tissues, leading to the death of the patient. Dialysis is a renal replacement therapy for patients who have lost most or all of their renal function, including peritoneal dialysis and hemodialysis. In the traditional dialysis treatment process, the peritoneum or dialyzer is mainly used to diffuse the toxins in the blood in the body to the external dialysate, flow away with the dialysate, and discharge exc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/26B01J20/30A61M1/16C02F1/28
CPCA61M1/16B01J20/24B01J20/26B01J20/30C02F1/28
Inventor 李建中刘自军
Owner 北京北九环境技术有限责任公司
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