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A kind of dialysate adsorption filler, its preparation method and application

A technology for adsorbing fillers and dialysate, applied in dialysis systems, chemical instruments and methods, adsorption water/sewage treatment, etc. Effectiveness of risk reduction, risk reduction and maintenance cost

Active Publication Date: 2017-08-04
北京北九环境技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding microporous membranes or filters will inevitably lead to more complicated pipelines. At the same time, since the total amount of dialysate circulation is about 10-50L, the number of cycles of dialysate through the adsorbent box is about 20-100 times per day, which will generate a large amount of Fine particles, the burden on the microporous membrane or filter is very heavy, the replacement frequency of the membrane is high, and the maintenance cost is high

Method used

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  • A kind of dialysate adsorption filler, its preparation method and application
  • A kind of dialysate adsorption filler, its preparation method and application
  • A kind of dialysate adsorption filler, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 hot melt adhesive solid material compound

[0043] The preparation steps are:

[0044] 1) Add 20 mg of gelatin to 20 mL of water, heat and dissolve to obtain a clear aqueous solution;

[0045] 2) Keep the temperature of the gelatin aqueous solution above 50°C, add zirconium phosphate solid powder into the gelatin aqueous solution, the mass ratio of gelatin and solid material is 1:400, stir for 1 hour,

[0046] 3) Keep stirring, cool to room temperature, collect solids, wash with deionized water, and dry.

[0047] The obtained solid is the composite material of zirconium phosphate and gelatin.

[0048] Using the same method, other kinds of composite adsorption materials were prepared respectively. The polymer is: agar powder, agarose, carrageenan, guar gum, pectin, safflower gum, tragacanth gum, konjac powder, polyvinyl alcohol and other hot sols or a combination of several; the solid material is: Zirconia, Zirconium Carbonate, Magnesi...

Embodiment 2

[0049] Example 2 Preparation of pH-adjusted hydrogel solid material composite

[0050] Dissolve 20mg of sodium alginate in 20mL of water, add 20g of zirconium phosphate to it, stir evenly, slowly add hydrochloric acid dropwise, adjust the pH value of the solution to 3, keep stirring for 1 hour, filter, and wash with deionized water until neutral , collecting the solid to obtain a composite adsorption material of zirconium phosphate and alginic acid.

[0051] Using the same method, other kinds of composite adsorption materials were prepared respectively. Polymer materials are: potassium alginate, ammonium alginate, hyaluronic acid, carboxymethyl cellulose, carboxymethyl chitosan, polyacrylic acid and its salt derivatives; solid materials: zirconium oxide, zirconium carbonate, phosphoric acid Magnesium, alumina, titanium oxide, silica gel, diatomaceous earth, montmorillonite and activated carbon.

Embodiment 3

[0052] Embodiment 3 Preparation of amino-containing hydrogel and solid composite material

[0053] Take 20mg of chitosan and dissolve in 20mL of acetic acid aqueous solution (2%, v / v), add 20g of zirconium phosphate therein, after stirring evenly, slowly add sodium carbonate aqueous solution dropwise, adjust the pH value of the solution to 9.5, keep stirring for 1 hour , filtered, washed with deionized water, and the solid was collected to obtain a composite material of chitosan and zirconium phosphate.

[0054] Using the same method, other chitosan composite adsorption materials were prepared respectively. Solid materials: zirconia, zirconium carbonate, magnesium phosphate, aluminum oxide, titanium oxide, silica gel, diatomaceous earth, montmorillonite and activated carbon.

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Abstract

The present invention discloses an adsorption filler for a dialysate, and the adsorption filler is a composite of a solid-state material having a high polymer material adhered thereto. The solid-state material is in the form of particles between 0.1 μm to 1 mm, and is selected from one and combinations of adsorption materials, including a silicon-based adsorption material, a zirconium-based adsorption material, a manganese-based inorganic adsorption material, a metal oxide or composite metal oxide, such as aluminum oxide and titanium oxide, montmorillonite, activated carbon, etc. The high polymer material is one or more of mixed high polymers or cross-linked polymers, including a polysaccharide polymer, a protein polymer, polyvinyl alcohol, polyacrylate, and a derivative thereof. The adsorption filler for a dialysate disclosed in the present invention uses the high polymer in the filler to form a hydrogel or a tacky colloid wrapping or adhering to the solid-state adsorption material, such that superior adsorption capability of the material is retained while leakage of fine particles of the adsorption material is effectively controlled, thereby reducing the risk of a dialysis treatment.

Description

technical field [0001] The invention belongs to the separation field of substance adsorption and exchange process, and in particular relates to a dialysis material and its preparation and application. Background technique [0002] Renal dysfunction or renal failure is a disease that gradually loses renal function. With the development of the disease, it will cause the patient's acid-base balance and electrolyte ion balance to be disturbed. Excessive body fluids cannot be excreted, and harmful metabolites include urea, creatinine, Uric acid and phosphorus accumulate in body tissues, leading to the death of the patient. Dialysis is a renal replacement therapy for patients who have lost most or all of their renal function, including peritoneal dialysis and hemodialysis. In the traditional dialysis treatment process, the peritoneum or dialyzer is mainly used to diffuse the toxins in the blood in the body to the external dialysate, flow away with the dialysate, and discharge exc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L1/00B01J20/24
CPCA61M1/16B01J20/24B01J20/26B01J20/30C02F1/28
Inventor 李建中刘自军
Owner 北京北九环境技术有限责任公司
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