Method of preparing hydroxyapatite by mechanochemical method

Abstract

The invention discloses a method of preparing hydroxyapatite by a mechanochemical method. The method comprises the steps that according to a mole ratio that Ca / P is equal to 1 to 2, adding a calcareous material and microcosmic salt into a ball miller, and ball-milling to obtain a mixture; then mixing the mixture with water, introducing CO2 gas, and reacting for 20 to 120min; or transferring the mixture and the water into a reaction kettle, and reacting for 5 to 30h under the temperature of 50 to 150 DEG C; after the reaction is ended, filtering and drying to obtain hydroxyapatite powder. The calcareous material is pretreated by means of a mechanical activation technology, so that a defected is generated on a structure, reaction activation energy is reduced, reactivity is enhanced, and reaction with the microcosmic salt is promoted; the mixture after the reaction is ended reacts with CO2 or is subjected to heat reaction with water for further edulcoration and crystallization, the crystallinity and the purity of the hydroxyapatite are improved, the technological process is simple, the reaction conditions are mild, and large-scale industrial production is easy.

Description

technical field [0001] The invention belongs to the field of inorganic synthesis, in particular to a method for preparing hydroxyapatite by mechanochemical method. Background technique [0002] Hydroxyapatite (HAP) is a high value-added bio-inorganic material with good biocompatibility and bioactivity. It has been extensively studied and applied in the field of hard tissue repair or replacement. In addition, HAP also has the characteristics of high surface activity, selective adsorption, unique pore structure, and high chemical stability. It has broad application prospects in the fields of sewage treatment, drug carriers, separation and purification, and industrial catalysis, and has great research. Develop and exploit value. [0003] At present, the preparation methods of HAP mainly include chemical precipitation method, sol-gel method, hydrothermal synthesis method, microemulsion method, solid phase reaction method and template method. The dry method usually uses tricalc...

AI Technical Summary

Problems solved by technology

The reaction temperature of this method is relatively high, the heat treatment time is relatively long, and the performance after sintering is relatively poor, so it is not suitable for industrial production

The preparation temperature of the wet method is lower than that of the dry method, but there are also some insurmountable shortcomings

The chemical process of the sol-gel method is relatively complicated, the price of the alkoxide raw material is quite expensive, the toxicity of the organic solvent is high, and it is easy to cause pollution to the environment, etc.

In terms of morphology control of hydroxyapatite powder, nano-hydroxyapatite with various structures (nanometer microspheres, nanofibers, nanocolumns) has been synthesized, but during the synthesis process, templates or surfactants need to be added , these additives can easily pollute the final product and affect the purity of hydroxyapatite

In summary, the current preparation of hydroxyapatite is mostly limited to the use of chemical raw materials and organic templates, and the synthesis temperature is high and the process is complicated. In addition, to obtain hydroxyapatite powder with specific morphology and structure, it is necessary to add Extraneous substances, affecting purity

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