Preparation method for chain extender used for structurally antibacterial polyurethane

A technology of polyurethane and chain extender is applied in the field of preparation of chain extender for structural antibacterial polyurethane, which can solve the problems of tissue cell toxicity, lack of biological selectivity, lack of long-term effect, etc. Reduced toxicity, wide application effect

Inactive Publication Date: 2016-11-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these antibacterial agents will be continuously released during the use of polyurethane products and lack long-term effect; in addition, many antibacterial agent molecules lack bioselectivity. When they are dissolved from polyurethane products, they can effectively kill harmful microorganisms such as bacteria. At the same time, it also has a toxic effect

Method used

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  • Preparation method for chain extender used for structurally antibacterial polyurethane

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Example Embodiment

[0023] Example 1

[0024] (1) Vinylation of ciprofloxacin: mix 10 parts of ciprofloxacin, 4 parts of triethylamine and 300 parts of dichloromethane uniformly, stir at 0°C for 30 minutes, and then add dropwise under continuous stirring and nitrogen protection 4 parts of acryloyl chloride, after the dripping is completed, the temperature is raised to 20°C for 1 hour; after the reaction is completed, the above mixture is poured into n-hexane, the precipitate is repeatedly washed with water and dried to obtain vinyl ciprofloxacin;

[0025] (2) Dihydroxy functional modification of vinylated ciprofloxacin: Dissolve 3 parts of vinylated ciprofloxacin, 1 part of diethanolamine and 0.5 part of triethylamine in 200 parts of methanol, and react at 40°C for 6 Hours; after the reaction, the methanol was distilled under reduced pressure to obtain a yellow viscous solid, which was washed with anhydrous acetone, and the remaining solid was dried to obtain a dihydroxy chain extender containing cipr...

Example Embodiment

[0027] Example 2

[0028] (1) Enoxacin vinylation: mix 12 parts of enoxacin, 5 parts of pyridine and 360 parts of tetrahydrofuran uniformly, stir at 2°C for 40 minutes, and then add 5 parts of acryloyl chloride dropwise under continuous stirring and nitrogen protection After the dripping is completed, the temperature is raised to 25°C for 1.5 hours; after the reaction is completed, the above mixture is poured into cyclohexane, and the precipitate is repeatedly washed with water and dried to obtain vinylated enoxacin;

[0029] (2) Dihydroxy functional modification of vinylated enoxacin: 30 parts of vinylated enoxacin, 10 parts of dibutanolamine and 6 parts of pyridine are dissolved in 300 parts of ethanol, and reacted at 45°C for 8 Hours; after the reaction, the ethanol is distilled under reduced pressure to obtain a yellow viscous solid, which is washed with anhydrous acetone, and the remaining solid is dried to obtain a dihydroxy chain extender containing enoxacin pendant groups. ...

Example Embodiment

[0031] Example 3

[0032] (1) Norfloxacin vinylation: 20 parts of norfloxacin, N,N -Mix 8 parts of diisopropylethylamine and 500 parts of ethyl acetate uniformly, stir at 5°C for 60 minutes, and then add 8 parts of acryloyl chloride dropwise under the protection of nitrogen under continuous stirring. After the addition, heat to 35°C and react 2.5 Hours; after the completion of the reaction, pour the above mixture into n-heptane, and the precipitate is repeatedly washed with water and dried to obtain vinylated norfloxacin;

[0033] (2) Dihydroxy functional modification of norfloxacin vinyl: Dissolve 300 parts of vinyl norfloxacin, 100 parts of diisopropanolamine and 18 parts of potassium carbonate in 800 parts of chloroform at 60°C React for 24 hours; after the reaction, the chloroform is distilled off under reduced pressure to obtain a yellow viscous solid, which is washed with anhydrous acetone, and the remaining solid is dried to obtain a dihydroxy chain extender containing norfl...

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Abstract

The invention discloses a preparation method for a chain extender used for structurally antibacterial polyurethane. The preparation method comprises the following steps: subjecting fluoroquinolone to vinylation modification by using an acylation reaction; and then introducing a dihydroxyl group into vinylated fluoroquinolone molecules according to the principles of the Michael addition reaction so as to obtain the dihydroxyl chain extender with an antibacterial fluoroquinolone group in its side chain. The chain extender is applicable to synthesis of solvent type or waterborne polyurethane for preparation of structurally antibacterial polyurethane, endows a polyurethane product with lasting and long-acting antibacterial and mildew-resistant performance without influence the main chain structure of polyurethane, and has application prospects in the fields of leather/synthetic leather coatings, bio-medical instruments, etc.

Description

technical field [0001] The invention relates to a preparation method of a chain extender for structural antibacterial polyurethane, which belongs to the field of antibacterial materials. Background technique [0002] Polyurethane is a kind of synthetic material with a wide range of uses. Its industrial production is based on polyvalent isocyanate and various hydrogen donor compounds (such as polyether and polyester with terminal hydroxyl groups) as basic raw materials, and is produced through gradual addition polymerization. have to. By selecting different types of monomer raw materials, controlling the number and proportion of functional groups and adopting different synthesis processes, polyurethane products with different structures, properties, processing methods, appearance and application forms can be prepared, which have been widely used. It is used in various industries and fields such as agriculture, electronics, textiles, medical treatment, construction, transport...

Claims

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Application Information

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IPC IPC(8): C08G18/32C07D215/56C07D471/04
CPCC08G18/3848C07D215/56C07D471/04
Inventor 陈意常金明范浩军严孙贤杨高夫王忠辉
Owner SICHUAN UNIV
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