Sodium alginate nanofiber as well as large-scale electrospinning preparation method and application thereof

Abstract

The invention discloses a sodium alginate nanofiber as well as a large-scale electrospinning preparation method and application thereof. A sodium alginate micro-nanofiber is prepared by an airflow-assisted electrospinning method, wherein the content of sodium alginate in the micro-nanofiber is 75% or higher; the fiber diameter is 50-900 nm; the sodium alginate nanofiber is prepared according to the air-assisted electrospinning method; airflow same as a spinning jet direction is provided by a gas producing mechanism in the spinning process, so as to accelerate the evaporation of a solvent and promote the formation of spun silk; the sodium alginate nanofiber is simple in preparation method, low in requirement on spinning conditions, high in yield, and suitable for large-scale production; spinning precursor liquid is simple in formula, without adding a cross-linking agent and an irritant or toxic solvent; the content of sodium alginate in the obtained nanofiber is high, so that the sodium alginate nanofiber has significant advantage in application in fields of biological tissue engineering materials, wound repair materials or beauty and cosmetics.

Description

technical field [0001] The invention relates to a sodium alginate nanofiber and its large-scale electrospinning preparation method and application, belonging to the field of micro-nano materials. Background technique [0002] Sodium Alginate is a linear polyuronic acid extracted from natural brown algae. The main chain of the molecule is composed of a-L-mannuronic acid (M unit) and b-D-guluronic acid (G unit). - Copolymers linked by 1,4-glycosidic bonds and composed of GM, MM and GG fragments in different proportions. As a linear, non-toxic natural polymer polyelectrolyte, sodium alginate has the characteristics of low cost, wide source of raw materials, good biodegradability and biocompatibility, etc. It has great potential in drug release system, tissue engineering and pharmaceutical fields. Wide range of applications. At present, gelling agents, thickeners, stabilizers, and emulsifiers prepared from sodium alginate have been widely used in the food industry, such as col...

AI Technical Summary

Problems solved by technology

However, there are mainly the following problems in the preparation of sodium alginate nanofibers by electrospinning technology: (1) sodium alginate is an anionic polyelectrolyte, and its aqueous solution has high conductivity. The positive ions and negative ions in the electrospinning process tend to move in opposite directions. During the electrospinning process, a stable tangential electric field cannot be maintained on the surface of the droplet, thereby reducing the tangential electric field force and making it difficult for the Taylor cone to form a jet; (2 ) Sodium alginate solution will produce gelation phenomenon at very low concentration (such as 2% aqueous solution). At such a low concentration, the amount of solute is very small, and it is difficult to form an effective fiber structure. The sprayed droplets or short fibers embedded in the beads, and the concentration increases slightly, the viscosity will increase rapidly, causing the spinning solution to be too viscous to form a continuous jet; (3) the G unit in sodium alginate It causes its molecular chain to form a rigid extended chain, while the G unit is combined by a double bond and fixed by a hydrogen bond. The rigid and extended molecular chain of sodium alginate prevents the aqueous solution from forming an effective chain entanglement. Under a high-voltage electric field, the jet It is easy to be pulled off, thus affecting the electrospinning effect

However, the small molecular solvents such as dimethylformamide DMF added by the inventive method are extremely volatile and have certain toxicity, which limits the application of sodium alginate nanofibers in biomedicine with higher safety requirements; Cui Li et al. The article "Performance and Electrospinning of Sodium Alginate / Polyvinyl Alcohol Solution" published on "Synthetic Fiber Industry" discloses a preparation method for preparing sodium alginate / polyvinyl alcohol composite micro-nano fibers. The mass fraction is 2% sodium alginate and 8% polyvinyl alcohol (PVA) with a mass fraction of 8% are mixed according to a certain volume ratio and then electrospun. The volume ratio of sodium alginate to PVA is (1 / 9) to (5 / 5) , a more stable composite fiber can be obtained, but the content of sodium alginate in this composite fiber is too low, which greatly reduces its application effect and limits its application in biomedicine; and the sodium alginate prepared by the above preparation method The output of nanofibers is low, which is only suitable for laboratory scientific research level and cannot meet the needs of large-scale industrial preparation

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