Dentin reactive monomer mixture and preparing method, polycarboxylic oligomer and preparing method, and dental composite resin bonding systems

A technology of reactive monomers and mixtures, applied in dental prosthesis, dentistry, dental preparations, etc., can solve problems such as increased water absorption, exacerbated nano-leakage, collagen exposure and degradation, and bonding failure

Active Publication Date: 2017-08-11
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to the micro-leakage caused by resin polymerization shrinkage, under the influence of various factors, it is difficult to completely remove the residual moisture at the bonding interface, and it is also difficult for the resin adhesive to completely penetrate and wrap the demineralized collagen fibers, so that in the mixed layer A layer of porous (about 20-100nm in diameter) and partially demineralized dentin structure that is not penetrated by resin is left between the non-demineralized dentin, forming a "adhesive defect zone" that is rich in water and partially exposed collagen fibers. Known as nanoleakage, the exposed collagen is susceptible to the combined action of factors such as temperature, stress, bacteria and their products, and demineralization that are exposed and activated by endogenous matrix metalloproteinases (MMPs), cysteine ​​cathepsins, etc. In addition, due to the presence of a large number of hydrophilic resin monomers, the water absorption rate of the cured resin is significantly increased, and it is easily degraded by the esterase in saliva, which intensifies the formation of nano-leakage, the exposure and degradation of collagen, eventually lead to bonding failure

Method used

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  • Dentin reactive monomer mixture and preparing method, polycarboxylic oligomer and preparing method, and dental composite resin bonding systems
  • Dentin reactive monomer mixture and preparing method, polycarboxylic oligomer and preparing method, and dental composite resin bonding systems
  • Dentin reactive monomer mixture and preparing method, polycarboxylic oligomer and preparing method, and dental composite resin bonding systems

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Add hexamethylene diisocyanate (HDI) and hydroxyethyl methacrylate (HEMA) at a ratio of 1:2 to a dry three-necked round-bottomed flask. The reaction system is stirred by a magnetic stirrer. The three-necked flask Connect the condensing pipe to the top, connect the dryer to the top of the condensing pipe, and connect the thermometer to the three-necked flask. The reaction system is heated at a constant temperature of 50°C, and the acetone solution of zinc naphthenate, which is a catalyst with a mass ratio of 0.5%, is added, and the di-n-butylamine hydrochloride method is used. Detect the isocyanate value of the system, and stop the reaction when the isocyanate value is close to zero. Bismethacryloxyethyl carbamate hexamethylene HEMA-HDI-HEMA was prepared. Refrigerate and store away from light.

Embodiment 2

[0100] The molar ratio of HDI to HEMA substance is 1:1. HDI was first added to the round bottom flask, HEMA was added drop by drop using a constant pressure dropping funnel, the rest of the reaction conditions were the same as in Example 1, and the reaction was stopped when the isocyanate value remained constant. Prepare monomethacryloyloxyethyl carbamate hexamethylene isocyanate HEMA-HDI, refrigerate, seal in a desiccator, and store in the dark.

Embodiment 3

[0102] The molar ratio of HDI to HEMA is 3:4; react and process according to the method described in Example 1 to obtain a photocurable dentin-reactive monomer mixture: HEMA-HDI-pHEMA is HEMA-HDI-HEMA, HEMA -HDI, a mixture of trace amounts of HDI, refrigerated, sealed in a desiccator, and stored away from light.

[0103] The obtained monomer mixture HEMA-TDI-pHEMA was characterized by attenuated total reflection infrared, and the obtained results are shown in Figure 1 ~ Figure 3 middle.

[0104] figure 1 It is the infrared spectrogram of the photocurable dentin reactive monomer mixture HEMA-TDI-pHEMA, which still retains the C=C characteristic absorption peak of HEMA at 1635 wavenumbers (compared with figure 2 ), the infrared absorption of isocyanate-NCO at 2233 wavenumbers is greatly reduced (compared to image 3 ), the primary hydroxyl absorption peak of HEMA disappears at the original 3440 wavenumber (compared to figure 2 ), and form a new absorption peak at wavenumb...

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PUM

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Abstract

The invention provides a dentin reactive monomer mixture and a preparing method, a polycarboxylic oligomer and a preparing method, and dental composite resin bonding systems, wherein the dentin reactive monomer mixture and the polycarboxylic oligomer are used for constructing the dental composite resin bonding systems. The invention further provides a single-component dental composite resin bonding systems and a double-component dental composite resin bonding system. The bonding systems overcome the defect that due to the fact that a large number of hydrophilic monomers are introduced into a traditional wet bonding technique, cured resin can be easily degraded by esterase in saliva as the water absorption rate is increased remarkably.

Description

technical field [0001] The invention relates to a dental restoration material, in particular to a dentin reactive monomer mixture and a preparation method, a polycarboxy oligomer and a preparation method, and a dental composite resin bonding system. Background technique [0002] With the increasing demand for aesthetics and the increasing awareness of tissue preservation, resin bonding restoration has replaced traditional amalgam filling and has become an important restoration method for tooth defects caused by caries and other diseases. The formation of the bond depends on the micromechanical fit force provided by the bonding resin after effective penetration and curing of the collagen fiber network exposed by the demineralized dentin. The traditional resin dentin bonding technology first needs to demineralize the dentin surface with phosphoric acid etchant or acidic bonding monomer, exposing the three-dimensional collagen fiber network structure with a thickness of several...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/08A61K6/033A61K6/027A61K6/00A61K6/838A61K6/884
CPCA61K6/62A61K6/74A61K6/76A61K6/831A61K6/838A61K6/884
Inventor 陈吉华常刚牛丽娜方明郑智明
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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