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Degradable polyurethane foam and application thereof

A polyurethane foam, polyurethane technology, applied in the field of polyurethane foam, can solve the problems of long cycle, easy introduction of impurities, loss of elasticity, etc.

Inactive Publication Date: 2017-10-24
SHAANXI RUISHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of this, those skilled in the art have carried out a large amount of research and development experiments, wherein, a patent application number is 201110382475.8 discloses a kind of novel chitosan hemostatic sponge and preparation method thereof, and it mainly adopts water-soluble chitosan, glycerin And poloxamer is obtained by high-speed stirring injection molding, quick freezing, demoulding and freeze-drying. The hemostatic sponge is elastic when dry, has high water absorption and high expansion, but the product will lose its elasticity when it meets water after use. , causing oppressive discomfort in the ear and nose cavity; another patent application number 101816801A discloses a biomedical foam, which provides a polyurethane foam whose soft segment uses hydrophilic diol and degradable polymer It is obtained by copolymerization of diol, and the soft segment is capped and purified by prepolymer before reacting with polyisocyanate with hard segment function. This polyurethane foam has a certain liquid absorption capacity, is elastic in a wet state, and can be quickly degraded. It is suitable for Clinical application, however, this preparation method adopts multi-step synthesis, and the preparation process of the soft segment is complicated, the cycle is long, and impurities are easily introduced, which is not conducive to industrial application

Method used

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  • Degradable polyurethane foam and application thereof
  • Degradable polyurethane foam and application thereof
  • Degradable polyurethane foam and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] For convenience of description, the polyurethane foam prepared in Example 1 is denoted as A.

[0071] The specific preparation method is as follows:

[0072] 1. Preparation of polylactide-caprolactone (PCLA)

[0073]Lactide and ε-caprolactone are ring-opened and polymerized at a molar ratio of 1:1, using butanediol (BDO) as an initiator and stannous octoate (0.001wt%) as a catalyst, and the initiator BDO is mixed with mono The weight ratio of BDO and caprolactone is 0.001%. After refining and removing water, add BDO and caprolactone into a three-necked or single-necked flask, fill with nitrogen for protection, put it into a heat-collecting magnetic stirrer or mechanically stir, and react in an oil bath at 130°C for 24 hours. After cooling, dichloromethane dissolved and absolute ethanol precipitated out. The purified product was dried in a vacuum oven at 40° C. for 24 h.

[0074] Characterized by infrared spectroscopy, nuclear magnetic (H-NMR), differential scanning c...

Embodiment 2

[0083] For convenience of description, the polyurethane foam prepared in Example 2 is denoted as B.

[0084] 1, prepare polylactide-caprolactone (PCLA) by the method for embodiment 1.

[0085] 2. Preparation of hydroxyl-terminated BDO-HDI-BDO (BHB) chain extender

[0086] Obtained by reacting excess butanediol BDO with hexamethylene diisocyanate (HDI). Take the 10-fold excess HDI of BDO that has been dried and dehydrated, and place it in a three-necked flask, protect it with nitrogen gas, add the liquid HDI dropwise into the three-necked flask under mechanical stirring, and react at 65°C for 5 hours. After the reaction, wash and filter with dry acetone. A white powder was obtained, which was dried in a vacuum oven at 50°C for 24 hours. Then carry out the characterization of DSC, IR and hydroxyl value. DSC shows that the obtained chain extender BHB has a purity of more than 95% and a melting point of about 98°C. The test result of the hydroxyl value is 308 mg / KOH, which is c...

Embodiment 3

[0094] For convenience of description, the polyurethane foam prepared in Example 3 is denoted as C.

[0095] The specific preparation method is as follows:

[0096] 1. Preparation of polylactide-glycolide prepolymer (PLGA)

[0097] The prepolymer was synthesized by ring-opening polymerization of propiolactone and glycolide at a molar ratio of 7:3, using 1,4-butanediol as the initiator and stannous octoate as the catalyst. Take a certain molar ratio of caprolactone and butanediol (0.001%) and add it to a 100ml three-necked flask, fill it with nitrogen for protection, put it into a collector type magnetic stirrer, heat it in an oil bath, stir it magnetically, and react at 140°C for 10h, then add a certain amount of A certain amount of glycolide monomer continued to react for 5 hours and then stopped the reaction. After cooling, the dichloromethane was dissolved and absolute ethanol was precipitated. The purified product was dried in a vacuum oven at 40° C. for 24 h.

[0098] ...

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Abstract

The invention relates to the technical field of biomaterials, in particular to degradable polyurethane foam and an application thereof. A preparation process of the degradable polyurethane foam is simple, shorter in cycle and capable of preventing introduction of impurities; an obtained product has better water absorption property and higher porosity, can be degraded rapidly and is suitable for clinical application. The polyurethane foam is prepared from polyurethane through dissolving in an organic solvent and freeze-drying, wherein polyurethane is prepared from oligomer polyol as a soft segment and polyisocyanates as a hard segment and a chain extender with an ontology one-step process, and the oligomer polyol is a mixture of hydrophilic polyol and degradable polyol. The degradable polyurethane foam in an embodiment of the invention is used for preparing hemostatic materials, wound dressing or ear and nose stuffing.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a degradable polyurethane foam and its application. Background technique [0002] As the pressure in people's life and work continues to increase, lesions in the ear cavity, nasal cavity and even body cavity often appear, such as nasal polyps, nasal cysts, epistaxis, otitis media, etc., which can be cured through clinical operations, but It can also cause bleeding and mucosal adhesions to a certain extent. [0003] At present, clinically, fillers are mainly used to fill the ear and nasal cavity to achieve the purpose of hemostasis. The initial hemostatic materials are gauze and cotton. Requires a second surgery for removal. [0004] In order to avoid the above adverse reactions, a hemostatic material is clinically needed, which not only has a certain mechanical strength, can serve the purpose of packing, but also has good hydrophilicity and suitable degradability. In view...

Claims

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Application Information

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IPC IPC(8): C08G18/73C08G18/66C08G18/42C08G18/48C08G18/44C08G18/32C08G18/12C08J9/28A61L15/26A61L15/42A61L15/64A61L24/00A61L24/04A61L26/00A61L31/06A61L31/14C08G101/00
CPCC08G18/73A61L15/26A61L15/425A61L15/64A61L24/0036A61L24/0042A61L24/046A61L26/0019A61L26/0085A61L26/009A61L31/06A61L31/146A61L31/148A61L2400/04C08G18/12C08G18/4018C08G18/428C08G18/44C08G18/4833C08G2101/00C08G2230/00C08J9/28C08J2201/0482C08J2207/10C08J2375/06C08J2375/08C08L75/04C08G18/3206
Inventor 荆晶晶冉永峰张锐利
Owner SHAANXI RUISHENG BIOTECH
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