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Modified natural macromolecular compound adsorbent and application thereof

An adsorbent and macromolecule technology, which is applied in the modified natural macromolecular compound adsorbent and its application field, can solve the problems of active ingredient loss, high energy consumption, and large solvent loss, etc., and achieve less active ingredient loss and stable chemical structure , high adsorption selectivity

Inactive Publication Date: 2002-11-20
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has large solvent loss and high energy consumption, and has strict requirements on production equipment.
Another example is the oral and injection dosage forms of some traditional Chinese medicines. In order to ensure the stability and safety of the preparations, the tannin must be completely removed. In the past, lead salts, ethanol or gelatin precipitation methods were mostly used (Chinese Medicine Bulletin, 1986, 11(9): 542), not only the loss of active ingredients is serious, but also easy to produce heavy metal or gelatin residual pollution; formaldehyde cross-linked gelatin resin adsorption method can well overcome the above shortcomings (Chinese herbal medicine, 1991, 22 (11): 489), but it also brings new question
These sorbents have very poor mechanical strength, cannot be handled and reused in columns, and are also chemically unstable
Other general-purpose adsorption resins cannot obtain satisfactory results due to poor selectivity of adsorbing phenolic natural products due to the hydrophobicity of the skeleton and the non-specificity of functional groups.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Dissolve gelatin in water to make an 8% (w / w) aqueous solution; dissolve polyvinyl alcohol in water to make a 15% (w / w) aqueous solution. Then above-mentioned two kinds of solutions are mixed together by the volume ratio of gelatin:polyvinyl alcohol=3:2 and stir evenly. Then use 5% hydrochloric acid to adjust the pH of the above mixed aqueous solution to 2-4, and add 50% glutaraldehyde aqueous solution with a solution weight of 2.5% (v / w). Dissolve 0.2% (w / w) nonionic surfactant Span-80 in liquid wax, then add the above mixed aqueous solution (its volume is 1 / 2 of the organic phase) under stirring, and heat up to 70°C for reaction 3 hours or more. After post-treatments such as filtration and washing, the required spherical cross-linked polymer adsorption resin is prepared, and the particle size is 0.2-1.0 mm.

Embodiment 2

[0012] Dissolve gelatin in water to make a 15% (w / w) aqueous solution; dissolve polyvinyl alcohol in water to make an 8% (w / w) aqueous solution. Then above-mentioned two kinds of solutions are mixed together by the volume ratio of gelatin:polyvinyl alcohol=1:8 and stir evenly. Then use 5% hydrochloric acid to adjust the pH of the above mixed aqueous solution to 2-4, and add 50% glutaraldehyde aqueous solution with a solution weight of 12% (v / w). Dissolve 0.6% (w / w) of the non-ionic surface active agent Tuwen-60 in o-chlorodiphenyl, then add the above-mentioned mixed aqueous solution (its volume is 1 / 4 of the organic phase) under stirring, and heat up to 50 °C for more than 3 hours. After post-treatments such as filtration and washing, the required spherical cross-linked polymer adsorption resin is prepared, and the particle size is 0.2-1.0 mm.

Embodiment 3

[0014] Crush 20 grams of ginkgo leaves (nursery leaves produced in East China) and heat-extract them with ethanol aqueous solution. After recovering ethanol from the extract, dilute it with water to 40-80 ml, and filter to obtain a clear aqueous solution. The aqueous solution that obtains is passed into the resin column (15mm of post diameter, dress 20 milliliters of resins) that the cross-linked polymer adsorption resin that is prepared in embodiment 1 is housed, wherein flavonoids composition is effectively adsorbed in the resin, and then After washing with 20-100 ml of deionized water and desorbing with 40 ml of 70% ethanol, the flow rate of adsorption, washing, and desorption is 0.5 times the resin bed volume / hour, and the desorption solution is concentrated under reduced pressure, dried, and pulverized to obtain powdered extract The product (A) is analyzed by high-performance liquid chromatography, and the content of flavonoid glycosides in A is more than 60%, the content ...

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Abstract

A solid adsorbent of modified natural macromolecular compound is prepared through mixing gelatin (8-15 w%) with aqueous solution of polyvinyl alcohol in volume ratio of (1-3) : (8-2), regulating pH value to 2-4, quantitatively adding glutaraldehyde, mixing with organic solvent in which non-ionic surfactant is dissolved, heating, reaction, filter and washing to obtain the spherical (0.2-1 mm) adsorbent of gelatin-polyvinyl alcohol polymer. Said adsorbent can be used to extract the substance containing flavone glycoside (more than 59%) and the substance containing terpene lactone (more than 35%) from gingko leaves, and to remove tannin from Chinese medicine. Said adsorbent features high strength and stability, low cost and reuse.

Description

technical field [0001] The technical solution claimed in the present invention belongs to the organic material solid adsorbent and its application in the selective adsorption separation of liquid. Background technique [0002] Gelatin is a natural amphoteric macromolecule of weak acid and weak base. It has good hydrophilic properties and biocompatibility, and can be used in medical, pharmaceutical and other fields, such as cross-linked copolymerization of gelatin with polyacrylic acid, polylactic acid, etc. It can be used as drug slow-release carrier and tissue healing material, etc. Heat-denatured gelatin adsorbent can be used to enrich copper from seawater or industrial wastewater. South Korea has reported that gelatin and polyvinyl alcohol can be reacted with aldehydes to form a film-shaped crosslink Polymers, used as artificial skin. Natural polyphenolic compounds are ubiquitous in plants. Some of these components in Chinese herbal medicines have obvious pharmacological...

Claims

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Application Information

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IPC IPC(8): B01J20/24B01J20/26
Inventor 许名成史作清施荣富路延龄何炳林
Owner NANKAI UNIV
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