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A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization

A temperature-responsive, precipitation polymerization technology, applied in chemical instruments and methods, organic compound/hydride/coordination complex catalysts, physical/chemical process catalysts, etc., can solve troublesome operations, complicated devices, and difficulty in preparing nano problems such as microspheres, to achieve high conversion efficiency, improved dispersion, and reasonable methods

Active Publication Date: 2020-12-04
SUZHOU CHIEN SHIUNG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After the product chain grows to a certain length, it will be insoluble in the solvent and precipitate out separately. The surface of the product obtained in this way is pure, and it only takes 1 h~2 h in a short time and has a uniform particle size, but the problem is that it is only suitable for temperature-sensitive monomers. , it is difficult to apply to the more common hydrophilic monomers to prepare nano-microspheres, and the device is complicated to operate, and the amount of solvent evaporation must be controlled during the reaction to ensure the stability of the reaction system and good dispersion of microspheres

Method used

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  • A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization
  • A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization
  • A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization

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Embodiment 1

[0034] A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization, comprising the following steps:

[0035] 1) Preparation of nano-microspheres:

[0036] Add 0.0303 g of N-methylolacrylamide (NHMA), 0.113 g of N-isopropylacrylamide (NIPAM), 0.022 g of N,N-methylenebisacrylamide into a 50 ml round bottom flask (MBA), 0.0044 g of azobisisobutyronitrile (AIBN) and 10 ml of acetonitrile solution, after the ultrasonic dispersion is uniform, put in the magnet, install the oil bath device, turn on the magnetic stirring, and heat the magnetic stirring at a stirring speed of 200 r / min, the temperature was raised to 85 °C to start the reaction, and the reaction was completed under constant temperature reflux for 2 h; the white emulsion was poured out, centrifuged at 4000 r / min for 10 min in a high-speed centrifuge, the upper layer solution was discarded, and the precipitate was washed with absolute ethanol Then carry out ultrasonic dispers...

Embodiment 2

[0042] A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization, comprising the following steps:

[0043] 1) Preparation of nano-microspheres:

[0044] Add 0.202 g of N-methylolacrylamide (NHMA), 0.417 g of N-isopropylacrylamide (NIPAM), 0.264 g of N,N-methylenebisacrylamide into a 50 ml round bottom flask (MBA), 0.0220 g of azobisisobutyronitrile (AIBN) and 30 ml of acetonitrile solution, after the ultrasonic dispersion is uniform, put in the magnet, install the oil bath device, turn on the magnetic stirring, and heat the magnetic stirring at a stirring speed of 600 r / min, the temperature was raised to 90 °C to start the reaction, and the reaction was completed under constant temperature reflux for 2 h; the white emulsion was poured out and centrifuged at a speed of 4000 r / min for 10 min in a high-speed centrifuge, the upper layer solution was discarded, and the precipitate was washed with absolute ethanol Then carry out ultra...

Embodiment 3

[0050] A method for preparing temperature-responsive iron-based nanozymes by reflux precipitation polymerization, comprising the following steps:

[0051] 1) Preparation of nano-microspheres:

[0052] Add 0.1010 g of N-methylolacrylamide (NHMA), 0.3396 g of N-isopropylacrylamide (NIPAM), 0.1321 g of N,N-methylenebisacrylamide into a 50 ml round bottom flask (MBA), 0.0110 g of azobisisobutyronitrile (AIBN) and 20 ml of acetonitrile solution, after the ultrasonic dispersion is uniform, put in the magnet, install the oil bath device, turn on the magnetic stirring, and heat the magnetic stirring at a stirring speed of 300 r / min, the temperature was raised to 90 °C to start the reaction, and the reaction was completed under constant temperature reflux for 2 h; the white emulsion was poured out and centrifuged at a speed of 4000 r / min for 10 min in a high-speed centrifuge, the upper layer solution was discarded, and the precipitate was washed with absolute ethanol Then carry out ul...

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Abstract

A method for preparing thermo-responsive iron-based nano-enzyme by reflux precipitation polymerization is disclosed. Isopropyl acrylamide or vinyl caprolactam and hydroxymethyl acrylamide are used asthe main monomers, reflux precipitation polymerization is adopted, and a simple reflux condensing tube is used to replace a complex distillation device and a solvent collection device. Then, a solventis refluxing in the system, magnetic stirring is also added to change dispersity. The method of the invention has higher efficiency, is simpler to operate and is more suitable for preparation of nanospheres. Then, phosphorus pentoxide is used for phosphate esterification of the composite microspheres, followed by chelation with Fe<2+> ions. Finally, the nano-catalysis microspheres with peroxidaseactivity are formed. The reaction is simple to operate, and the particles obtained have small and uniform particle size, large specific surface area and high catalytic activity.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to a method for preparing a polymer nanozyme, in particular to a method for preparing a temperature-responsive iron-based nanozyme by reflux precipitation polymerization. Background technique [0002] Nanozymes are a class of nanomaterials with catalytic activity similar to natural enzymes. Since 2007, more than 50 different nanozymes have been discovered and used in many fields such as biology, medicine, agriculture, environmental governance, and national defense security. Research. In recent years, the application research of nanozyme has developed from in vitro detection to in vivo treatment, showing its important influence on modern biomedical technology and broad application potential. [0003] Catalase can decompose hydrogen peroxide into water and oxygen. Many major diseases in the human body are related to the imbalance of redox reactions in the body. Relevant schol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/54C08F222/38C08F8/40C08F8/42B01J31/22
Inventor 王杨常柏松顾准刘尚莲朱少晖周帅康
Owner SUZHOU CHIEN SHIUNG INST OF TECH
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