Preparation method for PVDF/GBT composite bone scaffold

A bone scaffold and composite powder technology, applied in medical science, tissue regeneration, prostheses, etc., can solve the problem of poor interface bonding between nanoparticles and polymer matrix, difficulty in strengthening piezoelectric and mechanical properties of materials, and piezoelectricity of composite materials. Performance can not be enhanced and other problems, to achieve the effect of improving electromechanical coupling efficiency, enhancing interface compatibility, and enhancing interface bonding

Inactive Publication Date: 2019-10-11
JIANGXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The improvement of the above properties is based on the nano-BaTiO 3 Based on the good dispersion and interfacial bonding of the particles in PVDF, however, the nano-BaTiO 3 The particles have high surface energy and lack of functional sites on the surface, which makes them easy to agglomerate in PVDF. On the one hand, this will lead to the weakening or even failure of the ability of nanoparticles to induce PVDF to produce β-crystals, and the piezoelectri...

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  • Preparation method for PVDF/GBT composite bone scaffold

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Embodiment 1

[0047] (1) 2 g of dopamine hydrochloride powder was weighed with an electronic balance, and added to 10 mM Tris-HCL buffer solution to prepare 1 L of 2.0 mg / mL dopamine solution.

[0048] (2) Use an electronic balance to weigh 5g of BaTiO with a particle size of 200nm 3 Add the powder into the above-mentioned dopamine solution, and disperse evenly through mechanical stirring and ultrasound. The main process parameters are: dopamine polymerization reaction time is 5h, mechanical stirring speed is 80r / min; reaction temperature is 60°C, pH is 7, and then The obtained suspension was filtered and washed with deionized water to remove unreacted dopamine monomer on the surface; vacuum-dried at 60° C. for 12 hours to obtain polydopamine-modified barium titanate powder.

[0049] (3) Weigh 1 g of DBT powder with an electronic balance, add it into a three-necked flask filled with anhydrous ethanol solution, and realize its pre-dispersion by mechanical stirring and ultrasonic dispersion. ...

Embodiment 2

[0056] (1) 2 g of dopamine hydrochloride powder was weighed by an electronic balance, and added to 10 mM Tris-HCL buffer solution to prepare a 2.0 mg / mL dopamine solution.

[0057] (2) Weigh 5g of BaTiO with a particle size of 400nm using an electronic balance 3 Add the powder into the above-mentioned dopamine solution, and disperse evenly through mechanical stirring and ultrasound. The main process parameters are: the dopamine polymerization reaction time is 5h, the mechanical stirring speed is 80r / min; The suspension was filtered and washed with deionized water to remove unreacted dopamine monomer on the surface; vacuum-dried at 60° C. for 12 hours to obtain polydopamine-modified barium titanate powder.

[0058] (3) Weigh 2 g of DBT powder with an electronic balance, add it into a three-necked flask filled with anhydrous ethanol solution, and realize its pre-dispersion by mechanical stirring and ultrasonic dispersion.

[0059] (4) Use an electronic balance to weigh 8g of PV...

Embodiment 3

[0065] (1) 2 g of dopamine hydrochloride powder was weighed by an electronic balance, and added to 10 mM Tris-HCL buffer solution to prepare a 2.0 mg / mL dopamine solution.

[0066] (2) Utilize the electronic balance to weigh 5g of powders with a particle diameter of 400nm, join in the above-mentioned dopamine solution, and disperse evenly through mechanical stirring and ultrasonic waves. The main process parameters are: the dopamine polymerization reaction time is 5h, and the mechanical stirring speed is 80r / min; the reaction temperature is 50°C, the pH is 9, and then the obtained suspension is filtered and washed with deionized water to remove the unreacted dopamine monomer on the surface; vacuum-dried at 60°C for 12 hours to obtain polydopamine-modified titanium Barium Oxide powder.

[0067] (3) Weigh 0.5 g of DBT powder with an electronic balance, add it into a three-necked flask filled with anhydrous ethanol solution, and realize its pre-dispersion by mechanical stirring ...

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Abstract

The invention discloses a preparation method for a PVDF/GBT composite bone scaffold. The method comprises the steps that by using an in-situ polymerization method, DBT powder of a core-shell structurewith BaTiO3 coated with polydopamine is obtained on the surface of the BaTiO3; the DBT powder and PVDF powder are subjected to liquid mixing, ultrasonic treatment, stirring, dispersion, drying and grinding to obtain PVDF/DBT composite powder; the PVDF/DBT composite powder is subjected to selective laser sintering to obtain the PVDF/GBT composite bone scaffold. The BaTiO3 nano-particles which areuniformly dispersed have high performance of interface bonding with PVDF, good piezoelectric, mechanical and biological properties are given to the scaffold, an endogenous electrical microenvironmentgenerated by the scaffold can generate electrical stimulation to bone cells, and therefore, adhesion, proliferation and differentiation of the bone cells on the bone scaffold are promoted.

Description

technical field [0001] The invention relates to a composite bone support, in particular to a method for preparing a PVDF / DBT composite bone support, and belongs to the technical field of artificial bone support preparation. Background technique [0002] At present, artificial bone scaffolds have prominent problems such as low osteoinductive activity, slow bone regeneration and osseointegration due to slow cell response, poor osteogenic differentiation ability, and insufficient nutrition. Bone itself has piezoelectricity. Appropriate electrical stimulation can increase the concentration of free calcium ions in the cell fluid, promote the directional deposition of calcium and phosphorus minerals, regulate the expression of bone-related genes, improve the activity of alkaline phosphatase and local blood supply, etc. This accelerates bone regeneration and repair. Biopiezoelectric materials can deform and induce electric charge under exogenous mechanical stress, and biomimetic c...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/50
CPCA61L27/446A61L27/50A61L2430/02C08L27/16
Inventor 帅词俊戚方伟彭淑平杨友文
Owner JIANGXI UNIV OF SCI & TECH
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