Technology for regulating and controlling Jak-Stat pathway to differentiate, dedifferentiate and rejuvenate cells, and application of technology

A cell differentiation and de-differentiation technology, applied in animal cells, cell culture active agents, genetically modified cells, etc., can solve the problems of tumorigenesis, genetic variation, unfavorable clinical application, etc.
CN110423719APending Publication Date: 2019-11-08YUNNAN JICI INSITUTE FOR REGENERATIVE MEDICINE CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
YUNNAN JICI INSITUTE FOR REGENERATIVE MEDICINE CO LTD
Publication Date
2019-11-08

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Abstract

The present invention belongs to the technical field of cell biology and particularly relates to a technology for regulating and controlling a Jak-Stat pathway to differentiate, dedifferentiate and rejuvenate cells, and an application of the technology. Rejuvenated cell products and / or cell products of different lineage types are obtained by small molecule compound combination, cytokine combination or recombinant protein combination, a gene editing technology and a transgenic technology to quantitatively and / or regularly regulate and control gene or protein targets of the Jak-Stat signaling pathways in cells. The provided technology for regulating and controlling the Jak-Stat signal pathway, and the product / derivatives of the cell product can be used for re-programming cells, tissues, organs and organisms, construct tissue engineering materials, repair damages of tissues and organs of mammals and the aged and degenerated tissues and organs, delay or reverse aging processes of the cells, tissues, organs and organisms, and can be used for immunoregulation of the cells, tissues, organs and organisms.
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Description

technical field

[0001] The invention belongs to the technical field of cell biology, and relates to a technique for regulating the Jak-Stat pathway to make cells differentiate, dedifferentiate and rejuvenate and its application, especially to regulate the JAK-STAT signal pathway to regulate cell differentiation, dedifferentiation and transdifferentiation , rejuvenation, aging, apoptosis and methods for prolonging the life of the body and the preparation and application of cell products. Background technique

[0002] Stem cells are considered the "holy grail" of regenerative medicine and anti-aging. When an individual begins to age, the stem cells in the body will also age, leading to malignant transformation or degeneration of multiple organs including bone, cartilage, heart, muscle, brain, skin, pancreas, liver, kidney, and gastrointestinal tract. Improper immune system function is also associated with aging. In fact, chronic inflammation of tissues and organs is the caus...

Claims

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