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Biomaterial devices and topical compositions for guided tissue regeneration

A technology for guiding tissue regeneration, mixture, applied in the field of biomaterial devices, which can solve the problems of limited stability, biodegradability and tensile strength, insufficient biocompatibility, etc.

Pending Publication Date: 2020-04-17
MARINE ESSENCE BIOSCI CORP OF USA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan formulations and materials suffer from a number of disadvantages including limited stability, biodegradability and tensile strength
Materials such as modified chitosan and synthetic composites have been tested for many of the same uses of chitosan, however many of these materials have similar disadvantages including insufficient biocompatibility

Method used

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  • Biomaterial devices and topical compositions for guided tissue regeneration
  • Biomaterial devices and topical compositions for guided tissue regeneration
  • Biomaterial devices and topical compositions for guided tissue regeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Example 1. MCT-Chitosan Complex: Preparation, Data and Applications

[0107] Pharmaceutical grade chitosan (via 1 Degree of deacetylation calculated by H NMR 92%; average molecular weight calculated by specific viscometry 185 kDa) was purchased from Sigma Aldrich (St. Louis, MO, USA). The degree of deacetylation and average molecular weight distribution can be controlled in the production of MCT-chitosan complexes to provide chitosan with higher or lower degrees of deacetylation and / or higher or lower average molecular weight.

[0108] Isolation of variable collagen tissue (MCT) from the marine invertebrate Echinodermata. Adult specimens of sea urchins, starfish and sea cucumbers were collected and immediately dissected by divers in places such as China, Tahiti and Japan. Specimens of sea urchin periostial membrane, starfish counterpart arm wall and sea cucumber whole body wall were collected and stored at -20°C for subsequent Ferrario C., Leggio L., Leone R., Di Bene...

Embodiment 2

[0125] Example 2. MCT-chitosan complex 3D-sponge for GTR, wound healing and tissue engineering

[0126] Chitosan (CHT) has been reported to be biocompatible and bioabsorbable. In particular, CHT is considered a good wound healing accelerator. On the other hand, collagen (MCT) is one of the most widely used matrix biomaterials in tissue engineering. Highly porous MCT single 3D sponges have been used to support the growth of many types of tissues in vitro. Hybrid 3D-sponge biomaterials were prepared by mixing CHT (isolated from sea cucumber samples) and MCT at different mass ratios, applying a previously developed method involving solvent casting and freeze-drying. The MCT / CHT hybrid 3D-sponge was characterized according to its water absorption capacity, mechanical properties, thermal behavior (TGA) and morphology (SEM). Compared with single 3D sponges, hybrid 3D sponges showed improved stability, larger porosity, increased thermal stability and mechanical properties, and hig...

Embodiment 3

[0146] Example 3. Electrospun MCT-chitosan composite nanofibers as biocompatible sponges for cell proliferation in wound healing and tissue engineering applications

[0147]Electrospun nanofibers (ESNFs) were prepared from MCT-chitosan composites. Polyvinyl alcohol (PVA) was used as adjuvant. MCT-chitosan / PVA mixed solutions with different volume ratios (100:0, 80:20, 60:40, 40:60, 20:80 and 0:100) were prepared and adjusted to a viscosity suitable for electrospinning It is similar to the conductivity aspect. The morphology of ESNFs was examined using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Studies are used to characterize the chemical composition and thermal properties of nanofibers (NFs). The ability of NF to support fibroblast proliferation was investigated in vitro using an optimized MCT-chitosan / PVA solution. The results showed that the MCT-chitosan-based ESNF was very suitable fo...

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Abstract

Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT), wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma / chloasma.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Nonprovisional Patent Application No. 16 / 123,942, filed September 6, 2018, which nonprovisional application is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to biomaterial devices for guided tissue regeneration (GTR). More specifically, the present invention relates to tissue sponges, wound dressings, cosmeceutical and other devices and topical compositions comprising variable collagen tissue (MCT) for achieving GTR. More specifically, the present invention relates to such a device comprising a complex of MCT and chitosan biopolymer (CHT) for achieving GTR. The present invention also relates to the treatment of burns, wounds, ulcers and other lesions and related skin diseases by applying MCT alone or as a complex in biomaterial devices to promote GTR. The present invention also relates to the treatment of skin abnormali...

Claims

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Application Information

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IPC IPC(8): A61K35/616A61K35/618A61K35/655A61P17/02A61P17/00A61K31/722
CPCA61K35/616A61K35/618A61K35/655A61K31/722A61K9/0014A61P17/02A61P17/00A61K2300/00A61L27/44A61L27/3604A61L27/52A61L27/56A61L15/28A61L15/325A61L15/40A61L15/425A61M35/003A61K47/42A61K47/36A61P41/00A61K8/65A61K8/736A61Q19/02A61L2300/236A61L2300/232
Inventor 邱丹尼塞尔吉奥·马德里加尔·卡巴洛
Owner MARINE ESSENCE BIOSCI CORP OF USA
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