Biomaterial devices and topical compositions for guided tissue regeneration

A technology for guiding tissue regeneration, mixture, applied in the field of biomaterial devices, which can solve the problems of limited stability, biodegradability and tensile strength, insufficient biocompatibility, etc.
CN111012803APending Publication Date: 2020-04-17MARINE ESSENCE BIOSCI CORP OF USA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MARINE ESSENCE BIOSCI CORP OF USA
Publication Date
2020-04-17

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Abstract

Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT), wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma / chloasma.
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Description

[0001] Cross References to Related Applications

[0002] This application claims priority to U.S. Nonprovisional Patent Application No. 16 / 123,942, filed September 6, 2018, which nonprovisional application is hereby incorporated by reference in its entirety. technical field

[0003] The present invention relates to biomaterial devices for guided tissue regeneration (GTR). More specifically, the present invention relates to tissue sponges, wound dressings, cosmeceutical and other devices and topical compositions comprising variable collagen tissue (MCT) for achieving GTR. More specifically, the present invention relates to such a device comprising a complex of MCT and chitosan biopolymer (CHT) for achieving GTR. The present invention also relates to the treatment of burns, wounds, ulcers and other lesions and related skin diseases by applying MCT alone or as a complex in biomaterial devices to promote GTR. The present invention also relates to the treatment of skin abnormali...

Claims

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