A preparation method of ultra-uniform spherical gold nanoparticles with different particle sizes

A nano-gold particle, ultra-uniform technology, applied in nanotechnology, nanotechnology, metal processing equipment, etc., can solve problems such as irregular shape, uneven particle size of nano-gold particles, and difficult process control.

Active Publication Date: 2021-11-16
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current technology uses a single reducing agent to prepare gold nanoparticles at one time. The process is difficult to control, and the prepared gold nanoparticles are not uniform in size and irregular in shape; and the prepared gold nanoparticles limit their applications in medical testing, chemical sensing, and environmental protection. Applications in monitoring and other fields

Method used

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  • A preparation method of ultra-uniform spherical gold nanoparticles with different particle sizes
  • A preparation method of ultra-uniform spherical gold nanoparticles with different particle sizes
  • A preparation method of ultra-uniform spherical gold nanoparticles with different particle sizes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Solution preparation and seed preparation

[0032] 1. Solution preparation

[0033] All containers were treated with aqua regia, cleaned with ultrapure water, and dried for later use. Accurately weigh 1g of chloroauric acid powder and dissolve it in 50ml of ultrapure water to prepare chloroauric acid with a final concentration of 2%, store it in a brown reagent bottle at 4°C for later use; accurately weigh 0.539g of potassium borohydride and dissolve it in 100ml of ultrapure In water, prepare a solution with a concentration of 0.1mol / L, ready for immediate use; accurately weigh 1.18g of trisodium citrate dihydrate and dissolve it in 100ml of ultrapure water, prepare a solution with a concentration of 0.04mol / L, and use 0.22μm Membrane filtration, set aside at 4°C; accurately weigh 11.68g of α-cyclodextrin and dissolve in 100ml of ultrapure water to prepare a solution with a concentration of 0.12mol / L, filter through a 0.22μm filter membrane, set aside at 4°C...

Embodiment 2

[0037] Embodiment 2: Preparation of nano gold particles

[0038] 1. Reagents

[0039] 2% chloroauric acid, 0.2mol / L ascorbic acid solution, 0.12mol / L α-cyclodextrin solution, 1mmol / L 1,2-bis(N-hexadecyl-N,N-dimethylammonium bromide )-ethane solution, the preparation method sees embodiment 1;

[0040] 2. Preparation method

[0041]Place a 100ml round bottom flask in an ice bath environment, add 1ml of seeds, and dilute to 26mL with ultrapure water, then add 0.18ml of ascorbic acid as a reducing agent, add 600μL of Gemini surfactant and 3.75ml of α-cyclodextrin As a protectant, then give it a quick stir to coat. Take 0.1ml of chloroauric acid, slowly drop it into the round bottom flask, it can be observed that the color turns into wine red, continue to stir for 30min, set aside.

[0042] An appropriate amount of the above-mentioned gold nanoparticle solution was taken for ultraviolet-visible spectroscopy (UV-Vis) analysis and transmission electron microscope (TEM) analysis. ...

Embodiment 3

[0043] Embodiment 3: Preparation of nano gold particles

[0044] 1. Reagents

[0045] 2% chloroauric acid, 0.2mol / L ascorbic acid solution, 0.12mol / L α-cyclodextrin solution, 1mmol / L 1,2-bis(N-hexadecyl-N,N-dimethylammonium bromide )-ethane solution, the preparation method sees embodiment 1;

[0046] 2. Preparation method

[0047] Place a 100ml round bottom flask in an ice bath environment, add 1ml of seeds, and dilute to 26mL with ultrapure water, then add 0.225ml of ascorbic acid as a reducing agent, add 600μL of Gemini surfactant and 3.75ml of α-cyclodextrin As a protectant, then give it a quick stir to coat. Take 0.15ml of chloroauric acid, slowly drop it into the round bottom flask, it can be observed that the color changes from wine red to purple, continue to stir for 30min, set aside.

[0048] An appropriate amount of the above-mentioned gold nanoparticle solution was taken for ultraviolet-visible spectroscopy (UV-Vis) analysis and transmission electron microscope (...

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Abstract

The invention relates to the technical field of nano-gold particles, and discloses a method for preparing super-uniform spherical gold nanoparticles with different particle sizes. The present invention first prepared 15nm nano-gold particles as seeds by the potassium borohydride method, adopted ascorbic acid as a reducing agent, Gemini surfactant and α-cyclodextrin as a protective agent through the seed growth method, added chloroauric acid and reduced The consumption of agent, further prepares the spherical gold nano-particle of the particle diameter of 40-200nm, smooth surface, particle diameter.

Description

technical field [0001] The invention relates to the technical field of nano-gold particles, in particular to a method for preparing super-uniform spherical gold nanoparticles with different particle sizes. Background technique [0002] Nano-gold particles are undetermined, uniform, and single-dispersed gold particle suspensions formed after gold salts are reduced to gold elements. Gold nanoparticles play an irreplaceable role in optics, catalysis, electronics, immunodiagnosis, biosensors, bioimaging, and drug delivery due to their good electrical conductivity, stability, biocompatibility, and surface optical properties. In-depth research on the combination of biotechnology and nanotechnology has become the frontier and hot spot of biomedical research. Nanogold labeling has developed into an important immune labeling technology. Nanogold immunoassays have been used in many fields such as drug detection and biomedicine. Great development. [0003] At present, the preparation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB22F9/24B82Y30/00B82Y40/00B22F1/054B22F1/065
Inventor 孟赓朱文壮
Owner CHINA AGRI UNIV
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