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Fluorine-containing graphene quantum dot, preparation and application thereof as photodynamic therapy photosensitizer

A technology of graphene quantum dots and graphene, applied in photodynamic therapy, graphene, medical preparations containing active ingredients, etc., can solve problems such as unclear fluorine content, complicated synthesis process, and slightly larger size, and achieve Stable optical performance, easy surface modification, and uniform shape

Active Publication Date: 2020-08-11
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Another reported fluorinated graphene quantum dots (Sun, Han-Jun, et al. "Synthesis of Fluorinated and Nonfluorinated Graphene Quantum Dots through a New Top-Down Strategy for Long-Time Cellular Imaging." Chem.Eur.J.2015, 21,3791-3797) is also synthesized by microwave-assisted hydrothermal method using fluorinated graphite as raw material. Although its fluorine content is as low as 1.2%, its size is slightly larger (3.0nm-10.0nm), and the synthesis process is relatively complex
In addition, the fluorinated graphene quantum dots reported above have not been used in the study of PDT photosensitizers
[0007] In addition, the fluorinated graphene quantum dots reported in the existing Chinese invention patent (CN201610935474.4), due to different raw materials and synthesis methods, the size of the synthesized fluorinated graphene quantum dots is not very uniform, the fluorine content is not clear, and There is also no research on photosensitizers for PDT

Method used

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  • Fluorine-containing graphene quantum dot, preparation and application thereof as photodynamic therapy photosensitizer
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Embodiment 1

[0036] A preparation method for fluorine-containing graphene quantum dots that can be used for photodynamic therapy, specifically comprising the following steps:

[0037] 1) Soak fluorinated graphite in 30% sodium hydroxide solution, disperse with ultrasonic stirring for 12 hours to fully peel off, then filter and dry;

[0038] 2) The fluorinated graphite treated in step (1) is prepared by the Hummers method to obtain fluorine-containing graphene; the fluorine content is 6%-8%, the oxygen content is 6%-8%, and the carbon content is 80%-90% %, it can be seen that it is a two-dimensional nano film (see Figure 4 );

[0039] 3) Weigh 60 mg of the above-mentioned oxidized fluorine-containing graphene, dissolve it in 60 ml of ultrapure water, and process it with an ultrasonic power of 500 watts, then add 60 ml of hydrogen peroxide to fully dissolve;

[0040] 4) Add 400 microliters of potassium hydroxide solution with a concentration of 1 mole per liter to the above solution, then...

Embodiment 2

[0060] A preparation method for fluorine-containing graphene quantum dots, specifically comprising the following steps:

[0061] 1) Soak fluorinated graphite in 40% sodium hydroxide solution, disperse with ultrasonic stirring for 12 hours to fully peel off, then filter and dry;

[0062] 2) The fluorinated graphite treated in step (1) is prepared by the Hummers method to obtain fluorine-containing graphene; the fluorine content is 6%-8%, the oxygen content is 6%-8%, and the carbon content is 80%-90% %, it can be seen that it is a two-dimensional nano film;

[0063] 3) Weigh 60 mg of the above-mentioned graphene oxide, dissolve it in 60 ml of ultrapure water, and process it with an ultrasonic power of 800 watts, then add a mixture of 20 grams of concentrated sulfuric acid and concentrated nitric acid to fully dissolve;

[0064] 4) Add 600 microliters of potassium hydroxide solution with a concentration of 1 mole per liter to the above solution, then transfer the above solution ...

Embodiment 3

[0067] A preparation method for fluorine-containing graphene quantum dots, specifically comprising the following steps:

[0068] 1) Soak fluorinated graphite in 30% sodium hydroxide solution, disperse with ultrasonic stirring for 12 hours to fully peel off, then filter and dry;

[0069]2) The fluorinated graphite treated in step (1) is prepared by the Hummers method to obtain fluorine-containing graphene; the fluorine content is 6%-8%, the oxygen content is 6%-8%, and the carbon content is 80%-90% %, it can be seen that it is a two-dimensional nano film;

[0070] 3) Weigh 60 mg of the above-mentioned oxidized fluorine-containing graphene, dissolve it in 60 ml of ultrapure water, and process it with an ultrasonic power of 600 watts, then add 60 ml of hydrogen peroxide to fully dissolve;

[0071] 4) Add 400 microliters, 1 mole per liter of sodium hydroxide solution to the above solution, then transfer the above solution to a round bottom flask, and reflux for 5 hours in an oil ...

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Abstract

The invention discloses a fluorine-containing graphene quantum dot, a preparation method and application thereof as a photodynamic therapy photosensitizer, and belongs to the field of biomedical materials. The average thickness of the prepared fluorine-containing graphene quantum dot is 1.0-3.0 nanometers, the size is 2.0-3.0 nanometers, the fluorine content is 1%-2%, the oxygen content is 20%-30%, and the carbon content is 60%-70%. The fluorine-containing graphene quantum dot is smaller in size, uniform in morphology, stable in structure, high in singlet oxygen yield under visible light irradiation, extremely low in cytotoxicity, good in water solubility and more excellent in biocompatibility and is an ideal photosensitizer for photodynamic therapy and is suitable for the early treatmentprocess of esophagus cancer, skin cancer, lung cancer and the like and has a wide application prospect.

Description

technical field [0001] The invention relates to a fluorine-containing graphene quantum dot, its preparation and its application as a photosensitizer for photodynamic therapy, belonging to the technical field of nano medical materials. Background technique [0002] Graphene quantum dots represent a new class of carbon quantum dots with unique properties, a zero-dimensional material with features derived from graphene and carbon dots, which can be regarded as small pieces of graphene with a size less than 10 nanometers, and will become a traditional semiconductor Potential replacements for quantum dots and organic dyes in life sciences. Graphene quantum dots have some superior properties, such as better biocompatibility, excellent anti-photobleaching ability, good fluorescence properties, and easy surface modification, making them widely used in biomarkers, bioimaging, and photodynamic therapy. applications have attracted much attention. [0003] Photodynamic therapy (PDT) i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y30/00B82Y20/00A61K41/00A61P35/00C01B32/198C01B32/19
CPCA61K41/0057A61P35/00B82Y20/00B82Y30/00C09K11/65C01B32/19C01B32/198
Inventor 毕红李真真
Owner ANHUI UNIVERSITY
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