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Osteoinductive regenerative film and its preparation method and application

A regenerative membrane and osteoinductive technology, applied in the field of medical materials, can solve the problem that the membrane does not have the function of inducing osteogenesis, and achieve the effect of maintaining mechanical properties, simple steps, and promoting the formation of new blood supply

Active Publication Date: 2022-03-08
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In view of the technical problems existing in the prior art, for example: the existing clinical commonly used membranes do not have the function of inducing osteogenesis, and the membrane materials added with osteogenic active powder in related research cannot directly produce the function of inducing osteogenesis, etc., the present invention firstly provides An osteoinductive regenerative membrane with direct osteogenic effect

Method used

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  • Osteoinductive regenerative film and its preparation method and application
  • Osteoinductive regenerative film and its preparation method and application
  • Osteoinductive regenerative film and its preparation method and application

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preparation example Construction

[0098] In order to solve the problem that the existing clinical commonly used membranes do not have the function of inducing osteogenesis or can not directly produce osteogenesis, the present invention uses degradable polymer materials and degradable osteogenic active bioglass, and adopts advanced biomaterial preparation technology - electrostatic Spinning technology to prepare osteoinductive regenerative membrane with nanofiber structure. The osteoinductive regenerative membrane is uniformly distributed with polymer fiber filaments and biological glass fiber filaments, and has a three-dimensional network structure similar to extracellular matrix. Specifically, the preparation method includes: preparing the first fiber and the second fiber by electrospinning, and interweaving the first fiber and the second fiber to form an interlaced structure.

[0099] Solvent electrospinning process

[0100] In a specific embodiment, the electrospinning includes: dissolving the polymer ma...

Embodiment 1

[0163] Electrospinning was performed using a solvent electrospinning process.

[0164] The degradable polymer polycaprolactone is dissolved in the organic solvent trifluoroethanol, and a polycaprolactone solution with a concentration of 10% is prepared. Place the polycaprolactone solution in the syringe for use. The tetraethyl orthosilicate was hydrolyzed in hydrochloric acid solution with a pH of 1.5, and the molar ratio of silicon to deionized water was 1:8. After the hydrolysis is completed, triethyl phosphate is added to continue the hydrolysis. After the hydrolysis is completed, calcium acetate and zinc acetate are added to dissolve, and finally a clear solution is obtained. After standing for 6 hours, a biological glass solution was formed, in which the molar ratio of calcium, silicon, phosphorus and zinc was 36:60:8:0.5. Place the bioglass solution in a syringe for later use.

[0165] Place the syringes containing the two components in the electrospinning machine and...

Embodiment 2

[0175] Electrospinning was performed using a solvent electrospinning process.

[0176]Dissolve the degradable polymer polylactic acid and gelatin in the organic solvent trifluoroethanol to prepare a mixed solution of polylactic acid and gelatin with a concentration of 15%, wherein the mass ratio of polylactic acid to gelatin is 1:1. Put the mixed solution of polylactic acid and gelatin in the syringe for later use. The tetraethyl orthosilicate was hydrolyzed in a nitric acid solution with a pH of 1, and the molar ratio of silicon to deionized water was 1:10. After the hydrolysis is completed, triethyl phosphate is added to continue the hydrolysis. After the hydrolysis is completed, calcium chloride and strontium acetate are added to dissolve, and finally a clear solution is obtained. After standing for 10 hours, a biological glass solution was formed, in which the molar ratio of calcium, silicon, phosphorus and zinc was 40:55:8:2. Place the bioglass solution in a syringe for...

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Abstract

The invention relates to an osteoinductive regenerative membrane, a preparation method and application thereof. The osteoinductive regenerative membrane includes first fibers and second fibers, the first fibers and the second fibers interweave to form an interlaced structure, wherein the first fibers are derived from degradable polymer materials; the The second fiber is derived from biological glass or biological glass solution; the osteoinductive regenerative membrane has a porous structure with a porosity of 30-90% and an average pore diameter of 0.1-50 μm. The osteoinductive regenerative membrane of the present invention has at least one of the following characteristics: ①After the membrane is implanted, the glass fiber filaments directly contact with the bone defect, which can directly induce osteogenesis; ②The three-dimensional network structure of nanofibers can make the nutrients Smooth penetration and the growth of new blood vessels promote the formation of new blood supply at the defect site; ③The degradation rate matches the defect repair, which can maintain long-term mechanical properties and does not require secondary surgery to remove.

Description

technical field [0001] The invention relates to an osteoinductive regeneration membrane, a preparation method and application thereof, and belongs to the field of medical materials. Background technique [0002] Guided Tissue Regeneration (GTR) is a new technology developed in the late 1980s and early 1990s. The principle is to use the physical barrier function of the membrane to isolate the lesion area from the surrounding tissue, creating a relatively closed tissue environment, so that the regenerative function of the specific tissue can be maximized. This technology was initially used in animal experiments and clinical research for the treatment of periodontal disease, and was later used to promote the repair and regeneration of bone tissue, that is, guided bone regeneration technology (Guided Bone Regeneration, GBR). Therefore, the application of guided tissue regeneration technology provides a new and effective way for the treatment of periodontal disease, the repair o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/58A61L27/50A61L27/10A61L27/18D01F1/10D01F6/62D01F8/02D01F8/14D01F9/08
CPCA61L27/56A61L27/58A61L27/50A61L27/10A61L27/18D01F6/625D01F9/08D01F8/14D01F8/02D01F1/10A61L2430/02A61L2430/12C08L67/04
Inventor 张婧邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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