A compound preparation containing troxerutin for treating thrombus and preparation method thereof
A compound preparation and a technology for troxerutin are applied to the compound preparation containing troxerutin and the field of preparation thereof, which can solve the problems of unsatisfactory absorption effect of the troxerutin preparation, and achieve enhanced controllability and medication safety. properties, improve bioavailability, prolong the effect of action time
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Embodiment 1
[0031] The present embodiment provides a troxerutin liposome and a preparation method thereof, specifically comprising the following steps:
[0032] Step 1, prepare membrane material according to the molar ratio of lecithin and cholesterol 5:2, prepare liposome raw material according to the mass ratio of troxerutin and membrane material 1:30;
[0033] Step 2: Dissolve troxerutin in purified water, dissolve the membrane material in an appropriate amount of absolute ethanol and slowly mix it with the obtained troxerutin aqueous solution, remove the solvent by rotary evaporation in a warm water bath at 30°C, and dry in vacuum overnight To obtain a lipid film, add DEPC physiological saline to dissolve and hydrate the lipid film. After hydrating on a shaker at 20°C for 2 hours, the resulting hydration system is ultrasonically treated to fully disperse the liposomes in the hydration system. A polycarbonate membrane with a pore size of 100 nm is used to process the hydration system aft...
Embodiment 2
[0035] The present embodiment provides a troxerutin magnetic liposome and a preparation method thereof, specifically comprising the following steps:
[0036] Step 1, preparation of Fe 3 o 4 Magnetic nanoparticles:
[0037] 0.5gFeCl 3 ·6H 2 O and 0.3gFeCl 2 4H 2 Dissolve O in 50 mL of deionized water, add 30 mL of 0.3 M potassium hydroxide solution, stir at 80 °C for 1 h, and place the resulting suspension on a magnet after cooling down to allow the magnetic iron oxide to settle, discard the supernatant, and collect the magnetic precipitate , washed repeatedly with distilled water and absolute ethanol to obtain Fe 3 o 4 Magnetic particles; prepare 2mg / mL PEG200 aqueous solution, according to Fe 3 o 4 The mass volume ratio of magnetic particles and PEG200 aqueous solution is 30mg: 10mL Fe 3 o 4 The magnetic particles were added to the PEG200 aqueous solution, and stirred at a speed of 800r / min for 1h under the state of ultrasonic dispersion to obtain Fe 3 o 4 magnet...
Embodiment 3
[0042] This example provides a compound preparation containing troxerutin for the treatment of thrombus and its preparation method. The compound preparation is in the form of oral liquid and includes the following components in parts by mass:
[0043] 300 parts of troxerutin liposomes prepared in Example 1, 10 parts of safflower extract, 10 parts of salvia miltiorrhiza extract, 10 parts of Chuanqiong extract, and purified water to make up to a total of 500 parts.
[0044] In this example, the safflower extract, the salvia miltiorrhiza extract, and the Chuanqiong extract are all concentrated solutions obtained by conventional water extraction.
[0045] The preparation method of the compound preparation containing troxerutin used in the treatment of thrombus in this example is as follows: mix troxerutin liposome, safflower extract, salvia miltiorrhiza extract, Chuanqiong extract and purified water, and ultrasonically disperse Evenly, a compound preparation in oral liquid dosage ...
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