Surface polymer brush modified hydrogel material as well as preparation method and application thereof

A technology of polymer brushes and hydrogels, applied in instruments, glasses/goggles, optics, etc., can solve the problems of unsatisfactory hydrophilicity and decreased mechanical properties of hydrogels, and achieve improved protein adsorption resistance, surface The effect of uniform performance and good hydrophilicity

Active Publication Date: 2021-04-09
NANJING 3H MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that the hydrogel materials prepared by zwitterionic polymers have good anti-bioadhesion function, but when the addition ratio of zwitterionic monomers such as betaines and phosphorylcholines used to prepare hydrogels is too high , it will lead to unsatisfactory hydrogel hydrophilicity and decrease in mechanical properties

Method used

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  • Surface polymer brush modified hydrogel material as well as preparation method and application thereof
  • Surface polymer brush modified hydrogel material as well as preparation method and application thereof
  • Surface polymer brush modified hydrogel material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of surface aspartic acid modified corneal contact lens, the experimental flow chart is as follows figure 1 shown.

[0035] step 1:

[0036] Put HEMA (1 mL), methacrylic acid (MAA) (8.5 μL), crosslinker ethylene glycol dimethacrylate (EGDMA) (15 μL), and photoinitiator 1299 (9.5 μL) into contact lens preparation The mold was reacted in an ultraviolet curing reactor for 30 min, and then placed in a mixed solution of ethanol and water to release the mold to obtain a contact lens.

[0037] Step 2:

[0038] Place the contact lens prepared in step 1 and 3-aminopropyltriethoxysilane in an acetone solution, stir and react at room temperature for 8 h, wash the contact lens twice with ethanol and water after the reaction is completed, and soak in 24 h in distilled water, changing the water every 8 h.

[0039] Step 3:

[0040] Using glycidyl methacrylate (GMA) as monomer (0.71 g, 5 mmol), RAFT chain transfer agent (61 mg, 0.167 mmol), AIBN (2.7 mg, 0.0167 mmol)...

Embodiment 2

[0046] Preparation of Surface Serine Modified Corneal Contact Lens

[0047] Step 1: Mix HEMA (1 mL), N-vinylpyrrolidone (NVP) (12.0 μL), crosslinker ethylene glycol dimethacrylate (EGDMA) (12 μL), and thermal initiator AIBN (20 mg) Put it into a contact lens preparation mold, react in a 70-degree constant temperature oven for 8 h, and place it in a mixed solution of ethanol and water to demould to obtain a contact lens.

[0048] Step 2, step 3 and step 4 are the same as the steps in embodiment 1.

[0049] Step 5: Add a certain amount of serine to the ethanol / water (1:4, v / v) mixed solution to prepare a 0.1 mol / L amino acid aqueous solution, and adjust the pH value to 10~12. Put the corneal contact lens prepared in step 4 into the amino acid aqueous solution, then place it in a constant temperature shaking box, and react at 50 °C for 24 h. After the reaction is finished, the corneal contact lens is taken out, and the pH value of the solution is washed to 7 with distilled wate...

Embodiment 3

[0051] Preparation of corneal contact lens modified with lactobionic acid

[0052] The experimental flow chart is as Figure 5 shown. Step 1 and step 2 are the same as those in Example 1.

[0053] Step 3: Using glycidyl methacrylate (GMA) as monomer (0.71 g, 5 mmol), add RAFT chain transfer agent (36.5 mg, 0.1 mmol), AIBN (2.7 mg, 0.0167 mmol), the oxygen in the reaction tube was removed through three cycles of liquid nitrogen freezing-vacuumizing-thawing and nitrogen gas circulation. Add 8 mL of tetrahydrofuran. It was placed in an oil bath at 70°C for 8 h, and after the reaction was completed, the atmosphere was vented and the reaction was quenched in an ice bath. The reaction solution was dropped into n-hexane for precipitation. After the polymer was purified by two dissolution-precipitation methods, it was dried to obtain polyglycidyl methacrylate (PGMA). The conversion rate of monomer is about 78%, and the degree of polymerization is 39.

[0054] Step 4: PGMA (50 m...

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Abstract

The invention discloses a preparation method of a surface polymer brush modified hydrogel material. Beta-hydroxyethyl methacrylate (HEMA) is used as a main monomer to prepare cross-linked hydrogel, and the physical and chemical properties of the hydrogel are changed by adding a third component. Then, hydroxyl on the surface of the hydrogel is activated into amino, the amino is coupled to carboxyl at the tail end of polyglycidyl methacrylate (PGMA) prepared through reversible addition-fragmentation chain transfer (RAFT) free radical polymerization, and a polymer chain is grafted to the surface of the hydrogel. Further, the surface of the hydrogel is modified with functional molecules through the reaction of small molecules with amino groups and epoxy groups in the PGMA. Through a post-modification method, the surface of the hydrogel is modified with a layer of functional polymer brush, and the length of the polymer brush can be adjusted through the RAFT polymerization reaction feeding ratio. On the basis of keeping the water content and mechanical properties of the hydrogel, the surface properties of the hydrogel are changed, and the protein adsorption resistance is improved.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to a surface polymer brush modified hydrogel material, its preparation and its application as a corneal contact lens. Background technique [0002] With the development of the times and the advancement of science and technology, in recent years, the incidence of myopia in the world has shown an overall upward trend, reaching as high as 60% to 80%. Contact lens is a medical device worn on the cornea to correct vision and treat some eye diseases. It is loved by consumers for its beauty and convenience. The materials used to prepare contact lenses mainly go through four stages, which are: hard air-impermeable material, hard air-permeable material, soft non-hydrophilic material and soft hydrophilic material. Hydrogels are three-dimensional crosslinked network polymer materials containing a large number of water molecules. The corneal contact lens made ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02G02C7/04
CPCC08G81/021G02C7/049
Inventor 王昭郝凌云张小娟宋文利梁栋
Owner NANJING 3H MEDICAL PROD CO LTD
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