Exosome drug delivery system and preparation method and application thereof

Abstract

The invention discloses an exosome drug delivery system as well as a preparation method and application thereof, provides an active drug loading system for loading a cis-platinum prodrug on an exosome by utilizing a phospholipid compound, and solves the problems of membrane rupture, low drug loading capacity and the like caused by an exosome drug loading strategy. According to the invention, the cis-platinum prodrug is prepared in advance and is prepared into the liposome, and then the liposome is mixed with the exosome to realize active drug loading, so that the fusion effect of the phospholipid compound and the exosome membrane is utilized, the completeness of the exosome membrane is protected, and the drug loading capacity of the exosome to the anti-cancer drug is improved.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to an exosome drug delivery system and its preparation method and application. Background technique

[0002] Exosomes are small vesicles with a diameter of 30-150nm in a saucer-shaped structure, which contain RNA, protein, microRNA, DNA fragments and other components. All eukaryotic cells and some prokaryotic cells can secrete it, and it is mainly distributed in various body fluids such as blood, saliva, urine, amniotic fluid and breast milk. It is the early endosome formed by the invagination of the plasma membrane of the cell, and the encapsulation material of the endosome forms a multivesicular body, and then the multivesicular body is released after fusion with the plasma membrane. It is the structure (phospholipid bilayer and vesicle-like structure) and physiological properties of exosomes that make them biocompatible. And exosomes can freely cross the blood-brai...

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